The Transcriptional Inhibitors, Actinomycin D and α-Amanitin, Activate the HIV-1 Promoter and Favor Phosphorylation of the RNA Polymerase II C-terminal Domain

Firefly luciferase gene: structure and expression in mammalian cells.

1987 • 3,088 citations

A Novel CDK9-Associated C-Type Cyclin Interacts Directly with HIV-1 Tat and Mediates Its High-Affinity, Loop-Specific Binding to TAR RNA

1998 • 1,213 citations

A very strong enhancer is located upstream of an immediate early gene of human cytomegalovirus

1985 • 1,155 citations

The general transcription factors of RNA polymerase II.

1996 • 1,010 citations

Specific Inhibition of Nuclear RNA Polymerase II by α-Amanitin

1970 • 856 citations

Transcription elongation factor P-TEFb is required for HIV-1 Tat transactivation in vitro

1997 • 692 citations

Comparison of three actin-coding sequences in the mouse; Evolutionary relationships between the actin genes of warm-blooded vertebrates

1986 • 678 citations

CONTROL OF RNA INITIATION AND ELONGATION AT THE HIV-1 PROMOTER

1994 • 613 citations

Transcriptional activation and chromatin remodeling of the HIV-1 promoter in response to histone acetylation.

1996 • 571 citations

P-TEFb kinase is required for HIV Tat transcriptional activation in vivo and in vitro

1997 • 539 citations

Actinomycin and DNA transcription.

1985 • 535 citations

Inhibition of RNA synthesis by actinomycin D: Characteristic dose‐response of different RNA species

1970 • 531 citations

Human papillomavirus 16 E6 expression disrupts the p53-mediated cellular response to DNA damage.

1993 • 526 citations

Identification of multiple cyclin subunits of human P-TEFb

1998 • 512 citations

Reversible Phosphorylation of the C-terminal Domain of RNA Polymerase II

1996 • 498 citations

α-Amanitin: A specific inhibitor of one of two DNA-dependent RNA polymerase activities from calf thymus

1970 • 488 citations

Enhanced Transcription of c- myc in Bursal Lymphoma Cells Requires Continuous Protein Synthesis

1985 • 469 citations

The interaction between HIV-1 Tat and human cyclin T1 requires zinc and a critical cysteine residue that is not conserved in the murine CycT1 protein

1998 • 428 citations

Temporal Regulation of RNA Polymerase II by Srb10 and Kin28 Cyclin-Dependent Kinases

1998 • 400 citations

HIV-1 Regulatory/Accessory Genes: Keys to Unraveling Viral and Host Cell Biology

1998 • 392 citations

Role of DNA-Dependent RNA Polymerase III in the Transcription of the tRNA and 5S RNA Genes

1974 • 357 citations

HIV-1 Auxiliary Proteins: Making Connections in a Dying Cell

1998 • 328 citations

The RNA polymerase II holoenzyme and its implications for gene regulation

1995 • 297 citations

HIV-1 Tat protein promotes formation of more-processive elongation complexes.

1991 • 295 citations

Human immunodeficiency virus long terminal repeat responds to T-cell activation signals.

1987 • 292 citations

Activation of Integrated Provirus Requires Histone Acetyltransferase

1998 • 284 citations

Recruitment of a protein complex containing Tat and cyclin T1 to TAR governs the species specificity of HIV-1 Tat

1998 • 263 citations

Activation of human immunodeficiency virus type 1 by DNA damage in human cells

1988 • 256 citations

In vivo degradation of RNA polymerase II largest subunit triggered by alpha-amanitin

1996 • 249 citations

Novel Substrate Specificity of the Histone Acetyltransferase Activity of HIV-1-Tat Interactive Protein Tip60

1997 • 234 citations

Absolute dependence on kappa B responsive elements for initiation and Tat-mediated amplification of HIV transcription in blood CD4 T lymphocytes.

1995 • 233 citations

U.v.-induced nuclear accumulation of p53 is evoked through DNA damage of actively transcribed genes independent of the cell cycle.

1994 • 227 citations

The multiple roles of transcription/repair factor TFIIH

1996 • 227 citations

Taking a new TAK on Tat transactivation

1997 • 206 citations

Tumor necrosis factor-induced apoptosis during the poisoning of mice with hepatotoxins

1997 • 203 citations

The HIV transactivator TAT binds to the CDK-activating kinase and activates the phosphorylation of the carboxy-terminal domain of RNA polymerase II

1997 • 193 citations

Identification of the active region of the DNA synthesis inhibitory gene p21Sdi1/CIP1/WAF1.

1995 • 186 citations

HIV enhancer activity perpetuated by NF-κB induction on infection of monocytes

1991 • 186 citations

TheKIN28Gene is Required both for RNA Polymerase II Mediated Transcription and Phosphorylation of the Rpb1p CTD

1995 • 185 citations

Complete nucleotide sequence of mouse 18 S rRNA gene: comparison with other available homologs

1984 • 180 citations

The Transcriptional Elongation Inhibitor 5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole Inhibits Transcription Factor IIH-associated Protein Kinase

1995 • 178 citations

Two transcriptional activators, CCAAT-box-binding transcription factor and heat shock transcription factor, interact with a human hsp70 gene promoter.

1987 • 173 citations

TAK, an HIV Tat-associated kinase, is a member of the cyclin-dependent family of protein kinases and is induced by activation of peripheral blood lymphocytes and differentiation of promonocytic cell lines

1997 • 172 citations

Constitutively Expressed Rat mRNA Encoding a 70-Kilodalton Heat-Shock-Like Protein

1985 • 164 citations

A CTD function linking transcription to splicing

1997 • 160 citations

Inhibition of RNA Polymerase II Transcription Causes Chromatin Decondensation, Loss of Nucleolar Structure, and Dispersion of Chromosomal Domains

1996 • 150 citations

HIV-1 Tat binds TAF_II250 and represses TAF_II250-dependent transcription of major histocompatibility class I genes

1998 • 136 citations

The multiple roles of transcription/repair factor TFIIH

1996 • 136 citations

Characterisation of human cyclin G1 and G2: DNA damage inducible genes.

1996 • 128 citations

The Regulation of Human Immunodeficiency Virus Type‐1 Gene Expression

1996 • 123 citations

Topoisomerase poisons activate the transcription factor NF-kappaB in ACH-2 and CEM cells

1996 • 123 citations

Inhibitors of transcription such as 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole and isoquinoline sulfonamide derivatives (H-8 and H-7) promote dephosphorylation of the carboxyl-terminal domain of RNA polymerase II largest subunit.

1994 • 122 citations

The Human Immunodeficiency Virus Transactivator Tat Interacts with the RNA Polymerase II Holoenzyme

1997 • 111 citations

p53-Dependent Elevation of p21^Waf1 Expression by UV Light Is Mediated through mRNA Stabilization and Involves a Vanadate-Sensitive Regulatory System

1998 • 106 citations

A microtransfection method using the luciferase-encoding reporter gene for the assay of human immunodeficiency virus LTR promoter activity

1990 • 104 citations

Activation of the HIV-1 Long Terminal Repeat by Cytokines and Environmental Stress Requires an Active CSBP/p38 MAP Kinase

1996 • 103 citations

Activation of HIV-1 Long Terminal Repeat Transcription and Virus Replication via NF-κB-dependent and -independent Pathways by Potent Phosphotyrosine Phosphatase Inhibitors, the Peroxovanadium Compounds

1997 • 86 citations

Drosophila Cdk8, a kinase partner of cyclin C that interacts with the large subunit of RNA polymerase II.

1996 • 85 citations

A Polymerase Switch in the Synthesis of rRNA in Saccharomyces cerevisiae

1995 • 79 citations

Effects of integration and replication on transcription of the HIV-1 long terminal repeat.

1993 • 79 citations

Characterization of the inducer of short transcripts, a human immunodeficiency virus type 1 transcriptional element that activates the synthesis of short RNAs.

1993 • 74 citations

Viral latency in HIV disease

1995 • 74 citations

Activation of a Diphtheria Toxin A Gene by Expression of Human Immunodeficiency Virus-1 Tat and Rev Proteins in Transfected Cells

1991 • 62 citations

Transfer of Tat and release of TAR RNA during the activation of the human immunodeficiency virus type-1 transcription elongation complex

1997 • 60 citations

Heat-shock inactivation of the TFIIH-associated kinase and change in the phosphorylation sites on the C-terminal domain of RNA polymerase II

1997 • 58 citations

Phosphorylation of the RNA polymerase II largest subunit during heat shock and inhibition of transcription in hela cells

1994 • 57 citations

Studies on the inhibition by α-amanitin of single-step addition reactions and productive RNA synthesis catalysed by wheat-germ RNA polymerase II

1989 • 54 citations

Regulatory targets in the RNA polymerase II holoenzyme

1998 • 54 citations

Promoter Activity of Tat at Steps Subsequent to TATA-Binding Protein Recruitment

1997 • 53 citations

Induction of Sp1 Phosphorylation and NF-κB-Independent HIV Promoter Domain Activity in T Lymphocytes Stimulated by Okadaic Acid

1995 • 53 citations

Regulation of Carboxyl-terminal Domain Phosphatase by HIV-1 Tat Protein

1998 • 48 citations

The proliferation-associated early response gene p22/PRG1 is a novel p53 target gene

1998 • 45 citations

A Novel LBP-1-mediated Restriction of HIV-1 Transcription at the Level of Elongation in Vitro

1995 • 44 citations

Initiation inhibition and reinitiation of the synthesis of heterogeneous nuclear RNA in living cells

1976 • 42 citations

Heat-shock Induction of the Human Immunodeficiency Virus Long Terminal Repeat

1988 • 41 citations

Actinomycin D Stimulates the Transcription of rRNA Minigenes Transfected into Mouse Cells

1995 • 37 citations

The Human Immunodeficiency Virus Type-1 Long Terminal Repeat and Its Role in Gene Expression

1994 • 37 citations

A Proliferative p53-Responsive Element Mediates Tumor Necrosis Factor Alpha Induction of the Human Immunodeficiency Virus Type 1 Long Terminal Repeat

1995 • 36 citations

Alternative pathway for induction of human immunodeficiency virus gene expression: involvement of the general transcription machinery

1991 • 36 citations

Heat shock of HeLa cells inactivates a nuclear protein phosphatase specific for dephosphorylation of the C-terminal domain of RNA polymerase II

1999 • 34 citations

Characterization of the Epitope Recognized by a Monoclonal Antibody Directed against the Largest Subunit ofDrosophilaRNA Polymerase II

1995 • 32 citations

The kinetics of HIV-1 long terminal repeat transcriptional activation resemble those of hsp70 promoter in heat-shock treated HeLa cells

1994 • 27 citations

On the use of α‐amanitin as a transcriptional blocking agent in mouse embryos: A cautionary note

1985 • 23 citations

Synergistic activation of simian immunodeficiency virus and human immunodeficiency virus type 1 transcription by retinoic acid and phorbol ester through an NF-kappa B-independent mechanism

1994 • 18 citations

Inducible transcriptional activation of the human immunodeficiency virus long terminal repeat by protein kinase inhibitors.

1993 • 12 citations

Phosphorylation of RNA polymerase II C-terminal domain (CTD): a new control for heat shock gene expression?

1998 • 10 citations

Effect of the Position of TAR on Transcriptional Activation by HIV-1 Tatin Vivo

1996 • 4 citations