Nitric oxide, a biological effector

Free radicals in biology and medicine

1991 • 17,840 citations

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

1980 • 12,033 citations

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

1990 • 7,068 citations

Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.

1987 • 5,027 citations

Vascular endothelial cells synthesize nitric oxide from L-arginine

1988 • 4,800 citations

Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.

1990 • 3,304 citations

Localization of nitric oxide synthase indicating a neural role for nitric oxide

1990 • 2,996 citations

Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production.

1988 • 2,865 citations

Nitric oxide: A cytotoxic activated macrophage effector molecule

1988 • 2,050 citations

Biology of microorganisms

1970 • 1,982 citations

Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells.

1989 • 1,747 citations

Macrophage oxidation of L-arginine to nitrite and nitrate: nitric oxide is an intermediate

1988 • 1,622 citations

Macrophage Cytotoxicity: Role for L-Arginine Deiminase and Imino Nitrogen Oxidation to Nitrite

1987 • 1,533 citations

Formation of nitric oxide from L-arginine in the central nervous system: a transduction mechanism for stimulation of the soluble guanylate cyclase.

1989 • 1,443 citations

Nitric oxide activates guanylate cyclase and increases guanosine 3′:5′-cyclic monophosphate levels in various tissue preparations

1977 • 1,422 citations

L-arginine is the physiological precursor for the formation of nitric oxide in endothelium-dependent relaxation

1988 • 1,379 citations

Biosynthesis of nitric oxide from l-arginine

1989 • 1,220 citations

An L-arginine/nitric oxide pathway present in human platelets regulates aggregation.

1990 • 1,209 citations

Mammalian nitrate biosynthesis: mouse macrophages produce nitrite and nitrate in response to Escherichia coli lipopolysaccharide.

1985 • 1,146 citations

Nitric oxide as an inhibitory non-adrenergic non-cholinergic neurotransmitter

1990 • 1,012 citations

L-arginine is required for expression of the activated macrophage effector mechanism causing selective metabolic inhibition in target cells.

1987 • 958 citations

The Biology of Nitrogen Fixation

1976 • 875 citations

Macrophage killing of Leishmania parasite in vivo is mediated by nitric oxide from L-arginine.

1990 • 751 citations

Activated macrophages destroy intracellular Leishmania major amastigotes by an L-arginine-dependent killing mechanism.

1990 • 690 citations

Endothelium-derived relaxing factor

1988 • 686 citations

Macrophage Oxidation of L-Arginine to Nitric Oxide, Nitrite, and Nitrate

1989 • 681 citations

Macrophage synthesis of nitrite, nitrate, and N-nitrosamines: precursors and role of the respiratory burst.

1987 • 678 citations

Nitrate biosynthesis in man.

1981 • 677 citations

The Assimilatory Nitrate-Reducing System and its Regulation

1981 • 656 citations

The NO hypothesis: possible effects of a short-lived, rapidly diffusible signal in the development and function of the nervous system.

1990 • 653 citations

Differentiation of murine macrophages to express nonspecific cytotoxicity for tumor cells results in L-arginine-dependent inhibition of mitochondrial iron-sulfur enzymes in the macrophage effector cells.

1988 • 592 citations

Microbiostatic effect of murine-activated macrophages for Toxoplasma gondii. Role for synthesis of inorganic nitrogen oxides from L-arginine.

1990 • 573 citations

Reduced Biopterin as a Cofactor in the Generation of Nitrogen Oxides by Murine Macrophages

1989 • 571 citations

Reversal of endotoxin-mediated shock by NG-methyl-L-arginine, an inhibitor of nitric oxide synthesis

1990 • 562 citations

Reaction of superoxide with nitric oxide to form peroxonitrite in alkaline aqueous solution

1985 • 512 citations

EPR demonstration of iron-nitrosyl complex formation by cytotoxic activated macrophages.

1990 • 512 citations

Interferon‐γ and tumor necrosis factor induce the L‐arginine‐dependent cytotoxic effector mechanism in murine macrophages^*

1988 • 511 citations

Activated murine macrophages secrete a metabolite of arginine with the bioactivity of endothelium-derived relaxing factor and the chemical reactivity of nitric oxide.

1989 • 464 citations

Murine cytotoxic activated macrophages inhibit aconitase in tumor cells. Inhibition involves the iron-sulfur prosthetic group and is reversible.

1986 • 421 citations

Nitric oxide: biosynthesis and biological significance

1989 • 421 citations

Hepatocytes produce nitrogen oxides from L-arginine in response to inflammatory products of Kupffer cells.

1989 • 405 citations

Anti-inflammatory glucocorticoids inhibit the induction by endotoxin of nitric oxide synthase in the lung, liver and aorta of the rat

1990 • 389 citations

Role of nitric oxide in maintaining vascular integrity in endotoxin‐induced acute intestinal damage in the rat

1990 • 369 citations

Metabolic fate of L-arginine in relation to microbiostatic capability of murine macrophages.

1990 • 356 citations

Electromagnetic Properties of Hemoproteins

1972 • 344 citations

Specific amino acid (L-arginine) requirement for the microbiostatic activity of murine macrophages.

1988 • 337 citations

Restoration of the responsiveness of purified guanylate cyclase to nitrosoguanidine, nitric oxide, and related activators by heme and hemeproteins. Evidence for involvement of the paramagnetic nitrosyl-heme complex in enzyme activation.

1978 • 327 citations

An L-arginine-dependent mechanism mediates kupffer cell inhibition of hepatocyte protein synthesis in vitro

1989 • 325 citations

Reactions of nitric oxide coordinated to transition metals

1979 • 299 citations

Alterations of ribonucleotide reductase activity following induction of the nitrite-generating pathway in adenocarcinoma cells.

1990 • 284 citations

Activation of soluble guanylate cyclase by NO-hemoproteins involves NO-heme exchange. Comparison of heme-containing and heme-deficient enzyme forms.

1986 • 272 citations

An infrared study of nitric oxide bonding to heme B and hemoglobin A. Evidence for inositol hexaphosphate induced cleavage of proximal histidine to iron bonds

1976 • 272 citations

Endothelium-derived relaxing factor reduces platelet adhesion to bovine endothelial cells.

1988 • 263 citations

Nitrite Inhibition of Clostridium botulinum : Electron Spin Resonance Detection of Iron-Nitric Oxide Complexes

1983 • 261 citations

Mammalian synthesis of nitrite, nitrate, nitric oxide, and N-nitrosating agents

1988 • 243 citations

Reactions of nitric oxide with cytochrome c oxidase

1980 • 232 citations

Paramagnetic Resonance Study of Nitric Oxide Hemoglobin

1968 • 231 citations

Haem‐Dependent Activation of Guanylate Cyclase and Cyclic GMP Formation by Endogenous Nitric Oxide: A Unique Transduction Mechanism for Transcellular Signaling

1990 • 230 citations

Oxidation and reduction of hemoproteins by trioxodinitrate(II). The role of nitrosyl hydride and nitrite

1988 • 212 citations

Mammalian nitrate biosynthesis: incorporation of 15NH3 into nitrate is enhanced by endotoxin treatment.

1983 • 211 citations

Engineering of protein bound iron‐sulfur clusters

1989 • 211 citations

Activation of purified soluble guanylate cyclase by protoporphyrin IX.

1982 • 206 citations

An Electron Spin Resonance Study of Some Complexes of Iron, Nitric Oxide, and Anionic Ligands

1965 • 191 citations

IFN-γ-activated macrophages: Detection by electron paramagnetic resonance of complexes between L-Arginine-derived nitric oxide and non-heme iron proteins

1990 • 185 citations

Blood nitrates and infantile methemoglobinemia

1982 • 175 citations

Possible involvement of S‐nitrosothiols in the activation of guanylate cyclase by nitroso compounds

1980 • 173 citations

[17O]Water and nitric oxide binding by protocatechuate 4,5-dioxygenase and catechol 2,3-dioxygenase. Evidence for binding of exogenous ligands to the active site Fe2+ of extradiol dioxygenases.

1985 • 162 citations

The nitroprusside ion

1967 • 152 citations

Binding of 17O-labeled substrate and inhibitors to protocatechuate 4,5-dioxygenase-nitrosyl complex. Evidence for direct substrate binding to the active site Fe2+ of extradiol dioxygenases.

1986 • 150 citations

Electron spin resonance of iron-nitric oxide complexes with amino acids, peptides and proteins

1968 • 144 citations

Nitrous oxide reductase from Pseudomonas stutzeri

1989 • 143 citations

Endothelium-derived nitric oxide: pharmacology and relationship to the actions of organic nitrate esters.

1989 • 142 citations

Equilibrium between six- and five-coordinated hemes in nitrosylhemoglobin: interpretation of electron spin resonance spectra

1976 • 139 citations

Studies of the oxygen binding site of cytochrome P-450. Nitric oxide as a spin-label probe.

1978 • 134 citations

The Effect of Inositol Hexaphosphate on the Kinetics of CO and O2 Binding by Human Hemoglobin

1971 • 133 citations

Electron paramagnetic resonance of nitric oxide-protoheme complexes with some nitrogenous base. Model systems of nitric oxide hemoproteins

1969 • 133 citations

Imidazole, the ligand trans to mercaptide in ferric cytochrome P-450. An EPR study of proteins and model compounds.

1977 • 120 citations

The chemical mechanism of microbioal denitrification

1982 • 118 citations

Electron paramagnetic studies of nitric oxide haemoglobin derivatives: Isolated subunits and nitric oxide hybrids

1973 • 117 citations

On the influence of allosteric effectors on the electron paramagnetic spectrum of nitric oxide hemoglobin

1972 • 115 citations

Reaction of Nitric Oxide with Hæmoglobin and Methæmoglobin

1937 • 114 citations

Structure of cytochrome a3-Cua3 couple in cytochrome c oxidase as revealed by nitric oxide binding studies.

1979 • 112 citations

Essential role of nitric oxide in descending inhibition in the rat proximal colon

1990 • 111 citations

Nitric oxide formation during microsomal hepatic denitration of glyceryl trinitrate: Involvement of cytochrome P-450

1989 • 109 citations

Biotransformation of nitric oxide.

1987 • 109 citations

Purification and properties of heme-deficient hepatic soluble guanylate cyclase: Effects of heme and other factors on enzyme activation by NO, NO-heme, and protoporphyrin IX

1982 • 107 citations

Nitrosyl-Hemoglobin Formation in the Blood of Animals Exposed to Nitric Oxide

1975 • 105 citations

Magnetic Dipole-Dipole Coupled Cu(II) Pairs in Nitric Oxide-Treated Tyrosinase: A Structural Relationship Between the Active Sites of Tyrosinase and Hemocyanin

1973 • 101 citations

Nitrosyliron(III) hemoglobin: autoreduction and spectroscopy

1986 • 98 citations

Electron spin resonance study of the role of NO . catalase in the activation of guanylate cyclase by NaN3 and NH2OH. Modulation of enzyme responses by heme proteins and their nitrosyl derivatives.

1979 • 96 citations

Electron Spin Resonance of Fe(CN)5NO3− and Fe(CN)5NOH2−

1966 • 95 citations

The nitric oxide complex of ferrous soybean lipoxygenase-1. Substrate, pH, and ethanol effects on the active-site iron.

1987 • 94 citations

Isolation and identification of a paramagnetic complex from the livers of carcinogen-treated rats

1970 • 92 citations

Formation by NO of nitrosyl adducts of redox components of the Photosystem II reaction center. I. NO binds to the acceptor-side non-heme iron

1990 • 92 citations

Electron Paramagnetic Resonance Study of the Stereochemistry of Nitrosylhemoglobin

1969 • 91 citations

Electron paramagnetic resonance study of nitrosylmyoglobin

1971 • 90 citations

Reactions of nitric oxide with methemoglobin

1969 • 87 citations

Nitrous oxide cycling in Lake Vanda, Antarctica

1981 • 87 citations

The dissociation of NO from nitrosylhemoglobin.

1978 • 86 citations

A novel kind of multi-copper protein as terminal oxidoreductase of nitrous oxide respiration inPseudomonas perfectomarinus

1982 • 86 citations

Biochemical and biophysical studies on cytochrome aa3 III. The EPR spectrum of NO-ferrocytochrome a3

1971 • 85 citations

Electron paramagnetic resonance studies of nitric oxide hemoglobin derivatives. I. Human hemoglobin subunits

1969 • 81 citations

An interpretation of the three line EPR spectrum of nitric oxide hemeproteins and related model systems:

1975 • 81 citations

Autocatalytic oxidation of hemoglobin induced by nitrite: Activation and chemical inhibition

1985 • 81 citations

Redox reactivity of iron(III) porphyrins and heme proteins with nitric oxide. Nitrosyl transfer to carbon, oxygen, nitrogen and sulfur

1990 • 80 citations

Reactions of nitric oxide with tree and fungal laccase

1981 • 74 citations

Inhibitors of nitrogen fixation in extracts from Clostridium pasteurianum

1965 • 72 citations

Comparison of carbon monoxide, nitric oxide, and nitrite as inhibitors of the nitrogenase from Clostridium pasteurianum

1981 • 70 citations

Conformational Isomers of Nitrosyl‐haemoglobin

1972 • 66 citations

Nitric oxide adducts of the binuclear iron site of hemerythrin: spectroscopy and reactivity

1988 • 64 citations

[FREE RADICALS OF A NEW TYPE IN YEAST CELLS].

1965 • 64 citations

Preparation and Kinetic Properties of Intermediates in the Reaction of Hemoglobin with Ligands

1966 • 63 citations

Evidence from isotope labeling studies for a sequential mechanism for dissimilatory nitrite reduction

1988 • 62 citations

Denitrification: a question of the control and organization of electron and ion transport

1987 • 62 citations

The interaction between nitrogen oxides and hemoglobin and endothelium-derived relaxing factor

1989 • 60 citations

Nitrite inhibition of nitrogenase from soybean bacteroids

1980 • 59 citations

The nature of the nitric oxide complexes of lipoxygenase

1979 • 59 citations

Computer simulation of the EPR spectra of mononuclear and dipolar coupled Cu(II) ions in nitric oxide- and nitrite-treated hemocyanins and tyrosinase

1974 • 59 citations

Chloroperoxidase. P-450 type absorption in the absence of sulfhydryl groups

1975 • 58 citations

Denitrification and nitrite reduction: Pseudomonas aeruginosa nitrite-reductase

1984 • 57 citations

Oxidation reaction of human oxyhemoglobin with nitrite: a reexamination

1987 • 55 citations

Tetranuclear and binuclear iron-sulfur clusters in succinate dehydrogenase: A method of iron quantitation by formation of paramagnetic complexes

1976 • 55 citations

Nitric oxide dissociation from trioxodinitrate(II) in aqueous solution

1984 • 54 citations

Electron Spin Resonance of Nitric Oxide-Hemoglobin Complexes in Solution

1962 • 51 citations

Electron nuclear double resonance and electron paramagnetic resonance study on the structure of the NO-ligated heme alpha 3 in cytochrome c oxidase.

1983 • 49 citations

EPR studies of the photodissociation reactions of cytochrome c oxidase-nitric oxide complexes

1982 • 49 citations

Isotope labeling studies on the mechanism of N-N bond formation in denitrification.

1986 • 48 citations

The interaction of nitric oxide with soybean lipoxygenase-1

1978 • 48 citations

Nitric Oxide Complex of Cytochrome c' in Cells of Denitrifying Bacteria

1988 • 47 citations

Stereochemical Control of Valence and Its Application to the Reduction of Coordinated NO and N ₂

1972 • 46 citations

Chain nonequivalence in binding of nitric oxide to hemoglobin

1978 • 46 citations

The effects of 2-acetylaminofluorene and nitrite on free radicals and carcinogenesis in rat liver.

1970 • 46 citations

Reaction of nitric oxide with cobalt(II) ammine complexes and other reducing agents

1967 • 45 citations

Role of Nitrogen Dioxide in the Biosynthesis of Nitrosamines in Mice

1980 • 45 citations

Electron paramagnetic resonance of nitric oxide cytochrome c

1969 • 43 citations

The interaction of nitric oxide with ascorbate oxidase

1975 • 41 citations

The inorganic biochemistry of nitrogen bioenergetic processes

1979 • 40 citations

Chain non-equivalence in nitric oxide binding to hemoglobin

1973 • 39 citations

On the ligand field of redox active non-heme iron in proteins

1965 • 38 citations

Metabolism of Nitrous Oxide by Human and Rat Intestinal Contents

1980 • 38 citations

62. Structure and reactivity of transition-metal complexes with polyatomic ligands. Part I. Electron spin resonance spectra of [Mn(CN)5NO]2? and [Fe(CN)5NO]3?

1965 • 36 citations

Interactions of the anesthetic nitrous oxide with bovine heart cytochrome c oxidase. Effects on protein structure, oxidase activity, and other properties.

1988 • 36 citations

Resonance Raman and EPR of nitrosyl human hemoglobin and chains, carp hemoglobin, and model compounds. Implications for the nitrosyl heme coordination state.

1979 • 36 citations

Selective alterations in responsiveness of guanylate cyclase to activation by nitroso compounds during enzyme purification

1981 • 36 citations

Nitrosation and nitrosylation of haemoproteins and related compounds. Part 4. Pentaco-ordinate nitrosylprotohaem as the pigment of cooked cured meat. Direct evidence from e.s.r. spectroscopy

1980 • 36 citations

Bioconversion of glyceryl trinitrate into mononitrates by Geotrichum candidum

1989 • 36 citations

Nitrosyl cytochrome c oxidase. Formation and properties of mixed valence enzyme.

1988 • 36 citations

Binding of nitric oxide to reduced L-tryptophan-2,3-dioxygenase as studied by electron paramagnetic resonance.

1976 • 34 citations

A Spectroscopic Study of Nitric-Oxide-Treated Ceruloplasmin

1978 • 34 citations

Reaction of hemoglobin with nitric oxide and nitrogen dioxide in mice

1980 • 34 citations

A spin 3/2 ferrous—nitric oxide derivative of an iron‐containing moiety associated with Neurospora crassa and higher plant mitochondria

1978 • 34 citations

The Reaction of Nitrogen Monoxide and of Nitrite with Deoxyhaemocyanin and Methaemocyanin of Helix pomatia

1979 • 33 citations

Electron paramagnetic resonance study of ferrous cytochrome P-450scc-nitric oxide complexes: effects of cholesterol and its analogs

1987 • 33 citations

The nitrosyl compounds of ferrous animal haloperoxidases

1984 • 32 citations

Formation of glyceryl 2‐mononitrate by regioselective bioconversion of glyceryl trinitrate: efficiency of the filamentous fungus Phanerochaete chrysosporium

1990 • 26 citations

Stoichiometry of nitrite reduction catalyzed by Pseudomonas aeruginosa nitrite-reductase

1984 • 26 citations

Inhibition of nitrogenase by nitrite and nitric oxide in Rhodopseudomonas sphaeroides f. sp. denitrificans

1987 • 22 citations

EPR studies of nitric oxide complexes of turnip and horseradish peroxidases

1974 • 22 citations

The anesthetic nitrous oxide affects dioxygen utilization by bovine heart and bean seed mitochondrial particles

1987 • 19 citations

Spectral properties of nitric oxide complex of cytochrome c′ from Rhodopseudomonas capsulata B100

1987 • 17 citations

[Nature of a new type of EPR signal observed in neoplastic tissues].

1970 • 15 citations

The reaction of nitric oxide with Rhus vernicifera laccase

1975 • 15 citations

The nitrosyl compound of ferrous lactoperoxidase

1984 • 14 citations

[Incorporation of non-heme iron into mouse liver dinitrosyl complexes in vitro].

1978 • 9 citations

Lipidic nitrosating agents produced from atmospheric nitrogen dioxide and a nitrosamine produced in vivo from amyl nitrite.

1987 • 4 citations

[Presence of 2 closely situated SH-groups in the rhodopsin molecule].

1977 • 3 citations

[Nitrite reduction by NADH, catalyzed by the nitrite reductase of Pseudomonas aeruginosa].

1980 • 1 citations

Deleted Work

1955 • 0 citations