Regulation of p53 localization

p53 Mutations in Human Cancers

1991 • 8,133 citations

Mdm2 promotes the rapid degradation of p53

1997 • 4,336 citations

Regulation of p53 stability by Mdm2

1997 • 3,238 citations

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1992 • 3,110 citations

A short amino acid sequence able to specify nuclear location

1984 • 2,529 citations

DNA Damage-Induced Phosphorylation of p53 Alleviates Inhibition by MDM2

1997 • 2,089 citations

CRM1 Is an Export Receptor for Leucine-Rich Nuclear Export Signals

1997 • 2,062 citations

Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53

1998 • 2,034 citations

Enhanced Phosphorylation of p53 by ATM in Response to DNA Damage

1998 • 1,734 citations

Two interdependent basic domains in nucleoplasmin nuclear targeting sequence: Identification of a class of bipartite nuclear targeting sequence

1991 • 1,501 citations

The p53 pathway

1999 • 1,322 citations

Identification of a signal for rapid export of proteins from the nucleus

1995 • 1,186 citations

Exportin 1 (Crm1p) Is an Essential Nuclear Export Factor

1997 • 1,144 citations

The HIV-1 Rev Activation Domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs

1995 • 1,127 citations

Nucleocytoplasmic Transport

1996 • 1,071 citations

A role for ATR in the DNA damage-induced phosphorylation of p53

1999 • 1,043 citations

Nucleocytoplasmic transport: signals, mechanisms and regulation

1997 • 987 citations

p53 and Human Cancer: The First Ten Thousand Mutations

1999 • 968 citations

Leptomycin B Inhibition of Signal-Mediated Nuclear Export by Direct Binding to CRM1

1998 • 801 citations

A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking

1999 • 727 citations

Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein

1998 • 610 citations

Two distinct mechanisms alter p53 in breast cancer: mutation and nuclear exclusion.

1992 • 587 citations

Wild-type p53 protein undergoes cytoplasmic sequestration in undifferentiated neuroblastomas but not in differentiated tumors.

1995 • 421 citations

Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53

1999 • 366 citations

Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2

1999 • 362 citations

Nuclear and nucleolar targeting sequences of c-erb-A, c-myb, N-myc, p53, HSP70, and HIV tat proteins

1989 • 358 citations

Human p53 is phosphorylated by p60-cdc2 and cyclin B-cdc2.

1990 • 353 citations

Increased and altered DNA binding of human p53 by S and G2/M but not Gl cyclin-dependent kinases

1995 • 334 citations

Nuclear Accumulation of p53 Protein Is Mediated by Several Nuclear Localization Signals and Plays a Role in Tumorigenesis

1990 • 328 citations

Control of Cyclin B1 localization through regulated binding of the nuclear export factor CRM1

1998 • 316 citations

Identification of the Human c-myc Protein Nuclear Translocation Signal

1988 • 299 citations

DNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerization

1999 • 296 citations

Damage-mediated Phosphorylation of Human p53 Threonine 18 through a Cascade Mediated by a Casein 1-like Kinase

2000 • 285 citations

Cytoplasmic Sequestration of Wild-Type p53 Protein Impairs the G₁ Checkpoint after DNA Damage

1996 • 274 citations

Leptomycin B-sensitive nuclear export of MAPKAP kinase 2is regulated by phosphorylation

1998 • 270 citations

Phosphorylation of Serine 392 Stabilizes the Tetramer Formation of Tumor Suppressor Protein p53

1997 • 249 citations

Importins and exportins: how to get in and out of the nucleus

1998 • 242 citations

p53 transformation-related protein: Detection by monoclonal antibody in mouse and human cells

1981 • 222 citations

Inactivation of Tumor Suppressor p53 by Mot-2, a hsp70 Family Member

1998 • 222 citations

Molecular Cloning and Cell Cycle-dependent Expression of Mammalian CRM1, a Protein Involved in Nuclear Export of Proteins

1997 • 212 citations

c-myc and bcl-2 modulate p53 function by altering p53 subcellular trafficking during the cell cycle.

1994 • 210 citations

Nuclear accumulation of p53 protein is mediated by several nuclear localization signals and plays a role in tumorigenesis.

1990 • 207 citations

Identification of the human c-myc protein nuclear translocation signal.

1988 • 207 citations

p34cdc2-mediated phosphorylation at T124 inhibits nuclear import of SV-40 T antigen proteins.

1991 • 203 citations

Amino acid sequences that determine the nuclear localization of yeast histone 2B.

1987 • 194 citations

Protein synthesis required to anchor a mutant p53 protein which is temperature-sensitive for nuclear transport

1991 • 180 citations

Nuclear transport kinetics depend on phosphorylation-site-containing sequences flanking the karyophilic signal of the Simian virus 40 T-antigen.

1989 • 175 citations

Subcellular distribution of the p53 protein during the cell cycle of Balb/c 3T3 cells.

1990 • 170 citations

p53 gene mutations, p53 protein accumulation and compartmentalization in colorectal adenocarcinoma.

1995 • 162 citations

Covalent and noncovalent modifiers of the p53 protein

1999 • 133 citations

A Bipartite Nuclear Localization Signal Is Required for p53 Nuclear Import Regulated by a Carboxyl-terminal Domain

1999 • 127 citations

A bipartite nuclear localization signal in the retinoblastoma gene product and its importance for biological activity.

1993 • 98 citations

P53 transformation-related protein accumulates in the nucleus of transformed fibroblasts in association with the chromatin and is found in the cytoplasm of non-transformed fibroblasts.

1983 • 93 citations

Nuclear exclusion of p53 in a subset of tumors requires MDM2 function

2000 • 93 citations

The tumor suppressor p53 is subject to both nuclear import and export, and both are fast, energy-dependent and lectin-inhibited

1997 • 91 citations

c-Myc and Bcl-2 modulate p53 function by altering p53 subcellular trafficking during the cell cycle

1994 • 90 citations

Bcl-2 inhibits p53 nuclear import following DNA damage

1997 • 86 citations

Protein phosphorylation sites regulate the function of the bipartite NLS of nucleolin.

1997 • 69 citations

Concerted Regulation of Wild-Type p53 Nuclear Accumulation and Activation by S100B and Calcium-Dependent Protein Kinase C

1999 • 64 citations

Association of insulin‐like growth‐factor‐I‐induced DNA synthesis with phosphorylation and nuclear exclusion of p53 in human breast cancer MCF‐7 cells

1993 • 62 citations

The nuclear import of p53 is determined by the presence of a basic domain and its relative position to the nuclear localization signal

1999 • 56 citations

Regulation of p53 protein function through alterations in protein-folding pathways

1999 • 55 citations

Awakening angels

1998 • 54 citations

Cooperation of a Single Lysine Mutation and a C-terminal Domain in the Cytoplasmic Sequestration of the p53 Protein

1998 • 51 citations

Abrogation of wild-type p53 mediated growth-inhibition by nuclear exclusion.

1996 • 47 citations

A functional bipartite nuclear localisation signal in the cytokine interleukin‐5

1997 • 41 citations