Potential role of calcineurin for brain ischemia and traumatic injury

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

A synaptic model of memory: long-term potentiation in the hippocampus

1993 • 11,303 citations

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

Cell Death: The Significance of Apoptosis

1980 • 7,281 citations

Glutamate neurotoxicity and diseases of the nervous system

1988 • 7,257 citations

Long‐lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path

1973 • 7,118 citations

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

1980 • 4,591 citations

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

1991 • 4,043 citations

Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.

1990 • 3,304 citations

Protein kinases and phosphatases: The Yin and Yang of protein phosphorylation and signaling

1995 • 2,907 citations

Delayed neuronal death in the gerbil hippocampus following ischemia

1982 • 2,856 citations

Temporal profile of neuronal damage in a model of transient forebrain ischemia

1982 • 2,695 citations

Excitatory Amino Acids as a Final Common Pathway for Neurologic Disorders

1994 • 2,668 citations

Molecular Diversity of Glutamate Receptors and Implications for Brain Function

1992 • 2,535 citations

A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds

1993 • 2,423 citations

NITRIC OXIDE: A Physiologic Messenger Molecule

1994 • 2,299 citations

Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase.

1994 • 2,216 citations

The Role of Glutamate Neurotoxicity in Hypoxic-Ischemic Neuronal Death

1990 • 2,204 citations

Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures.

1991 • 2,173 citations

The mechanism of action of cyclosporin A and FK506

1992 • 2,127 citations

Small Differences in Intraischemic Brain Temperature Critically Determine the Extent of Ischemic Neuronal Injury

1987 • 1,821 citations

Brain Lesions, Obesity, and Other Disturbances in Mice Treated with Monosodium Glutamate

1969 • 1,802 citations

Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation

1992 • 1,634 citations

Programmed cell death involved in the schizolysigenous formation of the secretory cavity in Citrus sinensis L. (Osbeck)

2010 • 1,629 citations

Effects of Cerebral Ischemia in Mice Deficient in Neuronal Nitric Oxide Synthase

1994 • 1,578 citations

The Role of Excitatory Amino Acids and NMDA Receptors in Traumatic Brain Injury

1989 • 1,505 citations

Diffuse axonal injury and traumatic coma in the primate

1982 • 1,494 citations

Ca2 ⁺ Permeability of KA-AMPA—Gated Glutamate Receptor Channels Depends on Subunit Composition

1991 • 1,458 citations

Formation of nitric oxide from L-arginine in the central nervous system: a transduction mechanism for stimulation of the soluble guanylate cyclase.

1989 • 1,443 citations

Effect of anoxia on ion distribution in the brain

1985 • 1,341 citations

Primary structure and functional characterization of a high-affinity glutamate transporter

1992 • 1,319 citations

Treatment of Traumatic Brain Injury with Moderate Hypothermia

1997 • 1,308 citations

Calcium Fluxes, Calcium Antagonists, and Calcium-Related Pathology in Brain Ischemia, Hypoglycemia, and Spreading Depression: A Unifying Hypothesis

1989 • 1,237 citations

Cloning and expression of a rat brain L-glutamate transporter

1992 • 1,230 citations

NMDA-dependent superoxide production and neurotoxicity

1993 • 1,188 citations

Structure, expression, and functional analysis of a Na(+)-dependent glutamate/aspartate transporter from rat brain.

1992 • 1,185 citations

Synapsin I (protein I), a nerve terminal-specific phosphoprotein. III. Its association with synaptic vesicles studied in a highly purified synaptic vesicle preparation.

1983 • 1,162 citations

Primary structure and expression from complementary DNA of skeletal muscle ryanodine receptor

1989 • 1,132 citations

A controlled cortical impact model of traumatic brain injury in the rat

1991 • 1,123 citations

A mechanism for the Hebb and the anti-Hebb processes underlying learning and memory.

1989 • 1,114 citations

Effect of mild hypothermia on ischemia-induced release of neurotransmitters and free fatty acids in rat brain.

1989 • 1,110 citations

CREB Phosphorylation and Dephosphorylation: A Ca2+- and Stimulus Duration–Dependent Switch for Hippocampal Gene Expression

1996 • 1,109 citations

‘Ischemic tolerance’ phenomenon found in the brain

1990 • 1,098 citations

Classes of Calcium Channels in Vertebrate Cells

1989 • 1,082 citations

Massive increases in extracellular potassium and the indiscriminate release of glutamate following concussive brain injury

1990 • 1,080 citations

Involvement of a calcineurin/ inhibitor-1 phosphatase cascade in hippocampal long-term depression

1994 • 1,063 citations

Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A

1991 • 1,054 citations

Gases as biological messengers: nitric oxide and carbon monoxide in the brain

1994 • 1,052 citations

Role of Oxidants in Ischemic Brain Damage

1996 • 1,037 citations

A fluid percussion model of experimental brain injury in the rat

1987 • 1,031 citations

Microglial-produced nitric oxide and reactive nitrogen oxides mediate neuronal cell death

1992 • 939 citations

Diffuse axonal injury due to nonmissile head injury in humans: An analysis of 45 cases

1982 • 930 citations

FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin

1992 • 865 citations

Nitric oxide synthase: Aspects concerning structure and catalysis

1994 • 865 citations

A novel neuronal messenger molecule in brain: The free radical, nitric oxide

1992 • 837 citations

X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex

1995 • 821 citations

Stabilization of calcium release channel (ryanodine receptor) function by FK506-binding protein

1994 • 818 citations

The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun

1993 • 769 citations

Nuclear Export of NF-ATc Enhanced by Glycogen Synthase Kinase-3

1997 • 754 citations

Crystal structures of human calcineurin and the human FKBP12–FK506–calcineurin complex

1995 • 749 citations

Polymorphonuclear leukocytes occlude capillaries following middle cerebral artery occlusion and reperfusion in baboons.

1991 • 741 citations

MARCKS is an actin filament crosslinking protein regulated by protein kinase C and calcium–calmodulin

1992 • 728 citations

Calcineurin: a calcium- and calmodulin-binding protein of the nervous system.

1979 • 724 citations

Delayed hippocampal damage in humans following cardiorespiratory arrest

1987 • 710 citations

Synaptic plasticity in the hippocampus: LTP and LTD

1994 • 653 citations

DARPP-32, a dopamine- and adenosine 3':5'-monophosphate-regulated phosphoprotein enriched in dopamine-innervated brain regions. III. Immunocytochemical localization

1984 • 652 citations

Protein Phosphatases: Properties and Role in Cellular Regulation

1983 • 645 citations

Intraterminal injection of synapsin I or calcium/calmodulin-dependent protein kinase II alters neurotransmitter release at the squid giant synapse.

1985 • 636 citations

Serine/threonine protein phosphatases

1995 • 635 citations

Nitric oxide synthase regulatory sites. Phosphorylation by cyclic AMP-dependent protein kinase, protein kinase C, and calcium/calmodulin protein kinase; identification of flavin and calmodulin binding sites.

1992 • 621 citations

Association of Protein Kinase A and Protein Phosphatase 2B with a Common Anchoring Protein

1995 • 615 citations

DARPP-32, a dopamine-regulated neuronal phosphoprotein, is a potent inhibitor of protein phosphatase-1

1984 • 610 citations

Ischemia-induced neuronal apoptosis

1996 • 600 citations

Attenuation of focal cerebral ischemic injury in transgenic mice overexpressing CuZn superoxide dismutase.

1991 • 591 citations

Induced Tolerance to Ischemia in Gerbil Hippocampal Neurons

1991 • 584 citations

Human copper-zinc superoxide dismutase transgenic mice are highly resistant to reperfusion injury after focal cerebral ischemia.

1994 • 571 citations

Mitogen activated protein (MAP) kinase transforms tau protein into an Alzheimer-like state.

1992 • 563 citations

Inhibition of T cell signaling by immunophilin-ligand complexes correlates with loss of calcineurin phosphatase activity

1992 • 561 citations

The GTPase dynamin binds to and is activated by a subset of SH3 domains

1993 • 557 citations

Coordination of Three Signaling Enzymes by AKAP79, a Mammalian Scaffold Protein

1996 • 557 citations

Immunosuppressant FK506 enhances phosphorylation of nitric oxide synthase and protects against glutamate neurotoxicity.

1993 • 543 citations

Synapsin I (Protein I), a nerve terminal-specific phosphoprotein. II. Its specific association with synaptic vesicles demonstrated by immunocytochemistry in agarose-embedded synaptosomes.

1983 • 535 citations

Calcium and Ischemic Injury

1986 • 529 citations

Growth-associated protein, GAP-43, a polypeptide that is induced when neurons extend axons, is a component of growth cones and corresponds to pp46, a major polypeptide of a subcellular fraction enriched in growth cones.

1986 • 526 citations

FK506 binding protein associated with the calcium release channel (ryanodine receptor).

1992 • 525 citations

The kinetics of synaptic vesicle recycling measured at single presynaptic boutons

1993 • 523 citations

A Protein Induced During Nerve Growth (GAP-43) is a Major Component of Growth-Cone Membranes

1986 • 505 citations

Ischaemic brain damage is still common in fatal non-missile head injury.

1989 • 499 citations

Influx of leukocytes and platelets in an evolving brain infarct (Wistar rat).

1994 • 491 citations

Role of kinases and the phosphatase calcineurin in the nuclear shuttling of transcription factor NF-AT4

1996 • 487 citations

Calcineurin associated with the inositol 1,4,5-trisphosphate receptor-FKBP12 complex modulates Ca2+ flux

1995 • 484 citations

Regulation of NMDA channel function by endogenous Ca2+-dependent phosphatase

1994 • 483 citations

Intraischemic but Not Postischemic Brain Hypothermia Protects Chronically following Global Forebrain Ischemia in Rats

1993 • 481 citations

Discovery of A Ca²⁺‐and calmodulin‐dependent protein phosphatase

1982 • 476 citations

Polymorphonuclear leukocyte accumulation in brain regions with low blood flow during the early postischemic period.

1986 • 474 citations

Purification of cyclic 3',5'-nucleotide phosphodiesterase inhibitory protein by affinity chromatography on activator protein coupled to sepharose

1978 • 463 citations

Immunophilins mediate the neuroprotective effects of FK506 in focal cerebral ischaemia

1994 • 462 citations

Characterization of antigen receptor response elements within the interleukin-2 enhancer.

1988 • 451 citations

Germinal center cells express bcl‐2 protein after activation by signals which prevent their entry into apoptosis

1991 • 446 citations

Separation and Characterization of Two Phosphorylase Phosphatase Inhibitors from Rabbit Skeletal Muscle

1976 • 439 citations

Identification of dynamin, a novel mechanochemical enzyme that mediates interactions between microtubules

1989 • 436 citations

Potentiation of NMDA receptor currents by arachidonic acid

1992 • 428 citations

Superoxide production in experimental brain injury

1986 • 420 citations

Development of neuronal polarity: GAP-43 distinguishes axonal from dendritic growth cones

1988 • 413 citations

Synapsin I bundles F-actin in a phosphorylation-dependent manner

1987 • 409 citations

An enzymatic mechanism for calcium current inactivation in dialysed Helix neurones.

1986 • 409 citations

Biochemical-physiology correlations in studies of the γ-aminobutyric acid system

1968 • 408 citations

The ryanodine receptor/Ca2+ release channel

1993 • 404 citations

Synaptic Desensitization of NMDA Receptors by Calcineurin

1995 • 404 citations

n-Tetradecanoyl is the NH2-terminal blocking group of the catalytic subunit of cyclic AMP-dependent protein kinase from bovine cardiac muscle.

1982 • 395 citations

Depolarization-induced phosphorylation of specific proteins, mediated by calcium ion influx, in rat brain synaptosomes.

1977 • 393 citations

Brain Cortical Fatty Acids and Phospholipids During and Following Complete and Severe Incomplete Ischemia

1982 • 387 citations

Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins

1995 • 383 citations

Persistent inhibition of protein synthesis precedes delayed neuronal death in postischemic gerbil hippocampus

1986 • 380 citations

Fos: An immediate‐early transcription factor in neurons

1995 • 373 citations

Characterization of Ca2+/calmodulin-dependent protein kinase IV. Role in transcriptional regulation.

1994 • 370 citations

The Immunophilin FKBP12 Functions as a Common Inhibitor of the TGFβ Family Type I Receptors

1996 • 370 citations

Inhibition of polymorphonuclear leukocyte adherence suppresses no-reflow after focal cerebral ischemia in baboons.

1992 • 368 citations

Suppression of signalling through transcription factor NF-AT by interactions between calcineurin and Bcl-2

1997 • 368 citations

Inhibition of proteolysis protects hippocampal neurons from ischemia.

1991 • 363 citations

Activation of NMDA receptors induces dephosphorylation of DARPP-32 in rat striatal slices

1990 • 356 citations

The calcium release channel of sarcoplasmic reticulum is modulated by FK-506-binding protein. Dissociation and reconstitution of FKBP-12 to the calcium release channel of skeletal muscle sarcoplasmic reticulum.

1993 • 353 citations

Postischemic administration of an anti-Mac-1 antibody reduces ischemic cell damage after transient middle cerebral artery occlusion in rats.

1994 • 347 citations

Immunosuppressive drugs prevent a rapid dephosphorylation of transcription factor NFAT1 in stimulated immune cells.

1995 • 347 citations

A dopamine- and cyclic AMP-regulated phosphoprotein enriched in dopamine-innervated brain regions

1983 • 342 citations

High brain densities of the immunophilin FKBP colocalized with calcineurin

1992 • 340 citations

Calcineurin acts in synergy with PMA to inactivate I kappa B/MAD3, an inhibitor of NF-kappa B.

1994 • 334 citations

Amelioration of delayed neuronal death in the hippocampus by nerve growth factor

1991 • 333 citations

Expression of the inducible form of nitric oxide synthase by reactive astrocytes after transient global ischemia

1994 • 327 citations

Kappa B-Specific DNA Binding Proteins: Role in the Regulation of Human Interleukin-2 Gene Expression

1989 • 327 citations

Molecular cloning, characterization, and expression of a cDNA encoding the "80- to 87-kDa" myristoylated alanine-rich C kinase substrate: a major cellular substrate for protein kinase C.

1989 • 318 citations

Regional Energy Balance in Rat Brain After Transient Forebrain Ischemia

1983 • 315 citations

Characterization of synapsin I binding to small synaptic vesicles.

1986 • 304 citations

Microtubule-associated protein 2 as a sensitive marker for cerebral ischemic damage—Immunohistochemical investigation of dendritic damage

1989 • 303 citations

Yeast has homologs (CNA1 and CNA2 gene products) of mammalian calcineurin, a calmodulin-regulated phosphoprotein phosphatase.

1991 • 297 citations

The Regulation of Glycogen Metaabolism

1978 • 297 citations

Two calcium/calmodulin-dependent protein kinases, which are highly concentrated in brain, phosphorylate protein I at distinct sites.

1981 • 296 citations

Immunophilin FK506 binding protein associated with inositol 1,4,5-trisphosphate receptor modulates calcium flux.

1995 • 288 citations

Ischemic Delayed Neuronal Death

1995 • 285 citations

Immunosuppressant FK506 promotes neurite outgrowth in cultures of PC12 cells and sensory ganglia.

1994 • 284 citations

Multiple phosphorylation sites in protein I and their differential regulation by cyclic AMP and calcium.

1979 • 284 citations

Protective effects of liposome‐entrapped superoxide dismutase on posttraumatic brain edema

1987 • 283 citations

Neurobiology of Nitric Oxide

1996 • 281 citations

β-Adrenergic Regulation of Synaptic NMDA Receptors by cAMP-Dependent Protein Kinase

1996 • 280 citations

Animate Models of Human Head Injury

1994 • 278 citations

Increased vulnerability of the midly traumatized rat brain to cerebral ischemia: the use of controlled secondary ischemia as a research tool to identify common or different mechanisms contributing to mechanical and ischemic brain injury

1989 • 277 citations

Induction of DNA Fragmentation After 10 to 120 Minutes of Focal Cerebral Ischemia in Rats

1995 • 276 citations

Regional Changes in Interstitial K⁺and Ca²⁺Levels following Cortical Compression Contusion Trauma in Rats

1993 • 275 citations

Purification and characterization of a brain-specific protein kinase C substrate, neurogranin (p17). Identification of a consensus amino acid sequence between neurogranin and neuromodulin (GAP43) that corresponds to the protein kinase C phosphorylation site and the calmodulin-binding domain.

1991 • 274 citations

Dynamin GTPase regulated by protein kinase C phosphorylation in nerve terminals

1993 • 272 citations

Mechanism of Arachidonic Acid Liberation During Ischemia in Gerbil Cerebral Cortex

1987 • 271 citations

Superoxide dismutase protects calcineurin from inactivation

1996 • 270 citations

Ultrastructural changes in the hippocampal CA1 region following transient cerebral ischemia: evidence against programmed cell death

1992 • 270 citations

Afferent and Efferent Relationships of the Basal Ganglia

1984 • 270 citations

Identification of an autoinhibitory domain in calcineurin.

1990 • 268 citations

Inhibition of noradrenaline release by antibodies to B-50 (GAP-43)

1989 • 267 citations

Liposome-entrapped superoxide dismutase reduces cerebral infarction in cerebral ischemia in rats.

1990 • 266 citations

Phosphorylation of tau proteins to a state like that in Alzheimer's brain is catalyzed by a calcium/calmodulin-dependent kinase and modulated by phospholipids.

1987 • 264 citations

Neurogranin: immunocytochemical localization of a brain-specific protein kinase C substrate

1990 • 263 citations

Identification and characterization of the calmodulin-binding domain of neuromodulin, a neurospecific calmodulin-binding protein.

1988 • 262 citations

Calcineurin functions in Ca(2+)-activated cell death in mammalian cells.

1995 • 260 citations

Ultrastructural and light microscopic evidence of apoptosis after middle cerebral artery occlusion in the rat.

1995 • 258 citations

Modulator binding protein. Bovine brain protein exhibiting the Ca2+-dependent association with the protein modulator of cyclic nucleotide phosphodiesterase.

1977 • 252 citations

Free radicals in central nervous system ischemia.

1990 • 251 citations

Administration of Excitatory Amino Acid Antagonists via Microdialysis Attenuates the Increase in Glucose Utilization Seen following Concussive Brain Injury

1992 • 249 citations

Expression of growth-associated protein B-50 (GAP43) in dorsal root ganglia and sciatic nerve during regenerative sprouting

1989 • 249 citations

Immunophilins in protein folding and immunosuppression ¹

1994 • 247 citations

Identification of cis-acting regulatory elements controlling interleukin-4 gene expression in T cells: roles for NF-Y and NF-ATc.

1993 • 245 citations

Inhibition of microtubule assembly by phosphorylation of microtubule-associated proteins

1980 • 245 citations

Regulatory subunit (CNB1 gene product) of yeast Ca2+/calmodulin-dependent phosphoprotein phosphatases is required for adaptation to pheromone.

1992 • 244 citations

Phosphorylation-regulated calmodulin binding to a prominent cellular substrate for protein kinase C

1989 • 241 citations

Review Lecture: Protein phosphorylation and hormone action

1988 • 237 citations

Calcineurin and mitochondrial function in glutamate‐induced neuronal cell death

1996 • 234 citations

Anti‐CD11b monoclonal antibody reduces ischemic cell damage after transient focal cerebral ischemia in rat

1994 • 231 citations

Regional Protein Synthesis in Rat Brain Following Acute Hemispheric Ischemia

1980 • 231 citations

Global Ischemia Activates Nuclear Factor-κB in Forebrain Neurons of Rats

1997 • 219 citations

Selective sparing of NADPH‐diaphorase–somatostatin–neuropeptide Y neurons in ischemic gerbil striatum

1990 • 218 citations

Stimulus-dependent myristoylation of a major substrate for protein kinase C

1988 • 216 citations

Free radical generation during brief period of cerebral ischemia may trigger delayed neuronal death

1990 • 216 citations

Calcineurin Inhibition of Dynamin I GTPase Activity Coupled to Nerve Terminal Depolarization

1994 • 215 citations

Neuroprotective Actions of FK506 in Experimental Stroke:In VivoEvidence against an Antiexcitotoxic Mechanism

1997 • 214 citations

Dynamin is a GTPase stimulated to high levels of activity by microtubules

1992 • 211 citations

CONCENTRATIONS OF ENERGY METABOLITES AND CYCLIC NUCLEOTIDES DURING AND AFTER BILATERAL ISCHEMIA IN THE GERBIL CEREBRAL CORTEX

1977 • 210 citations

DARPP-32, a dopamine- and adenosine 3':5'-monophosphate-regulated phosphoprotein enriched in dopamine-innervated brain regions. II. Purification and characterization of the phosphoprotein from bovine caudate nucleus

1984 • 209 citations

Ischemia triggers NMDA receptor-linked cytoskeletal proteolysis in hippocampus

1989 • 209 citations

Neuronal (type I) nitric oxide synthase regulates nuclear factorκB activity and immunologic (type II) nitric oxide synthase expression

1997 • 202 citations

Glutamate, calcium, and free radicals as mediators of ischemic brain damage

1995 • 201 citations

The granulocyte-macrophage colony-stimulating factor/interleukin 3 locus is regulated by an inducible cyclosporin A-sensitive enhancer.

1993 • 201 citations

Enhancement of hippocampal excitatory synaptic transmission by platelet-activating factor

1992 • 201 citations

Calmodulin-stimulated dephosphorylation of p-nitrophenyl phosphate and free phosphotyrosine by calcineurin.

1983 • 198 citations

Phosphorylation by cAMP-dependent protein kinase inhibits the degradation of tau by calpain.

1992 • 196 citations

Immunophilins and nervous system

1995 • 195 citations

Mammalian brain phosphoproteins as substrates for calcineurin.

1984 • 195 citations

Calcium channel regulation by calcineurin, a Ca2+-activated phosphatase in mammalian brain

1989 • 195 citations

High Sensitivity of Glutamate Uptake to Extracellular Free Arachidonic Acid Levels in Rat Cortical Synaptosomes and Astrocytes

1992 • 188 citations

Lactate accumulation following concussive brain injury: the role of ionic fluxes induced by excitatory amino acids

1995 • 187 citations

Dephosphorylation of cAMP-dependent protein kinase regulatory subunit (type II) by calmodulin-dependent protein phosphatase. Determinants of substrate specificity.

1986 • 187 citations

The Protein Phosphatases Involved in Cellular Regulation. 5. Purification and Properties of a Ca2+ /Calmodulin-Dependent Protein Phosphatase (2B) from Rabbit Skeletal Muscle

1983 • 186 citations

Nerve growth cones isolated from fetal rat brain. III. Calcium- dependent protein phosphorylation

1985 • 185 citations

Ca²⁺, Calmodulin‐Dependent Regulation of Microtubule Formation via Phosphorylation of Microtubule‐Associated Protein 2, τ Factor, and Tubulin, and Comparison with the Cyclic AMP‐Dependent Phosphorylation

1985 • 183 citations

Ca²⁺– and Calmodulin‐Dependent Phosphorylation of Microtubule‐Associated Protein 2 and t Factor, and Inhibition of Microtubule Assembly

1983 • 180 citations

Inositol 1,4,5‐Trisphosphate Receptor‐Mediated Ca²⁺ Signaling in the Brain

1995 • 180 citations

Adenosine 3′,5-Monophosphatedependent Phosphorylation of a Specific Protein in Synaptic Membrane Fractions from Rat Cerebrum

1972 • 177 citations

Synapsin I: an actin-bundling protein under phosphorylation control.

1987 • 176 citations

The Complex Role of Nitric Oxide in the Pathophysiology of Focal Cerebral Ischemia

1994 • 176 citations

Platelet-activating factor (PAF) receptor in rat brain: PAF mobilizes intracellular Ca2+ in hippocampal neurons

1992 • 175 citations

Specific inhibition of calcineurin by type II synthetic pyrethroid insecticides

1992 • 175 citations

Phosphorylation of DARPP-32, a dopamine- and cAMP-regulated phosphoprotein, by casein kinase II

1989 • 175 citations

Changes in Brain Energy Metabolism and Protein Synthesis Following Transient Bilateral Ischemia in the Gerbil

1985 • 174 citations

Dephosphorylation of Microtubule‐Associated Protein 2, τ Factor, and Tubulin by Calcineurin

1985 • 173 citations

The distribution of calcineurin in rat brain by light and electron microscopic immunohistochemistry and enzyme-immunoassay

1986 • 172 citations

Cerebral Protein Synthesis and Ischemia

1985 • 170 citations

Phosphorylation and associated translocation of the 87-kDa protein, a major protein kinase C substrate, in isolated nerve terminals.

1989 • 169 citations

Activation of dynamin GTPase by acidic phospholipids and endogenous rat brain vesicles

1993 • 164 citations

Identification of the protein kinase C phosphorylation site in neuromodulin

1990 • 164 citations

Changes in extracellular potassium concentration in cortex and brain stem during the acute phase of experimental closed head injury

1981 • 163 citations

Cloning of human calcineurin A: evidence for two isozymes and identification of a polyproline structural domain.

1989 • 163 citations

The calmodulin-dependent activation and deactivation of the phosphoprotein phosphatase, calcineurin, and the effect of nucleotides, pyrophosphate, and divalent metal ions. Identification of calcineurin as a Zn and Fe metalloenzyme.

1984 • 160 citations

The function of dynamin in endocytosis

1995 • 159 citations

Asymmetric retraction of growth cone filopodia following focal inactivation of calcineurin

1995 • 158 citations

Dephosphorylation of Neuromodulin by Calcineurin

1989 • 157 citations

Apoptotic DNA fragmentation in the rat cerebral cortex induced by permanent middle cerebral artery occlusion

1995 • 156 citations

The structure of the B subunit of calcineurin

1984 • 156 citations

Extracellular Potassium Concentration in Juvenile and Adult Rat Brain Cortex during Anoxia

1977 • 156 citations

Concerted regulation of protein phosphorylation and dephosphorylation by calmodulin

1991 • 155 citations

Staurosporine, a Novel Protein Kinase C Inhibitor, Prevents Postischemic Neuronal Damage in the Gerbil and Rat

1990 • 154 citations

P-57 is a neural specific calmodulin-binding protein.

1985 • 152 citations

Inhibition by calmodulin of calcium/phospholipid-dependent protein phosphorylation.

1984 • 151 citations

Tyrosine Phosphorylation and Activation of Mitogen‐ Activated Protein Kinase in the Rat Brain Following Transient Cerebral Ischemia

1994 • 147 citations

Localization of the protein kinase C phosphorylation/calmodulin-binding substrate RC3 in dendritic spines of neostriatal neurons.

1992 • 147 citations

The role of neutrophils and platelets in a rabbit model of thromboembolic stroke.

1991 • 146 citations

A brain protein and its effect on the CA2+-and protein modulator-activated cyclic nucleotide phosphodiesterase

1976 • 144 citations

Nitric oxide and focal cerebral ischemia: multiplicity of actions and diverse outcome.

1994 • 144 citations

The immunophilins, FK506 binding protein and cyclophilin, are discretely localized in the brain: relationship to calcineurin

1994 • 141 citations

[¹⁴C]Leucine Incorporation into Brain Proteins in Gerbils After Transient Ischemia: Relationship to Selective Vulnerability of Hippocampus

1991 • 138 citations

Purification and characterization of an inhibitor protein of brain adenylate cyclase and cyclic nucleotide phosphodiesterase.

1979 • 137 citations

Microtubules and Src homology 3 domains stimulate the dynamin GTPase via its C-terminal domain.

1993 • 137 citations

Synapsin I is a microtubule-bundling protein

1986 • 137 citations

Postsynaptic Mechanisms for Bidirectional Control of MAP2 Phosphorylation by Glutamate Receptors

1996 • 136 citations

Direct Demonstration of NFATp Dephosphorylation and Nuclear Localization in Activated HT-2 Cells Using a Specific NFATp Polyclonal Antibody

1995 • 134 citations

Ischemia‐Induced Translocation of Ca²⁺/Calmodulin‐Dependent Protein Kinase II: Potential Role in Neuronal Damage

1992 • 134 citations

[22] Isolation and characterization of bovine brain calcineurin: A calmodulin-stimulated protein phosphatase

1983 • 133 citations

High levels of a heat-labile calmodulin-binding protein (CaM-BP80) in bovine neostriatum

1980 • 130 citations

Cloning and characterization of molecular isoforms of the catalytic subunit of calcineurin using nonisotopic methods.

1990 • 130 citations

Permeability of the Blood‐Brain Barrier to the Immunosuppressive Cyclic Peptide Cyclosporin A

1990 • 128 citations

Calcineurin-mediated protein dephosphorylation in brain nerve terminals regulates the release of glutamate.

1994 • 126 citations

Brain infarction is not reduced in SOD-1 transgenic mice after a permanent focal cerebral ischemia

1993 • 126 citations

Expression of the transcription factor NFATp in a neuronal cell line and in the murine nervous system.

1994 • 123 citations

Experimental head injury in the rat

1977 • 123 citations

Calcineurin is a calmodulin-dependent protein phosphatase

1982 • 121 citations

Phosphorylation and dephosphorylation of dihydropyridine-sensitive voltage-dependent Ca2+ channel in skeletal muscle membranes by cAMP- and Ca2+-dependent processes.

1986 • 120 citations

B-50 phosphorylation and polyphosphoinositide metabolism in nerve growth cone membranes

1988 • 119 citations

Phosphorylation of dynamin I and synaptic-vesicle recycling

1994 • 117 citations

Localization of the MARCKS (87 kDa) protein, a major specific substrate for protein kinase C, in rat brain

1990 • 116 citations

Regulation of the AKAP79-Protein Kinase C Interaction by Ca2+/Calmodulin

1997 • 116 citations

The Role of Brain-derived Neurotrophic Factor in Transient Forebrain Ischemia in the Rat Brain

1994 • 115 citations

Workshop on Animal Models of Traumatic Brain Injury

1994 • 114 citations

The multiple phosphorylation of the microtubule-associated protein MAP2 controls the MAP2: tubulin interaction

1984 • 112 citations

Postsynaptic Calcineurin Activity Downregulates Synaptic Transmission by Weakening Intracellular Ca²⁺Signaling Mechanisms in Hippocampal CA1 Neurons

1997 • 111 citations

Evidence for a Single Protein Kinase C‐Mediated Phosphorylation Site in Rat Brain Protein B‐50

1989 • 109 citations

Ischemic damage in the striatum of adult gerbils: Relative sparing of somatostatinergic and cholinergic interneurons contrasts with loss of efferent neurons

1990 • 108 citations

The complete primary structure of calcineurin A, a calmodulin binding protein homologous with protein phosphatases 1 and 2A

1989 • 108 citations

Energy metabolism in delayed neuronal death of CA1 neurons of the hippocampus following transient ischemia in the gerbil

1986 • 107 citations

Transgenic Mice and Knockout Mutants in the Study of Oxidative Stress in Brain Injury

1995 • 106 citations

Hypothermia Attenuates the Loss of Hippocampal Microtubule-Associated Protein 2 (MAP2) following Traumatic Brain Injury

1993 • 104 citations

Transcription of the interleukin 4 gene is regulated by multiple promoter elements.

1993 • 103 citations

Stress-induced inhibition of protein synthesis initiation: modulation of initiation factor 2 and guanine nucleotide exchange factor activities following transient cerebral ischemia in the rat

1993 • 102 citations

Regional Alterations of Protein Kinase C Activity Following Transient Cerebral Ischemia: Effects of Intraischemic Brain Temperature Modulation

1994 • 102 citations

Association of synapsin I with neuronal cytoskeleton. Identification in cytoskeletal preparations in vitro and immunocytochemical localization in brain of synapsin I.

1986 • 102 citations

Dynamin I is a Ca(2+)-sensitive phospholipid-binding protein with very high affinity for protein kinase C.

1994 • 101 citations

Transgenic approaches to cognition

1995 • 101 citations

An immunohistochemical study of copper/zinc superoxide dismutase and manganese superoxide dismutase in rat hippocampus after transient cerebral ischemia

1993 • 100 citations

Presynaptic modulation of cortical synaptic activity by calcineurin.

1995 • 99 citations

Cytoskeletal Changes in the Brains of Mice Lacking Calcineurin Aα

1997 • 97 citations

Leukocyte involvement in cerebral infarct generation after ischemia and reperfusion

1994 • 96 citations

Differential localization of calmodulin-dependent enzymes in rat brain: evidence for selective expression of cyclic nucleotide phosphodiesterase in specific neurons.

1987 • 96 citations

Dopamine- and cAMP-regulated phosphoprotein DARPP-32: phosphorylation of Ser-137 by casein kinase I inhibits dephosphorylation of Thr-34 by calcineurin.

1995 • 95 citations

Time Course of the Translocation and Inhibition of Protein kinase C During Complete Cerebral Ischemia in the Rat

1993 • 93 citations

Myristoylated and Nonmyristoylated Forms of a Protein Are Phosphorylated by Protein Kinase C

1989 • 89 citations

Casein kinase II preferentially phosphorylates human tau isoforms containing an amino-terminal insert. Identification of threonine 39 as the primary phosphate acceptor.

1994 • 89 citations

Evidence for a second isoform of the catalytic subunit of calmodulin-dependent protein phosphatase (calcineurin A)

1989 • 88 citations

Regulation of calcineurin by phosphorylation

1989 • 86 citations

Diminished Microtubule-Associated Protein 2 (MAP2) Immunoreactivity following Cortical Impact Brain Injury

1996 • 85 citations

REGULATION OF TRANSFORMING GROWTH FACTOR-β1 AND ITS RECEPTOR BY CYCLOSPORINE IN HUMAN T LYMPHOCYTES

1995 • 84 citations

Mononucleotide Metabolism in the Rat Brain After Transient Ischemia

1986 • 84 citations

Depolarisation‐Dependent Protein Phosphorylation in Rat Cortical Synaptosomes: Factors Determining the Magnitude of the Response

1983 • 83 citations

Induction of Copper-Zinc Superoxide Dismutase in Gerbil Hippocampus after Ischemia

1993 • 83 citations

Activation of brain calcineurin phosphatase towards nonprotein phosphoesters by Ca2+, calmodulin, and Mg2+.

1984 • 83 citations

The immunosuppressant FK506 ameliorates ischaemic damage in the rat brain

1996 • 83 citations

Activation of a calmodulin-dependent phosphatase by a calcium-dependent protease

1988 • 82 citations

Alterations in τ Immunostaining in the Rat Hippocampus following Transient Cerebral Ischemia

1994 • 82 citations

Effect of Brain Ischemia on Protein Kinase C

1992 • 82 citations

Activation of calcineurin by nickel ions

1983 • 82 citations

Role of Excitatory Amino Acid‐Mediated Ionic Fluxes in Traumatic Brain Injury

1995 • 82 citations

Tacrolimus (FK506) Ameliorates Skilled Motor Deficits Produced by Middle Cerebral Artery Occlusion in Rats

1996 • 81 citations

The Role of Excitatory Amino Acids in Severe Brain Trauma: Opportunities for Therapy: A Review

1995 • 81 citations

Modulation of the phosphorylation state of tau in situ: the roles of calcium and cyclic AMP

1995 • 78 citations

Experimental head injury in the rat

1977 • 78 citations

Changes in the concentrations of cerebral proteins following occlusion of the middle cerebral artery in rats.

1990 • 78 citations

Excitotoxic activation of the NMDA receptor results in inhibition of calcium/calmodulin kinase II activity in cultured hippocampal neurons

1995 • 77 citations

Phosphorylation of DARPP-32, a Dopamine- and cAMP-regulated Phosphoprotein, by Casein Kinase I in Vitro and in Vivo

1995 • 77 citations

Dephosphorylation of Protein Kinase C Substrates, Neurogranin, Neuromodulin, and MARCKS, by Calcineurin and Protein Phosphatases 1 and 2A

1995 • 76 citations

An immunosuppressant, FK506, protects hippocampal neurons from forebrain ischemia in the Mongolian gerbil

1996 • 75 citations

Relative sparing of GABAergic interneurons in the striatum of gerbils with ischemia-induced lesions

1992 • 74 citations

Brain damage in fatal non-missile head injury without high intracranial pressure.

1988 • 72 citations

Brain L-Glutamate Decarboxylase

1995 • 71 citations

Early recovery of protein synthesis following ischemia in hippocampal neurons with induced tolerance in the gerbil

1993 • 71 citations

Differential expression of calmodulin-binding proteins in B, T lymphocytes and thymocytes

1987 • 70 citations

An endogenous inhibitor protein of brain adenylate cyclase and cyclic nucleotide phosphodiesterase

1978 • 69 citations

Primary Structure of Parvalbumin from Rat Skeletal Muscle

1982 • 69 citations

Oxidative metabolic activity of cerebral cortex after fluid-percussion head injury in the cat

1981 • 68 citations

CONCERTED ROLE OF CALMODULIN AND CALCINEURIN IN CALCIUM REGULATION

1980 • 68 citations

Protective Effect of FK506 on Ischemia/Reperfusion-Induced Myocardial Damage in Canine Heart

1993 • 68 citations

Neuroprotective effect of FK506, an immunosuppressant, on transient global ischemia in gerbil

1996 • 67 citations

Hippocampal CA₃Lesion Prevents Postconcussive Metabolic Dysfunction in CA₁

1992 • 66 citations

Immunophilin Regulation of Neurotransmitter Release

1996 • 65 citations

SEQUENCES OF INTEREST: Molecular Cloning, Sequence, and Expression of a cDNA Encoding the Chicken Myristoylated Alanine-Rich C Kinase Substrate (MARCKS)

1989 • 65 citations

Regional and Temporal Alterations in Ca²⁺/Calmodulin‐Dependent Protein Kinase II and Calcineurin in the Hippocampus of Rat Brain After Transient Forebrain Ischemia

1992 • 65 citations

Ischemia‐Induced Loss of Brain Calcium/Calmodulin‐Dependent Protein Kinase II

1992 • 63 citations

Calcineurin-mediated dephosphorylation of the human placental membrane receptor for epidermal growth factor urogastrone

1985 • 61 citations

Inhibitory effect of cyclosporin A and FK506 on nitric oxide production by cultured macrophages. Evidence of a direct effect on nitric oxide synthase activity.

1995 • 61 citations

An immunohistochemical study of MAP2 and clathrin in gerbil hippocampus after cerebral ischemia

1991 • 61 citations

Molecular mechanisms of trauma-induced neuronal degeneration.

1993 • 61 citations

Nilvadipine attenuates ischemic degradation of gerbil brain cytoskeletal proteins.

1989 • 60 citations

Distribution of Protein Phosphatase Inhibitor‐1 in Brain and Peripheral Tissues of Various Species: Comparison with DARPP‐32

1992 • 60 citations

Ultrastructural investigation of the CA1 region of the hippocampus after transient cerebral ischemia in gerbils

1990 • 60 citations

Differential stimulation of protein kinase C activity by phorbol ester or calcium/phosphatidylserine in vitro and in intact synaptosomes.

1992 • 60 citations

Glutamate Neurotoxicity Is Independent of Calpain I Inhibition in Primary Cultures of Cerebellar Granule Cells

1991 • 59 citations

Rate of cerebral energy consumption in concussive head injury in the rat

1977 • 59 citations

Morphological characterization of the rat striatal neurons expressing calcineurin immunoreactivity

1987 • 59 citations

Calmodulin-dependent protein phosphatase: a developmental study

1983 • 58 citations

Chronic maintenance of presynaptic terminals in gliotic hippocampus following ischemia

1990 • 57 citations

Differential Phosphorylation of τ by Cyclic AMP‐Dependent Protein Kinase and Ca²⁺/Calmodulin‐Dependent Protein Kinase II: Metabolic and Functional Consequences

1992 • 57 citations

Decreased Protein Kinase C Activity During Cerebral Ischemia and After Reperfusion in the Adult Rat

1990 • 57 citations

Effect of immunosuppressant FK506 on ischemia-induced degeneration of hippocampal neurons in gerbils

1996 • 57 citations

Immunohistochemical Determination of Calcium—Calmodulin Binding Predicts Neuronal Damage after Global Ischemia

1989 • 56 citations

Recovery of protein synthesis in tolerance-induced hippocampal CA1 neurons after transient forebrain ischemia

1993 • 56 citations

The divalent cation dependence of bovine brain calmodulin-dependent phosphatase.

1985 • 56 citations

Partial structure and hormonal regulation of rabbit liver inhibitor-1; distribution of inhibitor-1 and inhibitor-2 in rabbit and rat tissues

1989 • 55 citations

Global Forebrain Ischemia Induces a Posttranslational Modification of Multifunctional Calcium‐ and Calmodulin‐Dependent Kinase II

1992 • 54 citations

Characterization of phosphotyrosyl-protein phosphatase activity associated with calcineurin

1984 • 54 citations

Isolation and Sequence of a cDNA Clone for Human Calcineurin B, the Ca²⁺-Binding Subunit of the Ca²⁺/Calmodulin-Stimulated Protein Phosphatase

1989 • 51 citations

Calcium Channel Antagonists in the Prevention of Neurotoxicity

1991 • 50 citations

Catalytic site of calmodulin-dependent protein phosphatase from bovine brain resides in subunit A.

1984 • 50 citations

Activation of bovine brain calmodulin-dependent protein phosphatase by limited trypsinization

1984 • 49 citations

Effects of pretreatment with sublethal ischemia on the extracellular glutamate concentrations during secondary ischemia in the gerbil hippocampus evaluated with intracerebral microdialysis

1992 • 49 citations

DARPP‐32 and Phosphatase Inhibitor‐1, Two Structurally Related Inhibitors of Protein Phosphatase‐1, Are Both Present in Striatonigral Neurons

1988 • 49 citations

Molecular cloning and characterization of the genes encoding the two subunits of Drosophila melanogaster calcineurin.

1992 • 49 citations

Glutamate‐Induced Loss of Ca²⁺/Calmodulin‐Dependent Protein Kinase II Activity in Cultured Rat Hippocampal Neurons

1995 • 48 citations

The Dendritic Peptide Neurogranin Can Regulate a Calmodulin‐Dependent Target

1995 • 48 citations

Phosphorylation of dynamin by ERK2 inhibits the dynamin‐microtubule interaction

1996 • 46 citations

Immunocytochemical localization of phosphatase inhibitor‐1 in rat brain

1991 • 45 citations

Inhibition of nitric oxide synthase protects against hypoxic neuronal injury

1992 • 45 citations

Characterization of bovine brain calmodulindependent protein phosphatase

1984 • 44 citations

Calmodulin-dependent protein phosphatases from microorganisms to man. A study in structural conservatism and biological diversity.

1993 • 43 citations

Protein Phosphorylation and Hormone Action

1976 • 43 citations

Tumor necrosis factor-α up-regulates Bcl-2 expression and decreases calcium-dependent apoptosis in human B cell lines

1995 • 42 citations

N-methyl-d-aspartate stimulates the dephosphorylation of the microtubule-associated protein 2 and potentiates excitatory synaptic pathways in the rat hippocampus

1993 • 42 citations

The preventive effect of cyclosporin A, an immunosuppressant, on the late onset reduction of muscarinic acetylcholine receptors in gerbil hippocampus after transient forebrain ischemia

1993 • 42 citations

Activation of brain calcineurin towards proteins containing Thr(P) and Ser(P) by Ca2+, calmodulin, Mg2+ and transition metal ions

1984 • 41 citations

The synapsin I brain distribution in ischemia

1992 • 40 citations

Neuromodulin (GAP-43) Can Regulate a Calmodulin-Dependent Target in vitro

1994 • 40 citations

A facilitatory effect on the induction of long-term potentiation in vivo by chronic administration of antisense oligodeoxynucleotides against catalytic subunits of calcineurin

1996 • 40 citations

Cyclosporin A stimulation of glucose-induced insulin secretion in MIN6 cells.

1996 • 38 citations

Distribution and Activity of Calcineurin in Rat Tissues

1995 • 37 citations

Factors responsible for the Ca²⁺‐dependent inactivation of calcineurin in brain

1995 • 37 citations

Phosphoprotein B-50 and phosphoinositides in brain synaptic plasma membranes: a possible feedback relationship

1986 • 36 citations

Phosphorylation of DARPP‐32 Is Regulated by GABA in Rat Striatum and Substantia Nigra

1994 • 36 citations

Striatonigral involvement following transient focal cerebral ischemia in the rats: an immunohistochemical study on a reversible ischemia model

1993 • 35 citations

Calcineurin in the adult rat hippocampus: different distribution in CA1 and CA3 subfields

1997 • 30 citations

Calcium-dependent component of massive increase in extracellular potassium during cerebral ischemia as demonstrated by microdialysis in vivo

1991 • 29 citations

Alteration in the immunoreactivity of the calcineurin subunits after ischemic hippocampal damage

1992 • 27 citations

Chronic infusion of nerve growth factor does not rescue pyramidal cells after transient forebrain ischemia in the rat

1992 • 26 citations

Calcium-Dependent Inhibition of Constitutive Nitric Oxide Synthase

1994 • 26 citations

Microtubule‐associated protein autophosphorylation alters in vitro microtubule dynamic instability

1992 • 25 citations

Absence of early destructive changes of cytoskeletal proteins after transient ischemia in the rat

1992 • 24 citations

Immunohistochemical localization of calcineurin, calmodulin-stimulated phosphatase, in the rat hippocampus using a monoclonal antibody

1987 • 22 citations

Phosphorylation of Dynamin by CDC2 Kinase

1994 • 22 citations

Compromised mitochondrial function results in dephosphorylation of tau through a calcium-dependent process in rat brain cerebral cortical slices

1994 • 20 citations

Demonstration of calmodulin-stimulated phosphatase isozymes by monoclonal antibodies.

1990 • 19 citations

RNA synthesis and processing in the gerbil brain after transient hindbrain ischaemia

1990 • 19 citations

Pharmacological protection against the toxicity of N-methyl-d-aspartate in immature rat cerebellar slices

1987 • 18 citations

Cyclosporin A and FK-506 both affect DNA binding of regulatory nuclear proteins to the human interleukin-2 promoter.

1991 • 16 citations

Phosphorylation of calcineurin: Effect on calmodulin binding

1990 • 11 citations

Protein kinase C activity in permanent focal cerebral ischemia

1992 • 9 citations

Longevity of synaptic depression in the hippocampal dentate gyrus

1992 • 8 citations