Permeability of the Blood‐Brain Barrier to the Immunosuppressive Cyclic Peptide Cyclosporin A

Graphical Evaluation of Blood-to-Brain Transfer Constants from Multiple-Time Uptake Data

1983 • 3,439 citations

FINE STRUCTURAL LOCALIZATION OF A BLOOD-BRAIN BARRIER TO EXOGENOUS PEROXIDASE

1967 • 2,534 citations

JUNCTIONS BETWEEN INTIMATELY APPOSED CELL MEMBRANES IN THE VERTEBRATE BRAIN

1969 • 2,408 citations

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites.

1989 • 1,744 citations

The Concept of a Blood-Brain Barrier

1980 • 812 citations

Relationship of octanol/water partition coefficient and molecular weight to rat brain capillary permeability

1980 • 799 citations

Effects of the new anti-lymphocytic peptide cyclosporin A in animals.

1977 • 710 citations

Receptor-mediated endocytosis: insights from the lipoprotein receptor system.

1979 • 701 citations

Lipoproteins and their receptors in the central nervous system. Characterization of the lipoproteins in cerebrospinal fluid and identification of apolipoprotein B,E(LDL) receptors in the brain.

1987 • 696 citations

Measurement of brain uptake of radiolabeled substances using a tritiated water internal standard

1970 • 546 citations

Transglutaminase is essential in receptor-mediated endocytosis of α2-macroglobulin and polypeptide hormones

1980 • 535 citations

Transport of α-Aminoisobutyric Acid across Brain Capillary and Cellular Membranes

1983 • 510 citations

Lower limits of cerebrovascular permeability to nonelectrolytes in the conscious rat

1978 • 444 citations

Transport of Steroid Hormones through the Rat Blood-Brain Barrier

1979 • 422 citations

Calculation of cerebral glucose phosphorylation from brain uptake of glucose analogs in vivo: A re-examination

1982 • 409 citations

Cyclosporin A, ein immunsuppressiv wirksamer Peptidmetabolit ausTrichoderma polysporum(L<scp>INK</scp>ex P<scp>ERS</scp>.)Rifai

1976 • 373 citations

High‐ and Low‐Affinity Transport of D‐Glucose from Blood to Brain

1981 • 325 citations

Apolipoproteins in human cerebrospinal fluid.

1979 • 282 citations

Quantitative aspects of reversible osmotic opening of the blood-brain barrier

1980 • 276 citations

Role of lipoproteins and erythrocytes in the in vitro binding and distribution of cyclosporin A in the blood

1982 • 271 citations

Measurement of Solute Transport Across the Blood–Brain Barrier in the Perfused Guinea Pig Brain: Method and Application to N‐Methyl‐α‐Aminoisobutyric Acid

1986 • 152 citations

Low‐Density Lipoprotein Receptor on Endothelium of Brain Capillaries

1989 • 136 citations

Transport of Leucine‐Enkephalin Across the Blood‐Brain Barrier in the Perfused Guinea Pig Brain

1987 • 120 citations

Blood-brain barrier permeability to leucine-enkephalin,d-Alanine2-d-leucine5-enkephalin and their N-terminal amino acid (tyrosine)

1985 • 112 citations

Restrictive Transport of a Lipid‐Soluble Peptide (Cyclosporin) Through the Blood–Brain Barrier

1985 • 100 citations

Permeability of the blood-cerebrospinal fluid and blood-brain barriers to thyrotropin-releasing hormone

1985 • 93 citations

Tissue distribution, disposition, and metabolism of cyclosporine in rats.

1987 • 90 citations

Slow Penetration of Thyrotropin‐Releasing Hormone Across the Blood‐Brain Barrier of an In Situ Perfused Guinea Pig Brain

1988 • 89 citations

Blood—Brain Barrier Transport of Butanol and Water Relative to N-Isopropyl-p-Iodoamphetamine as the Internal Reference

1985 • 86 citations

Neue Cyclopeptide aus Trichoderma polysporum (L<scp>INK EX</scp> P<scp>ERS</scp>.) R<scp>IFAI</scp>: Die Cyclosporine B, D und E

1977 • 59 citations

Influence of blood components on the tissue uptake indices of cyclosporin in rats.

1988 • 59 citations

Effect of Dexamethasone on Transport of α‐Aminoisobutyric Acid and Sucrose Across the Blood‐Brain Barrier

1988 • 54 citations

Blood–Brain Glucose Transport in the Conscious Rat: Comparison of the Intravenous and Intracarotid Injection Methods

1980 • 39 citations

Uptake of leucine and alanine by cultured cerebral capillary endothelial cells

1989 • 39 citations

Saturable mechanism for delta sleep-inducing peptide (DSIP) at the blood-brain barrier of the vascularly perfused guinea pig brain

1989 • 31 citations

Oxford reviews of reproductive biology vol. 16, 1994

1995 • 28 citations

The dependence of the blood to brain passage of radioactive sodium on blood pressure and temperature

1975 • 25 citations

Blood and tissue distribution of cyclosporin A after a single oral dose in the rat

1984 • 19 citations

Experimental psychosis and transport of amino acids and peptides across the blood-brain barrier

1988 • 4 citations