Peroxynitrite formation from macrophage-derived nitric oxide

Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production.

1988 • 2,865 citations

Peroxynitrite oxidation of sulfhydryls.

1991 • 2,479 citations

Peroxynitrite-induced membrane lipid peroxidation: The cytotoxic potential of superoxide and nitric oxide

1991 • 2,215 citations

Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells.

1989 • 1,747 citations

Macrophage oxidation of L-arginine to nitrite and nitrate: nitric oxide is an intermediate

1988 • 1,622 citations

Role of nitric oxide synthesis in macrophage antimicrobial activity

1991 • 1,547 citations

Macrophage Cytotoxicity: Role for L-Arginine Deiminase and Imino Nitrogen Oxidation to Nitrite

1987 • 1,533 citations

Peroxynitrite-mediated tyrosine nitration catalyzed by superoxide dismutase

1992 • 1,499 citations

Biosynthesis and Metabolism of Endothelium-Derived Nitric Oxide

1990 • 1,284 citations

Increased superoxide anion production by immunologically activated and chemically elicited macrophages

1978 • 823 citations

Oxidants from phagocytes: agents of defense and destruction

1984 • 803 citations

Kinetics of superoxide dismutase- and iron-catalyzed nitration of phenolics by peroxynitrite

1992 • 758 citations

Macrophage killing of Leishmania parasite in vivo is mediated by nitric oxide from L-arginine.

1990 • 751 citations

Induction of nitrite/nitrate synthesis in murine macrophages by BCG infection, lymphokines, or interferon-gamma.

1987 • 722 citations

Activated macrophages destroy intracellular Leishmania major amastigotes by an L-arginine-dependent killing mechanism.

1990 • 690 citations

Fibrogenic cytokines: the role of immune mediators in the development of scar tissue

1991 • 607 citations

N omega-hydroxy-L-arginine is an intermediate in the biosynthesis of nitric oxide from L-arginine.

1991 • 572 citations

Tumor necrosis factor-alpha synergizes with IFN-gamma in mediating killing of Leishmania major through the induction of nitric oxide.

1990 • 531 citations

Synthesis of nitric oxide from <scp>l</scp>-arginine by neutrophils. Release and interaction with superoxide anion

1989 • 529 citations

Activated murine macrophages secrete a metabolite of arginine with the bioactivity of endothelium-derived relaxing factor and the chemical reactivity of nitric oxide.

1989 • 464 citations

Bactericidal activity of peroxynitrite

1992 • 436 citations

Murine cytotoxic activated macrophages inhibit aconitase in tumor cells. Inhibition involves the iron-sulfur prosthetic group and is reversible.

1986 • 421 citations

Peroxynitrite-induced luminol chemiluminescence

1993 • 371 citations

Specific amino acid (L-arginine) requirement for the microbiostatic activity of murine macrophages.

1988 • 337 citations

Nonspecific defence mechanism: the role of nitric oxide

1991 • 325 citations

Macrophage cytotoxicity against schistosomula of Schistosoma mansoni involves arginine-dependent production of reactive nitrogen intermediates.

1989 • 320 citations

Nitrotyrosine as a new marker for endogenous nitrosation and nitration of proteins

1990 • 249 citations

Formation and release of nitric oxide from human neutrophils and HL‐60 cells induced by a chemotactic peptide, platelet activating factor and leukotriene B₄

1989 • 244 citations

Cardioprotection by Cu, Zn-superoxide dismutase is lost at high doses in the reoxygenated heart

1990 • 157 citations

L-arginine-dependent reactive nitrogen intermediates as mediators of tumor cell killing by activated macrophages.

1990 • 155 citations

Urinary nitrate excretion in relation to murine macrophage activation. Influence of dietary L-arginine and oral NG-monomethyl-L-arginine.

1991 • 146 citations

The cardioprotective effect of Mn-superoxide dismutase is lost at high doses in the postischemic isolated rabbit heart

1990 • 132 citations

Regulation of macrophage physiology by L-arginine: role of the oxidative L-arginine deiminase pathway.

1989 • 128 citations

Photolysis of the nitrogen-nitrogen double bond in trioxodinitrate: reaction between triplet oxonitrate(1-) and molecular oxygen to form peroxonitrite

1986 • 108 citations

Contribution of nitric oxide synthase to luminol-dependent chemiluminescence generated by phorbol-ester-activated Kupffer cells

1991 • 102 citations

Comparison of the metabolism of alveolar macrophages from humans, rats, and rabbits: phorbol myristate acetate.

1978 • 40 citations

The chemistry of peroxonitrites. Part III. The reaction of peroxonitrite with nucleophiles in alkali, and other nitrite producing reactions

1971 • 40 citations

Serum factor requirement for reactive oxygen intermediate release by rabbit alveolar macrophages.

1985 • 31 citations

Role of reactive nitrogen intermediate production in alveolar macrophage-mediated cytostatic activity induced by bleomycin lung damage in rats.

1990 • 24 citations

A dual role for calcium in regulation of superoxide generation by stimulated rat alveolar macrophages

1987 • 22 citations