Calcineurin-mediated protein dephosphorylation in brain nerve terminals regulates the release of glutamate.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

1991 • 4,043 citations

Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Specificity and kinetics

1988 • 1,699 citations

Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation

1992 • 1,634 citations

Chemistry and Biology of the Immunophilins and Their Immunosuppressive Ligands

1991 • 1,479 citations

Okadaic acid: a new probe for the study of cellular regulation

1990 • 1,396 citations

Synaptic Vesicle Phosphoproteins and Regulation of Synaptic Function

1993 • 1,302 citations

FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin

1992 • 865 citations

Effects of the tumour promoter okadaic acid on intracellular protein phosphorylation and metabolism

1989 • 848 citations

Dynamin-like protein encoded by the Drosophila shibire gene associated with vesicular traffic

1991 • 757 citations

Mutations in human dynamin block an intermediate stage in coated vesicle formation

1993 • 702 citations

The GTPase dynamin binds to and is activated by a subset of SH3 domains

1993 • 557 citations

Multiple forms of dynamin are encoded by shibire, a Drosophila gene involved in endocytosis

1991 • 543 citations

Characterization of ionomycin as a calcium ionophore.

1978 • 535 citations

Calcium‐Dependent and‐Independent Release of Glutamate from Synaptosomes Monitored by Continuous Fluorometry

1987 • 459 citations

Effects of mutant rat dynamin on endocytosis

1993 • 453 citations

A rapid method for isolation of synaptosomes on Percoll gradients

1986 • 421 citations

Depolarization-induced phosphorylation of specific proteins, mediated by calcium ion influx, in rat brain synaptosomes.

1977 • 393 citations

Activation of NMDA receptors induces dephosphorylation of DARPP-32 in rat striatal slices

1990 • 356 citations

Molecular cloning of the microtubule-associated mechanochemical enzyme dynamin reveals homology with a new family of GTP-binding proteins

1990 • 352 citations

High brain densities of the immunophilin FKBP colocalized with calcineurin

1992 • 340 citations

Reversible blockage of membrane retrieval and endocytosis in the garland cell of the temperature-sensitive mutant of Drosophila melanogaster, shibirets1.

1983 • 332 citations

Repetitive Action Potentials in Isolated Nerve Terminals in the Presence of 4‐Aminopyridine: Effects on Cytosolic Free Ca²⁺ and Glutamate Release

1989 • 297 citations

Multiple phosphorylation sites in protein I and their differential regulation by cyclic AMP and calcium.

1979 • 284 citations

Dynamin GTPase regulated by protein kinase C phosphorylation in nerve terminals

1993 • 272 citations

Identification of an autoinhibitory domain in calcineurin.

1990 • 268 citations

The immunosuppressive and toxic effects of FK-506 are mechanistically related: pharmacology of a novel antagonist of FK-506 and rapamycin.

1992 • 254 citations

Differential phosphorylation of multiple sites in purified protein I by cyclic AMP-dependent and calcium-dependent protein kinases.

1981 • 233 citations

Activation of NMDA receptors induces rapid dephosphorylation of the cytoskeletal protein MAP2

1990 • 220 citations

Dynamin is a GTPase stimulated to high levels of activity by microtubules

1992 • 211 citations

Reversible alteration in the neuromuscular junctions of Drosophila melanogaster bearing a temperature-sensitive mutation, shibire.

1979 • 193 citations

Activation of dynamin GTPase by acidic phospholipids and endogenous rat brain vesicles

1993 • 164 citations

Transmitter Glutamate Release from Isolated Nerve Terminals: Evidence for Biphasic Release and Triggering by Localized Ca²⁺

1991 • 158 citations

Structure-activity relationship within a series of okadaic acid derivatives

1990 • 139 citations

Localized Ca2+ entry preferentially effects protein dephosphorylation, phosphorylation, and glutamate release.

1992 • 136 citations

Protein phosphorylation in nerve terminals: comparison of calcium/calmodulin-dependent and calcium/diacylglycerol-dependent systems

1988 • 122 citations

Reversible control of synaptic transmission in a single gene mutant of Drosophila melanogaster.

1983 • 116 citations

Synaptic transmission reversibly conditioned by single-gene mutation in Drosophila melanogaster

1976 • 108 citations

The role of protein kinase C and its neuronal substrates dephosphin, B-50, and MARCKS in neurotransmitter release

1991 • 104 citations

Neurologic Complications of Immunosuppressive Agents

1988 • 102 citations

Membrane potential has no direct role in evoking neurotransmitter release

1988 • 102 citations

Cyclophilins: a new family of proteins involved in intracellular folding

1992 • 100 citations

The estimation of free calcium within synaptosomes and mitochondria with fura-2; comparison to quin-2

1987 • 96 citations

The relationship between the number of synaptic vesicles and the amount of transmitter released

1989 • 85 citations

Depolarisation‐Dependent Protein Phosphorylation in Rat Cortical Synaptosomes: Factors Determining the Magnitude of the Response

1983 • 83 citations

Depolarization‐Dependent Protein Phosphorylation in Rat Cortical Synaptosomes: Characterization of Active Protein Kinases by Phosphopeptide Analysis of Substrates

1986 • 64 citations

Depolarisation‐Dependent Protein Phosphorylation and Dephosphorylation in Rat Cortical Synaptosomes Is Modulated by Calcium

1985 • 63 citations

Cyclosporin A inhibits degranulation of rat basophilic leukemia cells and human basophils. Inhibition of mediator release without affecting PI hydrolysis or Ca2+ fluxes.

1990 • 62 citations

Mechanisms in the regulation of neurotransmitter release from brain nerve terminals: Current hypotheses

1993 • 61 citations

Dephosphorylation of Synaptosomal Proteins P96 and P139 Is Regulated by Both Depolarization and Calcium, but Not by a Rise in Cytosolic Calcium Alone

1987 • 48 citations

Introduction of Impermeant Molecules into Synaptosomes Using Freeze/Thaw Permeabilization

1989 • 36 citations

Barium Evokes Glutamate Release from Rat Brain Synaptosomes by Membrane Depolarization: Involvement of K⁺, Na⁺, and Ca²⁺ Channels

1993 • 31 citations

Modulation of synaptosomal protein phosphorylation/dephosphorylation by calcium is antagonised by inhibition of protein phosphatases with okadaic acid

1991 • 31 citations

Quantitative subcellular localization of calmodulin-dependent phosphatase in chick forebrain

1988 • 28 citations

Calmodulin-dependent protein phosphatase: immunocytochemical localization in chick retina.

1985 • 28 citations

Conditions Restricting Depolarization‐Dependent Calcium Influx in Synaptosomes Reveal a Graded Response of P96 Dephosphorylation and a Transient Dephosphorylation of P65

1991 • 12 citations