CD4 Effector T Cell Subsets in the Response to Influenza

Two subsets of memory T lymphocytes with distinct homing potentials and effector functions

1999 • 5,659 citations

Genetic Restriction of HIV-1 Infection and Progression to AIDS by a Deletion Allele of the CKR5 Structural Gene

1996 • 2,502 citations

CCR7 Coordinates the Primary Immune Response by Establishing Functional Microenvironments in Secondary Lymphoid Organs

1999 • 2,326 citations

Differential Expression of Chemokine Receptors and Chemotactic Responsiveness of Type 1 T Helper Cells (Th1s) and Th2s

1998 • 2,048 citations

Preferential Localization of Effector Memory Cells in Nonlymphoid Tissue

2001 • 1,922 citations

Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice

1998 • 1,687 citations

T-Cell Function and Migration — Two Sides of the Same Coin

2000 • 1,437 citations

Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naïve cells

2001 • 1,277 citations

Visualizing the generation of memory CD4 T cells in the whole body

2001 • 1,029 citations

Helper T Cell Differentiation Is Controlled by the Cell Cycle

1998 • 862 citations

Naïve CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation

2001 • 861 citations

Dynamics of T Lymphocyte Responses: Intermediates, Effectors, and Memory Cells

2000 • 807 citations

Chemokines in tissue-specific and microenvironment-specific lymphocyte homing

2000 • 643 citations

Requirement for CD44 in Activated T Cell Extravasation into an Inflammatory Site

1997 • 560 citations

In Vivo Detection of Dendritic Cell Antigen Presentation to CD4+ T Cells

1997 • 560 citations

Heterogeneity of intracellular cytokine synthesis at the single-cell level in polarized T helper 1 and T helper 2 populations.

1995 • 554 citations

New fluorescent dyes for lymphocyte migration studies

1990 • 498 citations

In Vivo Activation of Antigen-Specific CD4 T Cells

2001 • 498 citations

Early Programming of T Cell Populations Responding to Bacterial Infection

2000 • 492 citations

Unequal Death in T Helper Cell (Th)1 and Th2 Effectors: Th1, but not Th2, Effectors Undergo Rapid Fas/FasL-mediated Apoptosis

1997 • 460 citations

In vivo effector function of influenza virus-specific cytotoxic T lymphocyte clones is highly specific.

1984 • 439 citations

Effector CD4⁺ and CD8⁺ T‐cell mechanisms in the control of respiratory virus infections

1997 • 430 citations

The Cc Chemokine Thymus-Derived Chemotactic Agent 4 (Tca-4, Secondary Lymphoid Tissue Chemokine, 6ckine, Exodus-2) Triggers Lymphocyte Function–Associated Antigen 1–Mediated Arrest of Rolling T Lymphocytes in Peripheral Lymph Node High Endothelial Venules

2000 • 420 citations

Interleukin 2 regulates its own receptors.

1985 • 414 citations

Effector differentiation is not prerequisite for generation of memory cytotoxic T lymphocytes

2001 • 407 citations

Rapid Turnover of T Lymphocytes in SIV-Infected Rhesus Macaques

1998 • 375 citations

The Ccr7 Ligand ELC (Ccl19) Is Transcytosed in High Endothelial Venules and Mediates T Cell Recruitment

2001 • 367 citations

A role for non-MHC genetic polymorphism in susceptibility to spontaneous autoimmunity

1994 • 347 citations

CCR7 Expression and Memory T Cell Diversity in Humans

2001 • 342 citations

Cell division regulates the T cell cytokine repertoire, revealing a mechanism underlying immune class regulation

1998 • 332 citations

T helper 1 and T helper 2 cells respond differentially to chemokines.

1998 • 309 citations

Measuring the diaspora for virus-specific CD8⁺T cells

2001 • 288 citations

Protection from Respiratory Virus Infections Can Be Mediated by Antigen-Specific Cd4+ T Cells That Persist in the Lungs

2001 • 285 citations

Molecular mechanism of desensitization of the chemokine receptor CCR-5: receptor signaling and internalization are dissociable from its role as an HIV-1 co-receptor

1997 • 252 citations

Cutting Edge: T Helper 1 and T Helper 2 Cells Respond Differentially to Chemokines

1998 • 238 citations

Tracking Salmonella-Specific CD4 T Cells In Vivo Reveals a Local Mucosal Response to a Disseminated Infection

2002 • 226 citations

Structure of the Human Interleukin-2 Receptor Gene

1985 • 219 citations

Differential T Cell Function and Fate in Lymph Node and Nonlymphoid Tissues

2002 • 197 citations

Migration Kinetics and Final Destination of Type 1 and Type 2 CD8 Effector Cells Predict Protection against Pulmonary Virus Infection

1999 • 195 citations

Instruction for Cytokine Expression in T Helper Lymphocytes in Relation to Proliferation and Cell Cycle Progression

1999 • 190 citations

CD4+ T cell effectors can become memory cells with high efficiency and without further division

2001 • 186 citations

Entry of naive CD4 T cells into peripheral lymph nodes requires L-selectin.

1994 • 182 citations

CD44 activation and associated primary adhesion is inducible via T cell receptor stimulation.

1997 • 163 citations

Two Distinct Stages in the Transition from Naive CD4 T Cells to Effectors, Early Antigen-Dependent and Late Cytokine-Driven Expansion and Differentiation

2000 • 161 citations

Antigen-specific T lymphocytes regulate lipopolysaccharide-induced apoptosis of dendritic cells in vivo.

1998 • 133 citations

The CD44-initiated pathway of T-cell extravasation uses VLA-4 but not LFA-1 for firm adhesion

2000 • 126 citations

CD28, Ox-40, LFA-1, and CD4 Modulation of Th1/Th2 Differentiation Is Directly Dependent on the Dose of Antigen

2000 • 126 citations

Influenza virus RNA in the lung and lymphoid tissue of immunologically intact and CD4-depleted mice

1991 • 115 citations

Cutting Edge: Antigen-Specific T Lymphocytes Regulate Lipopolysaccharide-Induced Apoptosis of Dendritic Cells In Vivo

1998 • 110 citations

Functional Flexibility in T Cells

2000 • 93 citations

T cell differentiation: a mechanistic view

2000 • 77 citations

Cell Division Is Not a “Clock” Measuring Acquisition of Competence to Produce IFN-γ or IL-4

2001 • 74 citations

Identification of eight determinants in the hemagglutinin molecule of influenza virus A/PR/8/34 (H1N1) which are recognized by class II-restricted T cells from BALB/c mice

1991 • 53 citations

Location and character of the cellular enzyme that cleaves the hemagglutinin of a virulent avian influenza virus

1992 • 47 citations

Activated T cells from draining lymph nodes and an effector site differ in their responses to TCR stimulation.

1997 • 38 citations

The Hemagglutinin Cleavability of a Virulent Avian Influenza Virus by Subtilisin-like Endoproteases Is Influenced by the Amino Acid Immediately Downstream of the Cleavage Site

1995 • 36 citations