Regulation of Carboxyl-terminal Domain Phosphatase by HIV-1 Tat Protein

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

A Novel CDK9-Associated C-Type Cyclin Interacts Directly with HIV-1 Tat and Mediates Its High-Affinity, Loop-Specific Binding to TAR RNA

1998 • 1,213 citations

Transcription elongation factor P-TEFb is required for HIV-1 Tat transactivation in vitro

1997 • 692 citations

Control of RNA Polymerase II Elongation Potential by a Novel Carboxyl-terminal Domain Kinase

1996 • 645 citations

CONTROL OF RNA INITIATION AND ELONGATION AT THE HIV-1 PROMOTER

1994 • 613 citations

HIV-1 Tat protein increases transcriptional initiation and stabilizes elongation

1989 • 577 citations

P-TEFb kinase is required for HIV Tat transcriptional activation in vivo and in vitro

1997 • 539 citations

Identification of multiple cyclin subunits of human P-TEFb

1998 • 512 citations

Reversible Phosphorylation of the C-terminal Domain of RNA Polymerase II

1996 • 498 citations

Phosphorylation of RNA polymerase II C-terminal domain and transcriptional elongation

1994 • 325 citations

The nonphosphorylated form of RNA polymerase II preferentially associates with the preinitiation complex.

1991 • 319 citations

HIV-1 Tat protein promotes formation of more-processive elongation complexes.

1991 • 295 citations

Messenger RNA synthesis in mammalian cells is catalyzed by the phosphorylated form of RNA polymerase II.

1987 • 288 citations

Enhanced processivity of RNA polymerase II triggered by Tat-induced phosphorylation of its carboxy-terminal domain

1996 • 255 citations

Trans-activation by HIV-1 Tat via a heterologous RNA binding protein

1990 • 236 citations

Purification using polyethylenimine precipitation and low molecular weight subunit analyses of calf thymus and wheat germ DNA-dependent RNA polymerase II

1977 • 222 citations

The HIV-1 Tat protein activates transcription from an upstream DNA-binding site: implications for Tat function.

1991 • 217 citations

Elongation factor-dependent transcript shortening by template-engaged RNA polymerase II.

1992 • 197 citations

HIV-1 Tat acts as a processivity factor in vitro in conjunction with cellular elongation factors.

1992 • 195 citations

Phosphorylation of RNA polymerase IIA occurs subsequent to interaction with the promoter and before the initiation of transcription.

1990 • 178 citations

Locus-specific variation in phosphorylation state of RNA polymerase II in vivo: correlations with gene activity and transcript processing.

1993 • 175 citations

TAK, an HIV Tat-associated kinase, is a member of the cyclin-dependent family of protein kinases and is induced by activation of peripheral blood lymphocytes and differentiation of promonocytic cell lines

1997 • 172 citations

Identification of a Cyclin Subunit Required for the Function ofDrosophila P-TEFb

1998 • 171 citations

An essential component of a C-terminal domain phosphatase that interacts with transcription factor IIF in Saccharomyces cerevisiae

1997 • 145 citations

FCP1, the RAP74-Interacting Subunit of a Human Protein Phosphatase That Dephosphorylates the Carboxyl-terminal Domain of RNA Polymerase IIO

1998 • 144 citations

Purification and characterization of a phosphatase from HeLa cells which dephosphorylates the C-terminal domain of RNA polymerase II

1994 • 137 citations

The human immunodeficiency virus Tat proteins specifically associate with TAK in vivo and require the carboxyl-terminal domain of RNA polymerase II for function

1996 • 129 citations

The interaction of RNA polymerase II with the adenovirus-2 major late promoter is precluded by phosphorylation of the C-terminal domain of subunit IIa.

1992 • 128 citations

Novel mechanism and factor for regulation by HIV-1 Tat.

1995 • 128 citations

Sp1-dependent activation of a synthetic promoter by human immunodeficiency virus type 1 Tat protein.

1991 • 124 citations

The Activity of COOH-terminal Domain Phosphatase Is Regulated by a Docking Site on RNA Polymerase II and by the General Transcription Factors IIF and IIB

1995 • 121 citations

Requirements for RNA Polymerase II Carboxyl-terminal Domain for Activated Transcription of Human Retroviruses Human T-Cell Lymphotropic Virus I and HIV-1

1996 • 105 citations

The Role of Multisite Phosphorylation in the Regulation of RNA Polymerase II Activity

1994 • 100 citations

Trans-activation by human immunodeficiency virus Tat protein requires the C-terminal domain of RNA polymerase II.

1996 • 91 citations

SII-facilitated transcript cleavage in RNA polymerase II complexes stalled early after initiation occurs in primarily dinucleotide increments

1993 • 83 citations

RNA polymerases IIA and IIO have distinct roles during transcription from the TATA-less murine dihydrofolate reductase promoter.

1993 • 81 citations

An RNA polymerase II transcription system from rat liver. Purification of an essential component.

1987 • 81 citations

Purification and Characterization of an RNA Polymerase II Phosphatase from Yeast

1996 • 76 citations

Partial purification and characterization of two distinct protein kinases that differentially phosphorylate the carboxyl-terminal domain of RNA polymerase subunit IIa.

1993 • 75 citations

Purified yeast RNA polymerase II reads through intrinsic blocks to elongation in response to the yeast TFIIS analogue, P37.

1994 • 56 citations

Importance of Codon Preference for Production of Human RAP74 and Reconstitution of the RAP30/74 Complex

1994 • 41 citations

Exon2 of HIV-2 Tat Contributes to transactivation of the HIV-2 LTR by increasing binding affinity to HIV-2 TAR RNA

1994 • 19 citations