Frequent mutations of the rat ?-catenin gene in colon cancers induced by methylazoxymethanol acetate plus 1-hydroxyanthraquinone

Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC

1997 • 3,847 citations

Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC ^−/− Colon Carcinoma

1997 • 3,234 citations

A general method for isolation of high molecular weight DNA from eukaryotes

1976 • 2,827 citations

Binding of GSK3β to the APC-β-Catenin Complex and Regulation of Complex Assembly

1996 • 1,382 citations

Association of the APC Gene Product with β-Catenin

1993 • 1,215 citations

Stabilization of β-Catenin by Genetic Defects in Melanoma Cell Lines

1997 • 1,215 citations

E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton.

1994 • 647 citations

β-Catenin mutations in cell lines established from human colorectal cancers

1997 • 483 citations

Beta-catenin is frequently mutated and demonstrates altered cellular location in azoxymethane-induced rat colon tumors.

1998 • 204 citations

Specific 5'-GGGA-3'-->5'-GGA-3' mutation of the Apc gene in rat colon tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.

1995 • 148 citations

High frequency of beta-catenin (ctnnb1) mutations in the colon tumors induced by two heterocyclic amines in the F344 rat.

1998 • 129 citations

Dominant negative inhibition of the association between beta-catenin and c-erbB-2 by N-terminally deleted beta-catenin suppresses the invasion and metastasis of cancer cells.

1996 • 110 citations

Genomic Organization of the Human β-Catenin Gene (CTNNB1)

1996 • 93 citations

Carcinogenicity of naturally occurring 1-hydroxyanthraquinone in rats: induction of large bowel, liver and stomach neoplasms

1990 • 86 citations

Cell kinetic analysis of the mucosal epithelium and assay of ornithine decarboxylase activity during the process of 1-hydroxyanthraquinone-induced large bowel carcinogenesis in rats

1992 • 25 citations

No involvement of Ki‐ras or p53 gene mutations in colitis‐associated rat colon tumors induced by 1‐hydroxyanthraquinone and methylazoxymethanol acetate

1995 • 23 citations

No involvement ofAPC gene mutations in ulcerative colitis–associated rat colon carcinogenesis induced by 1-hydroxyanthraquinone and methylazoxymethanol acetate

1997 • 18 citations

The synergistic effect of 1-hydroxyanthraquinone on methylazoxymethanol acetate-induced carcinogenesis in rats

1991 • 18 citations

Characterization of the human β-catenin gene

1996 • 2 citations