Inhibition of Ribonucleotide Reductase by Nitric Oxide Derived from Thionitrites: Reversible Modifications of Both Subunits

A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds

1993 • 2,423 citations

Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells.

1989 • 1,747 citations

Reversible binding of Pi by beef heart mitochondrial adenosine triphosphatase.

1977 • 1,579 citations

Role of nitric oxide synthesis in macrophage antimicrobial activity

1991 • 1,547 citations

S-nitrosylation of proteins with nitric oxide: synthesis and characterization of biologically active compounds.

1992 • 1,454 citations

Nitric oxide synthase structure and mechanism

1993 • 1,342 citations

Peroxynitrite, a cloaked oxidant formed by nitric oxide and superoxide

1992 • 1,319 citations

Nitric oxide circulates in mammalian plasma primarily as an S-nitroso adduct of serum albumin.

1992 • 1,237 citations

Reduction of Ribonucleotides

1979 • 1,170 citations

Vasorelaxant properties of the endothelium-derived relaxing factor more closely resemble S-nitrosocysteine than nitric oxide

1990 • 996 citations

Measurement of nitric oxide in biological models

1993 • 925 citations

Oxidation of nitric oxide in aqueous solution to nitrite but not nitrate: comparison with enzymatically formed nitric oxide from L-arginine.

1993 • 832 citations

The physiological role of nitric oxide

1993 • 541 citations

Inhibition of tumor cell ribonucleotide reductase by macrophage-derived nitric oxide.

1991 • 436 citations

Reactions of nitrogen dioxide in aqueous model systems: Oxidation of tyrosine units in peptides and proteins

1985 • 333 citations

Inactivation of ribonucleotide reductase by nitric oxide

1991 • 331 citations

Alterations of ribonucleotide reductase activity following induction of the nitrite-generating pathway in adenocarcinoma cells.

1990 • 284 citations

An unusually stable thionitrite from N-acetyl-D,L-penicillamine; X-ray crystal and molecular structure of 2-(acetylamino)-2-carboxy-1,1-dimethylethyl thionitrite

1978 • 281 citations

Generation of EPR-detectable nitrosyl-iron complexes in tumor target cells cocultured with activated macrophages

1991 • 280 citations

[4] Preparation of derivatives of ferrous and ferric hemoglobin

1981 • 245 citations

Cell cycle-dependent regulation of mammalian ribonucleotide reductase. The S phase-correlated increase in subunit M2 is regulated by de novo protein synthesis.

1984 • 244 citations

Kinetics of nitric oxide autoxidation in aqueous solution.

1994 • 225 citations

A model for the role of multiple cysteine residues involved in ribonucleotide reduction: amazing and still confusing

1992 • 210 citations

Role of ribonucleotide reductase in inhibition of mammalian cell growth by potent iron chelators.

1993 • 199 citations

Continual presence of oxygen and iron required for mammalian ribonucleotide reduction: Possible regulation mechanism

1983 • 190 citations

NAD(P)H:flavin oxidoreductase of Escherichia coli. A ferric iron reductase participating in the generation of the free radical of ribonucleotide reductase.

1987 • 190 citations

Quenching of the tyrosyl free radical of ribonucleotide reductase by nitric oxide. Relationship to cytostasis induced in tumor cells by cytotoxic macrophages.

1994 • 187 citations

Early loss of the tyrosyl radical in ribonucleotide reductase of adenocarcinoma cells producing nitric oxide

1992 • 144 citations

Trapping of Nitric Oxide by Nitronyl Nitroxides: An Electron Spin Resonance Investigation

1993 • 141 citations

The ribonucleotide reductases — A unique group of metalloenzymes essential for cell proliferation

1983 • 138 citations

Nitric oxide/nucleophile complexes inhibit the in vitro proliferation of A375 melanoma cells via nitric oxide release.

1993 • 137 citations

Role of ribonucleotide reductase in expression of the neoplastic program

1981 • 136 citations

Reduction and loss of the iron center in the reaction of the small subunit of mouse ribonucleotide reductase with hydroxyurea

1993 • 135 citations

New Thionitrites: Synthesis, Stability, and Nitric Oxide Generation

1994 • 121 citations

Reactions of nitric oxide with phenolic antioxidants and phenoxyl radicals

1993 • 105 citations

Reduced forms of the iron-containing small subunit of ribonucleotide reductase from Escherichia coli

1989 • 82 citations

Interaction of Nitrite with Proteins at Gastric pH

1974 • 80 citations

Enzymatic Regulation of the Radical Content of the Small Subunit of Escherichia coli Ribonucleotide Reductase Involving Reduction of Its Redox Centers

1989 • 80 citations

Enzymic modification of a tyrosine residue to a stable free radical in ribonucleotide reductase.

1983 • 60 citations

Molecular cloning and expression of the functional gene encoding the M2 subunit of mouse ribonucleotide reductase: a new dominant marker gene.

1989 • 46 citations

Reduction of the Fe(III)-tyrosyl radical center of Escherichia coli ribonucleotide reductase by dithiothreitol.

1990 • 38 citations

Radical formation in the dimeric small subunit of ribonucleotide reductase requires only one tyrosine 122.

1988 • 29 citations

Conversion of nitric oxide into a nitroxide radical using 2,3-dimethylbutadiene and 2,5-dimethylhexadiene

1993 • 11 citations