Gene- and tissue-specificity of mutation in Big Blue® rats treated with the hepatocarcinogenN-hydroxy-2-acetylaminofluorene†

Spectra of spontaneous and mutagen-induced mutations in the lacI gene in transgenic mice.

1991 • 473 citations

Sequence of the lacI gene

1978 • 463 citations

Statistical test for the comparison of samples from mutational spectra

1987 • 292 citations

The ‘A rule’ of mutagen specificity: A consequence of DNA polymerase bypass of non‐instructional lesions?

1991 • 260 citations

Activating mutations of the c-Ha-ras protooncogene in chemically induced hepatomas of the male B6C3 F1 mouse.

1986 • 250 citations

Genetic toxicity of 2-acetylaminofluorene, 2-aminofluorene and some of their metabolites and model metabolites

1994 • 228 citations

Computer program for the analysis of mutational spectra: application to p53 mutations

1994 • 216 citations

Analysis of spontaneous and induced mutations in transgenic mice using a lambda ZAP/lacl shuttle vector

1991 • 197 citations

The use of shuttle vectors for mutation analysis in transgenic mice and rats

1994 • 188 citations

Carcinogen-induced mutation spectrum in wild-type, uvrA and umuC strains of Escherichia coli

1984 • 183 citations

Transgenic systems for in vivo mutation analysis

1993 • 174 citations

Carcinogens leave fingerprints

1992 • 169 citations

Hot spots of frameshift mutations induced by the ultimate carcinogen N- acetoxy-N-2-acetylaminofluorene

1981 • 164 citations

DNA binding and mutation spectra of the carcinogen N-2-aminofluorene in Escherichia coli

1985 • 146 citations

p53 tumor suppressor gene: at the crossroads of molecular carcinogenesis, molecular epidemiology, and cancer risk assessment.

1996 • 130 citations

NMR and computational characterization of the N-(deoxyguanosin-8-yl)aminofluorene adduct [(AF)G] opposite adenosine in DNA: (AF)G[syn].cntdot.A[anti] pair formation and its pH dependence

1989 • 118 citations

Spontaneous and X-ray-induced deletion mutations in a LacZ plasmid-based transgenic mouse model

1995 • 85 citations

Tamoxifen causes gene mutations in the livers of lambda/lacI transgenic rats.

1997 • 70 citations

Species-specific differences in hepatic mutant frequency and mutational spectrum among lambda/lacl transgenic rats and mice following exposure to aflatoxin B₁

1996 • 59 citations

Mutations induced by aromatic amine DNA adducts in pBR322

1994 • 55 citations

The gene encoding hypoxanthine-guanine phosphoribosyltransferase as target for mutational analysis: PCR cloning and sequencing of the cDNA from the rat

1992 • 53 citations

Comparison of in vivo mutagenesis in the endogenous Hprt gene and the lacI transgene of Big Blue® rats treated with 7,12-dimethylbenz[a]anthracene

1998 • 47 citations

Activation of the Ha-, Ki-, and N-ras genes in chemically induced liver tumors from CD-1 mice.

1992 • 47 citations

Targeted mutations induced by a single acetylaminofluorene DNA adduct in mammalian cells and bacteria.

1988 • 43 citations

Excision of the imidazole ring-opened form of N-2-aminofluorene-C(8)-guanine adduct in poly(dG-dC) by Escherichia coli fonnamidopyrimidine-DNA glycosylase

1989 • 42 citations

DNA base changes and RNA levels in N-acetoxy-2-acetylaminofluorene-induced dihydrofolate reductase mutants of Chinese hamster ovary cells

1989 • 41 citations

Comparison of the types of mutations induced by 7,12-dimethylbenz[a]anthracene in thelacI andhprt genes of Big Blue® rats

1998 • 35 citations

Rapid release of carcinogen-guanine adducts from DNA after reaction with N-acetoxy-2-acetylaminofluorene or N-benzoyloxy-N-methyl-4-aminoazobenzene

1982 • 35 citations

Molecular analysis of lacI mutations in Rat2™ cells exposed to 7,12-dimethylbenz[a]anthracene: evidence for DNA sequence and DNA strand biases for mutation

1996 • 32 citations

Comparison of mutant frequencies and types of mutations induced by thiotepa in the endogenous Hprt gene and transgenic lacI gene of Big Blue® rats

1998 • 29 citations

Hprt mutant frequency and molecular analysis of Hprt mutations in Fischer 344 rats treated with thiotepa

1999 • 24 citations

p53 Tumor Suppressor Gene: At the Crossroads of Molecular Carcinogenesis, Molecular Epidemiology, and Cancer Risk Assessment

1996 • 24 citations

Induction of mutations by 2-acetylaminofluorene in lad transgenic B6C3F1 mouse liver

1998 • 23 citations

Mutagenesis originating in site-specific DNA damage

1986 • 17 citations

A mutational hot spot induced by N-hydroxy-aminofluorene in dihydrofolate reductase mutants of Chinese hamster ovary cells

1993 • 16 citations

Comparison of hprt and lacI mutant frequency with DNA adduct formation in N‐hydroxy‐2‐acetylaminofluorene–treated Big Blue® rats†

2001 • 15 citations

Expansion of rat 6-thioguanine-resistant T-lymphocyte clones by stimulation with ionomycin and a phorbol ester

1998 • 13 citations

DNA sequence analysis of mutations induced by N-2-acetylamino-7-iodofluorene in plasmid pBR322 in Escherichia coli

1990 • 10 citations

Influence of nucleotide excision repair on N-hydroxy-2-acetylaminofluorene-induced mutagenesis studied in λlacZ-transgenic mice

1998 • 6 citations

Sequence specificity of Hprt lymphocyte mutation in rats fed the hepatocarcinogen 2-acetylaminofluorene

1999 • 6 citations