The Bcl‐2 family pro‐apoptotic molecule, BNIP3 regulates activation‐induced cell death of effector cytotoxic T lymphocytes

BCL-2 family members and the mitochondria in apoptosis

1999 • 3,657 citations

Bax-Deficient Mice with Lymphoid Hyperplasia and Male Germ Cell Death

1995 • 1,500 citations

Proapoptotic Bcl-2 Relative Bim Required for Certain Apoptotic Responses, Leukocyte Homeostasis, and to Preclude Autoimmunity

1999 • 1,500 citations

Induction of apoptosis in mature T cells by tumour necrosis factor

1995 • 1,139 citations

Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen

1989 • 1,010 citations

Homeostasis and Self-Tolerance in the Immune System: Turning Lymphocytes off

1998 • 989 citations

Fas and Fas ligand: lpr and gld mutations

1995 • 906 citations

Checkpoints of dueling dimers foil death wishes

1994 • 806 citations

Inhibition of Th1 Development Mediated by GATA-3 through an IL-4-Independent Mechanism

1998 • 800 citations

BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes

2002 • 772 citations

Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia

2000 • 754 citations

The fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice

1994 • 708 citations

HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors.

2001 • 688 citations

BNIP3 and Genetic Control of Necrosis-Like Cell Death through the Mitochondrial Permeability Transition Pore

2000 • 605 citations

Activated T Cell Death In Vivo Mediated by Proapoptotic Bcl-2 Family Member Bim

2002 • 564 citations

Reactive Oxygen Species Regulate Activation-Induced T Cell Apoptosis

1999 • 485 citations

Effector differentiation is not prerequisite for generation of memory cytotoxic T lymphocytes

2001 • 407 citations

BNIP3 Heterodimerizes with Bcl-2/Bcl-XL and Induces Cell Death Independent of a Bcl-2 Homology 3 (BH3) Domain at Both Mitochondrial and Nonmitochondrial Sites

2000 • 337 citations

The Roles of Fas/APO-1 (CD95) and TNF in Antigen-Induced Programmed Cell Death in T Cell Receptor Transgenic Mice

1996 • 325 citations

The E1B 19K/Bcl-2–binding Protein Nip3 is a Dimeric Mitochondrial Protein that Activates Apoptosis

1997 • 319 citations

Hypoxia induces the expression of the pro-apoptotic gene BNIP3

2001 • 314 citations

Role of antigen, CD8, and cytotoxic T lymphocyte (CTL) avidity in high dose antigen induction of apoptosis of effector CTL.

1996 • 222 citations

Adenovirus E1B-19K/BCL-2 Interacting Protein BNIP3 Contains a BH3 Domain and a Mitochondrial Targeting Sequence

1998 • 211 citations

Bax alpha perturbs T cell development and affects cell cycle entry of T cells.

1996 • 170 citations

Visualization and quantification of T cell–mediated cytotoxicity using cell-permeable fluorogenic caspase substrates

2002 • 160 citations

Studies of T cell deletion and T cell anergy following in vivo administration of SEB to normal and lupus-prone mice.

1993 • 125 citations

Tumor necrosis factor receptor p55 mediates deletion of peripheral cytotoxic T lymphocytes in vivo

1996 • 124 citations

TNF receptor 1 (TNFR1) and CD95 are not required for T cell deletion after virus infection but contribute to peptide-induced deletion under limited conditions

2000 • 75 citations

Homeostatic regulation of CD8⁺ T cells after antigen challenge in the absence of Fas (CD95)

1996 • 70 citations

Immune down-regulation and peripheral deletion of CD8 T cells does not require TNF receptor-ligand interactions nor CD95 (Fas, APO-1)

2000 • 70 citations

A Zinc-finger Protein, PLAGL2, Induces the Expression of a Proapoptotic Protein Nip3, Leading to Cellular Apoptosis

2002 • 68 citations

Different susceptibility of cytotoxic T cells to CD95 (Fas/Apo-1) ligand-mediated cell death after activation in vitro versus in vivo.

1996 • 67 citations

TCR ligation on CD8+ T cells creates double-negative cells in vivo.

1998 • 66 citations

T-lymphocyte downregulation after acute viral infection is not dependent on CD95 (Fas) receptor-ligand interactions

1996 • 66 citations

TCR Ligation on CD8+ T Cells Creates Double-Negative Cells In Vivo

1998 • 64 citations

Leukotriene B₄ promotes reactive oxidant generation and leukocyte adherence during acute hypoxia

2001 • 53 citations

Insights from transgenic mice regarding the role ofbcl-2 in normal and neoplastic lymphoid cells

1994 • 33 citations