Epitope dominance, competition and T cell affinity maturation

Two subsets of memory T lymphocytes with distinct homing potentials and effector functions

1999 • 5,659 citations

T cell receptor antagonist peptides induce positive selection

1994 • 2,818 citations

Preferential Localization of Effector Memory Cells in Nonlymphoid Tissue

2001 • 1,922 citations

Visualizing the generation of memory CD4 T cells in the whole body

2001 • 1,029 citations

Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo

1994 • 967 citations

Cross-Presentation, Dendritic Cells, Tolerance and Immunity

2001 • 894 citations

Massive Expansion of Antigen-Specific CD8+ T Cells during an Acute Virus Infection

1998 • 794 citations

Induction and Exhaustion of Lymphocytic Choriomeningitis Virus–specific Cytotoxic T Lymphocytes Visualized Using Soluble Tetrameric Major Histocompatibility Complex Class I–Peptide Complexes

1998 • 733 citations

Induction of a CD8+ Cytotoxic T Lymphocyte Response by Cross-priming Requires Cognate CD4+ T Cell Help

1997 • 729 citations

A Kinetic Basis For T Cell Receptor Repertoire Selection during an Immune Response

1999 • 515 citations

TCR-Mediated Internalization of Peptide-MHC Complexes Acquired by T Cells

1999 • 456 citations

Antigen-Specific Development of Primary and Memory T Cells in Vivo

1995 • 444 citations

Identification of a Graft Versus Host Disease-Associated Human Minor Histocompatibility Antigen

1995 • 429 citations

T Cells Compete for Access to Antigen-Bearing Antigen-Presenting Cells

2000 • 423 citations

T Cell Affinity Maturation by Selective Expansion during Infection

1999 • 420 citations

Maternally transmitted histocompatibility antigen of mice: A hydrophobic peptide of a mitochondrially encoded protein

1990 • 324 citations

Dissecting the Multifactorial Causes of Immunodominance in Class I–Restricted T Cell Responses to Viruses

2000 • 312 citations

An inverse relationship between T cell receptor affinity and antigen dose during CD4⁺T cell responsesin vivoandin vitro

1999 • 259 citations

T Cells Can Use Either T Cell Receptor or Cd28 Receptors to Absorb and Internalize Cell Surface Molecules Derived from Antigen-Presenting Cells

2000 • 249 citations

Virus-triggered acquired immunodeficiency by cytotoxic T-cell-dependent destruction of antigen-presenting cells and lymph follicle structure.

1991 • 231 citations

T cells down-modulate peptide-MHC complexes on APCs in vivo

2001 • 227 citations

A Role for Perforin in Downregulating T-Cell Responses during Chronic Viral Infection

1999 • 227 citations

Cutting Edge: CTLs Rapidly Capture Membrane Fragments from Target Cells in a TCR Signaling-Dependent Manner

2001 • 220 citations

Respiratory syncytial virus infection suppresses lung CD8+ T-cell effector activity and peripheral CD8+ T-cell memory in the respiratory tract

2002 • 217 citations

Expression of the Serpin Serine Protease Inhibitor 6 Protects Dendritic Cells from Cytotoxic T Lymphocyte–Induced Apoptosis

2001 • 205 citations

Identification of classical minor histocompatibility antigen as cell-derived peptide

1990 • 196 citations

Cutting Edge: CD4+ T Cell Control of CD8+ T Cell Reactivity to a Model Tumor Antigen

2000 • 168 citations

Competition Between CTL Narrows the Immune Response Induced by Prime-Boost Vaccination Protocols

2002 • 165 citations

The Granzyme B Inhibitor, Protease Inhibitor 9, Is Mainly Expressed by Dendritic Cells and at Immune-Privileged Sites

2001 • 151 citations

Optimal lymphocytic choriomeningitis virus sequences restricted by H-2Db major histocompatibility complex class I molecules and presented to cytotoxic T lymphocytes

1995 • 121 citations

Regulatory Mechanisms in the Immune Response to Cell-surface Antigens

1977 • 118 citations

Identification of conserved T cell receptor CDR3 residues contacting known exposed peptide side chains from a major histocompatibility complex class I‐bound determinant

1993 • 116 citations

Immunodominance in Virus-Induced CD8⁺T-Cell Responses Is Dramatically Modified by DNA Immunization and Is Regulated by Gamma Interferon

2002 • 109 citations

Visualizing T Cell Competition for Peptide/MHC Complexes

2000 • 107 citations

Qualitative Differences Between Naive and Memory T Cells Make a Major Contribution to the More Rapid and Efficient Memory CD8+ T Cell Response

1998 • 103 citations

Specific binding of alloantigens to T cells activated in the mixed lymphocyte reaction.

1976 • 98 citations

Functionally distinct CD8+ memory T cell subsets in persistent EBV infection are differentiated by migratory receptor expression

2000 • 95 citations

Functional cooperation between T helper cell determinants

2000 • 87 citations

Perforin-independent regulation of dendritic cell homeostasis by CD8+ T cellsin vivo: implications for adaptive immunotherapy

2001 • 71 citations

T cell competition for the antigen-presenting cell as a model for immunodominance in the cytotoxic T lymphocyte response against minor histocompatibility antigens

1999 • 68 citations

Immunodominance in the CTL Response Against Minor Histocompatibility Antigens: Interference Between Responding T Cells, Rather than with Presentation of Epitopes

1998 • 64 citations

Specialization, Tolerance, Memory, Competition, Latency, and Strife among T Cells

1992 • 57 citations

Superdominance Among Immunodominant H-2Kb-Restricted Epitopes and Reversal by Dendritic Cell-Mediated Antigen Delivery

1998 • 56 citations

Avoiding Tolerance Against Prostatic Antigens With Subdominant Peptide Epitopes

2001 • 51 citations

The Immunodominant, Ld-Restricted T Cell Response to Hepatitis B Surface Antigen (HBsAg) Efficiently Suppresses T Cell Priming to Multiple Dd-, Kd-, and Kb-Restricted HBsAg Epitopes

2002 • 45 citations

Cutting Edge: Competition for APC by CTLs of Different Specificities Is Not Functionally Important During Induction of Antiviral Responses

2002 • 45 citations

Associative Control of the Immune Response to Cell Surface Antigens

1976 • 44 citations

Human dendritic cells genetically engineered to express a melanoma polyepitope DNA vaccine induce multiple cytotoxic T-cell responses.

2001 • 39 citations

Functional differences between influenza A-specific cytotoxic T lymphocyte clones expressing dominant and subdominant TCR

2001 • 38 citations

Recombinant Canarypox Vaccine-Elicited CTL Specific for Dominant and Subdominant Simian Immunodeficiency Virus Epitopes in Rhesus Monkeys

2002 • 37 citations

Dominant and cryptic antigens in the MHC class I restricted T cell response across a complex minor histocompatibility barrier: analysis and mapping by elution of cellular peptides

1995 • 34 citations

Cutting Edge: Chemical Dominance Does Not Relate to Immunodominance: Studies of the CD4+ T Cell Response to a Model Antigen

2002 • 31 citations

Immunization with dendritic cells breaks immunodominance in CTL responses against minor histocompatibility and synthetic peptide antigens

1999 • 19 citations

Prior Vaccination Increases the Epitopic Breadth of the Cytotoxic T-Lymphocyte Response That Evolves in Rhesus Monkeys following a Simian-Human Immunodeficiency Virus Infection

2002 • 18 citations

Memory in helper T cells of minor histocompatibility antigens, revealed in vivo by alloimmunizations in combination with Thy‐1 antigen

1992 • 18 citations

Modulation of Thy-1 alloantibody responses: donor cell-associated H-2 inhibition and augmentation without recipient Ir gene control.

1981 • 11 citations

Down‐regulation of class II major histocompatibility complex molecules on antigen presenting cells after interaction with helper T cells

1995 • 11 citations

Selective functional depletion of HIV gp120 peptides complexed with MHC from antigen-presenting cells engaged with specific T lymphocytes.

1992 • 10 citations

Antigenic Competition

1971 • 8 citations

MHC multimerization, antigen expression and the induction of APC amnesia in the developing immune response

1999 • 7 citations