Mtd, a Novel Bcl-2 Family Member Activates Apoptosis in the Absence of Heterodimerization with Bcl-2 and Bcl-XL

A simple method for displaying the hydropathic character of a protein

1982 • 22,471 citations

Apoptosis in the Pathogenesis and Treatment of Disease

1995 • 6,610 citations

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

1993 • 6,009 citations

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

1988 • 3,194 citations

Bad, a heterodimeric partner for Bcl-xL and Bcl-2, displaces bax and promotes cell death

1995 • 2,114 citations

Double identity for proteins of the Bcl-2 family

1997 • 1,511 citations

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

1996 • 1,456 citations

Structure of Bcl-x _L -Bak Peptide Complex: Recognition Between Regulators of Apoptosis

1997 • 1,429 citations

Life, death, and the pursuit of apoptosis.

1996 • 1,333 citations

BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax

1994 • 1,303 citations

bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship

1991 • 1,090 citations

Inhibition of Bax Channel-Forming Activity by Bcl-2

1997 • 1,023 citations

Deregulated Bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cell lines.

1990 • 926 citations

BID: a novel BH3 domain-only death agonist.

1996 • 921 citations

BAX-induced cell death may not require interleukin 1β-converting enzyme-like proteases

1996 • 911 citations

Multiple Bcl-2 family members demonstrate selective dimerizations with Bax.

1995 • 832 citations

Bcl-xL forms an ion channel in synthetic lipid membranes

1997 • 817 citations

Daxx, a Novel Fas-Binding Protein That Activates JNK and Apoptosis

1997 • 797 citations

Induction of apoptosis by the Bcl-2 homologue Bak

1995 • 738 citations

A rapid and simple method for the isolation of apoptotic DNA fragments

1994 • 660 citations

Interaction of CED-4 with CED-3 and CED-9: A Molecular Framework for Cell Death

1997 • 635 citations

Channel formation by antiapoptotic protein Bcl-2

1997 • 604 citations

Cloning of a bcl-2 homologue by interaction with adenovirus E1B 19K

1995 • 501 citations

A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions.

1995 • 491 citations

Bax-independent inhibition of apoptosis by Bcl-XL

1996 • 484 citations

Proapoptotic Protein Bax Heterodimerizes with Bcl-2 and Homodimerizes with Bax via a Novel Domain (BH3) Distinct from BH1 and BH2

1996 • 462 citations

bcl-xLx is the major bcl-x mRNA form expressed during murine development and its product localizes to mitochondria

1994 • 435 citations

Bik, a novel death-inducing protein shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and cellular survival-promoting proteins.

1995 • 431 citations

harakiri, a novel regulator of cell death, encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-XL

1997 • 381 citations

Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members

1997 • 357 citations

The E1B 19K protein blocks apoptosis by interacting with and inhibiting the p53-inducible and death-promoting Bax protein.

1996 • 346 citations

Interaction and Regulation of Subcellular Localization of CED-4 by CED-9

1997 • 345 citations

CLARP, a death effector domain-containing protein interacts with caspase-8 and regulates apoptosis

1997 • 316 citations

bcl-x is expressed in embryonic and postnatal neural tissues and functions to prevent neuronal cell death.

1995 • 289 citations

Induction of Apoptosis by Human Nbk/Bik, a BH3-Containing Protein That Interacts with E1B 19K

1996 • 201 citations

Bcl-2 protein expression during murine development.

1994 • 164 citations

Interaction and Regulation of the Caenorhabditis elegans Death Protease CED-3 by CED-4 and CED-9

1997 • 130 citations

Crystal Structure of Rat Bcl-xL

1997 • 121 citations

Bax Can Antagonize Bcl-XL during Etoposide and Cisplatin-induced Cell Death Independently of Its Heterodimerization with Bcl-XL

1996 • 101 citations

Bak can accelerate chemotherapy-induced cell death independently of its heterodimerization with Bcl-XL and Bcl-2

1997 • 50 citations

A1 demonstrates restricted tissue distribution during embryonic development and functions to protect against cell death.

1996 • 39 citations