The Human Immunodeficiency Virus Transactivator Tat Interacts with the RNA Polymerase II Holoenzyme

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

A multiprotein mediator of transcriptional activation and its interaction with the C-terminal repeat domain of RNA polymerase II

1994 • 1,064 citations

Relationship between cell shape and type of collagen synthesised as chondrocytes lose their cartilage phenotype in culture

1977 • 1,054 citations

Anti-termination of transcription within the long terminal repeat of HIV-1 by tat gene product

1987 • 902 citations

Complementation cloning of an MHC class II transactivator mutated in hereditary MHC class II deficiency (or bare lymphocyte syndrome)

1993 • 828 citations

CONTROL OF RNA INITIATION AND ELONGATION AT THE HIV-1 PROMOTER

1994 • 613 citations

HIV-1 Tat protein increases transcriptional initiation and stabilizes elongation

1989 • 577 citations

Dual role of TFIIH in DNA excision repair and in transcription by RNA polymerase II

1994 • 473 citations

COMMON THEMES IN ASSEMBLY AND FUNCTION OF EUKARYOTIC TRANSCRIPTION COMPLEXES

1995 • 434 citations

A kinase–cyclin pair in the RNA polymerase II holoenzyme

1995 • 418 citations

Cloning of an Intrinsic Human TFIID Subunit That Interacts with Multiple Transcriptional Activators

1995 • 385 citations

RNA Polymerase II Holoenzyme Contains SWI/SNF Regulators Involved in Chromatin Remodeling

1996 • 364 citations

The role of Tat in the human immunodeficiency virus life cycle indicates a primary effect on transcriptional elongation.

1991 • 360 citations

A human RNA polymerase II complex associated with SRB and DNA-repair proteins

1996 • 341 citations

Lentivirus Tat proteins specifically associate with a cellular protein kinase, TAK, that hyperphosphorylates the carboxyl-terminal domain of the large subunit of RNA polymerase II: candidate for a Tat cofactor

1995 • 338 citations

HIV-1 nef leads to inhibition or activation of T cells depending on its intracellular localization

1994 • 305 citations

Factors Involved in Specific Transcription by Mammalian RNA Polymerase II

1989 • 304 citations

The RNA polymerase II holoenzyme and its implications for gene regulation

1995 • 297 citations

HIV-1 Tat protein promotes formation of more-processive elongation complexes.

1991 • 295 citations

Three Functional Classes of Transcriptional Activation Domains

1996 • 267 citations

Contact with a component of the polymerase II holoenzyme suffices for gene activation

1995 • 262 citations

Multiple functional domains of Tat, thetrans-activator of HIV-1, defined by mutational analysis

1989 • 251 citations

Direct interaction of human TFIID with the HIV-1 transactivator Tat

1994 • 251 citations

A cDNA for a Protein That Interacts with the Human Immunodeficiency Virus Tat Transactivator

1990 • 234 citations

Factors involved in specific transcription by mammalian RNA polymerase II. Identification and characterization of factor IIH.

1992 • 230 citations

In vitro and in vivo binding of human immunodeficiency virus type 1 Tat protein and Sp1 transcription factor

1993 • 218 citations

The HIV-1 Tat protein activates transcription from an upstream DNA-binding site: implications for Tat function.

1991 • 217 citations

Transcriptional antitermination

1993 • 216 citations

HIV-1 Tat acts as a processivity factor in vitro in conjunction with cellular elongation factors.

1992 • 195 citations

A mammalian RNA polymerase II holoenzyme containing all components required for promoter-specific transcription initiation

1995 • 194 citations

Does HIV-1 Tat induce a change in viral initiation rights?

1993 • 166 citations

Human cyclin-dependent kinase-activating kinase exists in three distinct complexes.

1996 • 164 citations

A mammalian SRB protein associated with an RNA polymerase II holoenzyme

1996 • 144 citations

Tat-SF1: Cofactor for Stimulation of Transcriptional Elongation by HIV-1 Tat

1996 • 141 citations

tat regulates binding of the human immunodeficiency virus trans-activating region RNA loop-binding protein TRP-185.

1991 • 139 citations

Two distinct nuclear transcription factors recognize loop and bulge residues of the HIV-1 TAR RNA hairpin.

1991 • 137 citations

The human immunodeficiency virus Tat proteins specifically associate with TAK in vivo and require the carboxyl-terminal domain of RNA polymerase II for function

1996 • 129 citations

Gene activation by recruitment of the RNA polymerase II holoenzyme.

1996 • 123 citations

SSNGenes That Affect Transcriptional Repression inSaccharomyces cerevisiaeEncode SIN4, ROX3, and SRB Proteins Associated with RNA Polymerase II

1996 • 117 citations

Human Chromosome 12 Is Required for Elevated HIV-1 Expression in Human-Hamster Hybrid Cells

1989 • 109 citations

Genetic analysis of the cofactor requirement for human immunodeficiency virus type 1 Tat function

1993 • 107 citations

Trans-activation by human immunodeficiency virus Tat protein requires the C-terminal domain of RNA polymerase II.

1996 • 91 citations

Human immunodeficiency virus type-1 Tat is an integral component of the activated transcription-elongation complex.

1996 • 86 citations

The human immunodeficiency virus type 1 long terminal repeat specifies two different transcription complexes, only one of which is regulated by Tat

1993 • 85 citations

Human chromosome 12 is required for optimal interactions between Tat and TAR of human immunodeficiency virus type 1 in rodent cells

1992 • 81 citations

Molecular cloning and characterization of a cellular protein that interacts with the human immunodeficiency virus type 1 Tat transactivator and encodes a strong transcriptional activation domain

1995 • 81 citations

The mammalian analogue of the yeast PRP8 splicing protein is present in the U4/5/6 small nuclear ribonucleoprotein particle and the spliceosome.

1989 • 74 citations

Inhibition of human immunodeficiency virus type 1 Tat activity by coexpression of heterologous trans activators

1992 • 73 citations

Human immunodeficiency virus type 1 and 2 Tat proteins specifically interact with RNA polymerase II.

1996 • 62 citations

Isolation of a cellular protein that binds to the human immunodeficiency virus Tat protein and can potentiate transactivation of the viral promoter.

1991 • 59 citations

Interaction of human immunodeficiency virus type 1 Tat with a unique site of TFIID inhibits negative cofactor Dr1 and stabilizes the TFIID-TFIIA complex

1996 • 37 citations

Effects of human chromosome 12 on interactions between Tat and TAR of human immunodeficiency virus type 1

1994 • 37 citations

TAR loop-dependent human immunodeficiency virus trans activation requires factors encoded on human chromosome 12

1993 • 28 citations

Human Chromosome-Dependent and -Independent Pathways for HIV-2 Trans-Activation

1991 • 10 citations