Redistribution of Bax from Cytosol to Membranes Is Induced by Apoptotic Stimuli and Is an Early Step in the Apoptotic Pathway

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

1993 • 6,009 citations

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

1995 • 4,003 citations

Movement of Bax from the Cytosol to Mitochondria during Apoptosis

1997 • 1,805 citations

Genetic control of programmed cell death in the nematode C. elegans

1986 • 1,790 citations

Double identity for proteins of the Bcl-2 family

1997 • 1,511 citations

Cytosol-to-membrane redistribution of Bax and Bcl-X_Lduring apoptosis

1997 • 1,117 citations

Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis

1996 • 980 citations

Caenorhabditis elegans gene ced-9 protects cells from programmed cell death

1992 • 889 citations

BAX Is Required for Neuronal Death after Trophic Factor Deprivation and during Development

1996 • 745 citations

A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions.

1995 • 491 citations

Low molecular weight heparins: prophylaxis of venous thromboembolism in surgical patients.

1997 • 399 citations

The Mitochondrial F0F1-ATPase Proton Pump Is Required for Function of the Proapoptotic Protein Bax in Yeast and Mammalian Cells

1998 • 273 citations

Constitutive production of a unique lymphokine (IL 3) by the WEHI-3 cell line.

1982 • 227 citations

Advances in apoptosis research

1997 • 194 citations

An ICE‐like protease is a common mediator of apoptosis induced by diverse stimuli in human monocytic THP.1 cells

1995 • 158 citations

CED-4—The Third Horseman of Apoptosis

1997 • 116 citations

Induction of the death-promoting genebax-? sensitizes cultured breast-cancer cells to drug-induced apoptosis

1996 • 109 citations

The BH3 Domain of Bax is Sufficient for Interaction of Bax with itself and with other Family Members and it is Required for Induction of Apoptosis

1997 • 56 citations

Programmed Cell Death and AIDS Pathogenesis: Significance and Potential Mechanisms

1995 • 42 citations

Bcl-xLOverexpression Restricts Heat-Induced Apoptosis and Influences hsp70, bcl-2, and Bax Protein Levels in FL5.12 Cells

1997 • 29 citations

Altered Sensitivity to Retinoid-Induced Apoptosis Associated with Changes in the Subcellular Distribution of Bcl-2

1997 • 27 citations