Activating mutations in human <scp>C</scp>‐Ha‐ras‐1 protooncogene induced by stereoisomeric fjord‐region benzo[c]chrysene diol‐epoxides

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1982 • 776 citations

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1985 • 733 citations

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1982 • 706 citations

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1984 • 290 citations

DNA adducts from carcinogenic and noncarcinogenic enantiomers of benzo[a]pyrenedihydrodiol epoxide

1989 • 281 citations

Binding of Nenzo[ a ]pyrene 7,8-Diol-9,10-Epoxides to DNA, RNA, and Protein of Mouse Skin Occurs with High Stereoselectivity

1978 • 271 citations

ras gene Amplification and malignant transformation.

1985 • 204 citations

Activation of c-Ha-ras-1 proto-oncogene by in vitro modification with a chemical carcinogen, benzo(a)pyrene diol-epoxide

1984 • 154 citations

Mutations activating human c-Ha-ras1 protooncogene (HRAS1) induced by chemical carcinogens and depurination.

1986 • 131 citations

Covalent nucleoside adducts of benzo[a]pyrene 7,8-diol 9,10-epoxides: structural reinvestigation and characterization of a novel adenosine adduct on the ribose moiety

1991 • 130 citations

Optically active benzo[c]phenanthrene diol epoxides bind extensively to adenine in DNA

1987 • 116 citations

Specific activation of the cellular Harvey-ras oncogene in dimethylbenzanthracene-induced mouse mammary tumors.

1986 • 116 citations

Chemical characterization of DNA adducts derived from the configurationally isomeric benzo[c]phenanthrene-3,4-diol 1,2-epoxides

1987 • 88 citations

Synthesis and mutagenicity of the diastereomeric fjord-region 11,12-dihydrodiol 13,14-epoxides of dibenzo [a,l]pyrene

1994 • 84 citations

Fjord- and bay-region diol-epoxides investigated for stability, SOS induction in Escherichia coli, and mutagenicity in Salmonella typhimurium and mammalian cells.

1991 • 83 citations

Induction of activating mutations in the human c‐Ha‐ras‐1 proto‐oncogene by oxygen free radicals

1994 • 78 citations

Tumorigenicity of optical isomers of the diastereomeric bay-region 3,4-diol-1,2-epoxides of benzo(c)phenanthrene in murine tumor models.

1986 • 76 citations

Mutagenicity of the enantiomers of the diastereomeric bay-region benzo(c)phenanthrene 3,4-diol-1,2-epoxides in bacterial and mammalian cells.

1984 • 52 citations

Reaction with DNA and Mutagenic Specificity of syn-Benzo[g]chrysene 11,12-Dihydrodiol 13,14-Epoxide

1994 • 43 citations

Relationship between mutagenicity and DNA adduct formation in mammalian cells for fjord- and bay-region diol-epoxides of polycyclic aromatic hydrocarbons

1991 • 40 citations

Characterization of benzo[a]pyrene-initiated mouse skin papillomas for Ha-ras mutations and protein kinase C levels

1993 • 40 citations

Mutagenic specificities of four stereoisomeric benzo[c]phenanthrene dihydrodiol epoxides.

1992 • 39 citations

Stereochemical specificity in the metabolic activation of benzo(c)phenanthrene to metabolites that covalently bind to DNA in rodent embryo cell cultures.

1987 • 33 citations

Formation and persistence of DNA, RNA, and protein adducts in mouse skin exposed to pure optical enantiomers of 7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10-tetrahydrobenzo(a)pyre ne in vivo.

1984 • 29 citations

Contrasting incidence of ras mutations in rat mammary and mouse skin tumors induced by anti-benzo[c]phenanthrene-3,4-diol-1,2-epoxide

1994 • 27 citations

Mutagenic potential of DNA adducts formed by diol-epoxides, triol-epoxides and the K-region epoxide of chrysene in mammalian cells

1986 • 22 citations

Analysis of point mutations in murine c‐Ha‐ras of skin tumors initiated with dibenz[a,j]anthracene and derivatives

1992 • 19 citations

Transformation of NIH3T3 cells by transfection with UV-irradiated human c-Ha-ras-1 proto-oncogene DNA.

1991 • 18 citations

Dimethylchrysenediol epoxides: mutagenicity in Salmonella typhimurium, tumorigenicity in newborn mice, and reactivity with deoxyadenosine in DNA

1992 • 17 citations

Sequence specificity in the interaction of the four stereoisomeric benzo[c]phenanthrene dihydrodiol epoxides with the supF gene.

1993 • 13 citations

Chloride ions catalyze the formation of cis adducts inthe binding of anti-benzo[a]pyrene diol epoxide to nucleicacids.

1994 • 11 citations

Activating mutations in human c-Ha-ras-1 gene induced by reactive derivatives of safrole and the glutamic pyrolysis product, Glu-P-3

1988 • 10 citations

Transformation of NIH3T3 cells by transfection with UV-irradiated human c-Ha-ras-1 proto-oncogene DNA.

1991 • 9 citations

Effect of DNA Base Sequence on the Configuration of Deoxyadenosine Adducts Formed by the Fjord Region Diol Epoxide, (+)-(1R,2S,3R,4S)-3,4-Dihydroxy-1,2-epoxy-1,2,3,4-tetrahydrobenzo[c]phenanthrene

1994 • 4 citations