Growth and viability of macrophages continuously stimulated to produce nitric oxide

Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production.

1988 • 2,865 citations

Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells.

1989 • 1,747 citations

Regulation of biosynthesis of nitric oxide.

1994 • 1,698 citations

Role of nitric oxide synthesis in macrophage antimicrobial activity

1991 • 1,547 citations

NO at work

1994 • 1,493 citations

Nitric Oxide Activation of Poly(ADP-Ribose) Synthetase in Neurotoxicity

1994 • 1,138 citations

Chronic infections and inflammatory processes as cancer risk factors: possible role of nitric oxide in carcinogenesis

1994 • 1,065 citations

Nitric oxide-mediated apoptosis in murine peritoneal macrophages

1993 • 782 citations

Induction of nitrite/nitrate synthesis in murine macrophages by BCG infection, lymphokines, or interferon-gamma.

1987 • 722 citations

Simulation of the diffusion and reaction of endogenously produced nitric oxide.

1994 • 699 citations

Nitric oxide-mediated apoptosis in murine peritoneal macrophages.

1993 • 674 citations

DNA strand breakage, activation of poly (ADP-ribose) synthetase, and cellular energy depletion are involved in the cytotoxicity of macrophages and smooth muscle cells exposed to peroxynitrite.

1996 • 630 citations

Expression of the nitric oxide synthase gene in mouse macrophages activated for tumor cell killing. Molecular basis for the synergy between interferon-gamma and lipopolysaccharide.

1993 • 623 citations

Differentiation of murine macrophages to express nonspecific cytotoxicity for tumor cells results in L-arginine-dependent inhibition of mitochondrial iron-sulfur enzymes in the macrophage effector cells.

1988 • 592 citations

EPR demonstration of iron-nitrosyl complex formation by cytotoxic activated macrophages.

1990 • 512 citations

Inducible nitric oxide synthase, nitrotyrosine, and apoptosis in Helicobacter pylori gastritis: effect of antibiotics and antioxidants.

1996 • 494 citations

Inflammation: Basic Principles and Clinical Correlates

1993 • 473 citations

Murine cytotoxic activated macrophages inhibit aconitase in tumor cells. Inhibition involves the iron-sulfur prosthetic group and is reversible.

1986 • 421 citations

Feedback inhibition of nitric oxide synthase activity by nitric oxide

1993 • 396 citations

Potential genotoxicity of chronically elevated nitric oxide: A review

1995 • 385 citations

Activated murine macrophages induce apoptosis in tumor cells through nitric oxide-dependent or -independent mechanisms.

1994 • 372 citations

Synthesis of nitrite and nitrate in murine macrophage cell lines.

1987 • 335 citations

Peroxynitrite-mediated DNA strand breakage activates poly-adenosine diphosphate ribosyl synthetase and causes cellular energy depletion in macrophages stimulated with bacterial lipopolysaccharide.

1996 • 322 citations

Suppression of adjuvant-induced arthritis by selective inhibition of inducible nitric oxide synthase

1995 • 306 citations

Nitric Oxide Induces Oxidative Damage in Addition to Deamination in Macrophage DNA

1995 • 258 citations

The role of nitric oxide (NO·) in the carcinogenic process

1996 • 225 citations

Nitric oxide-induced apoptosis in RAW 264.7 macrophages is antagonized by protein kinase C- and protein kinase A-activating compounds.

1995 • 178 citations

The Nitric Oxide/Superoxide Assay

1997 • 167 citations

Kinetic Analysis of the Fate of Nitric Oxide Synthesized by Macrophages in Vitro

1995 • 160 citations

No-induced oxidative stress and glutathione metabolism in rodent and human cells

1996 • 158 citations

Vesicle membrane association of nitric oxide synthase in primary mouse macrophages.

1995 • 140 citations

Inactivation of nitric oxide synthase after prolonged incubation of mouse macrophages with IFN-gamma and bacterial lipopolysaccharide.

1994 • 138 citations

Synergistic cooperation between T cell lymphokines for induction of the nitric oxide synthase gene in murine peritoneal macrophages.

1993 • 134 citations

Superoxide Formation and Macrophage Resistance to Nitric Oxide-mediated Apoptosis

1997 • 121 citations

Mutagenesis associated with nitric oxide production in transgenic SJL mice

1996 • 97 citations

Modulation of glucose metabolism in macrophages by products of nitric oxide synthase

1993 • 73 citations

Induced RAW 264.7 macrophages express soluble and particulate nitric oxide synthase: inhibition by transforming growth factor-ß

1992 • 72 citations

Heat shock proteins and macrophage resistance to the toxic effects of nitric oxide

1996 • 72 citations

A lipopolysaccharide (LPS)-resistant mutant isolated from a macrophagelike cell line, J774.1, exhibits an altered activated-macrophage phenotype in response to LPS

1991 • 50 citations

Nitrotyrosine formation, apoptosis, and oxidative damage: relationships to nitric oxide production in SJL mice bearing the RcsX tumor.

1997 • 49 citations

Repeated induction of nitric oxide synthase and leishmanicidal activity in murine macrophages

1993 • 43 citations

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