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Purification and characterization of a brain-specific protein kinase C substrate, neurogranin (p17). Identification of a consensus amino acid sequence between neurogranin and neuromodulin (GAP43) that corresponds to the protein kinase C phosphorylation site and the calmodulin-binding domain.

Data up to Jan 2025

Published1991
Citations274
References40

Total Citations Per Year

Abstract

References (40)

High resolution two-dimensional electrophoresis of proteins.

1975 • 19,515 citations

The molecular heterogeneity of protein kinase C and its implications for cellular regulation

1988 • 4,243 citations

Inositol phosphates and cell signalling

1989 • 4,058 citations

Inhibition of Postsynaptic PKC or CaMKII Blocks Induction But Not Expression of LTP

1989 • 1,335 citations

Potentiation of synaptic transmission in the hippocampus by phorbol esters

1986 • 647 citations

The determination of protein, oligonucleotide and peptide molecular weights by ion‐spray mass spectrometry

1988 • 592 citations

Translocation of Protein Kinase C Activity May Mediate Hippocampal Long-Term Potentiation

1986 • 532 citations

Growth-associated protein, GAP-43, a polypeptide that is induced when neurons extend axons, is a component of growth cones and corresponds to pp46, a major polypeptide of a subcellular fraction enriched in growth cones.

1986 • 526 citations

G0 is a major growth cone protein subject to regulation by GAP-43

1990 • 422 citations

Development of neuronal polarity: GAP-43 distinguishes axonal from dendritic growth cones

1988 • 413 citations

Cloning of Complementary DNA for GAP-43, a Neuronal Growth-Related Protein

1987 • 351 citations

Regulation of calmodulin binding to P-57. A neurospecific calmodulin binding protein.

1987 • 334 citations

The influence of basic residues on the substrate specificity of protein kinase C.

1987 • 287 citations

Imaging of Memory-Specific Changes in the Distribution of Protein Kinase C in the Hippocampus

1989 • 271 citations

Identification and characterization of the calmodulin-binding domain of neuromodulin, a neurospecific calmodulin-binding protein.

1988 • 262 citations

Peptide and protein analysis by electrospray ionization-mass spectrometry and capillary electrophoresis-mass spectrometry

1989 • 256 citations

Phorbol esters block a voltage-sensitive chloride current in hippocampal pyramidal cells

1986 • 233 citations

Structures of N-terminally acetylated proteins

1985 • 190 citations

Protein Kinase C Substrates from Bovine Brain

1989 • 182 citations

Elevated synthesis of an axonally transported protein correlates with axon outgrowth in normal and injured pyramidal tracts

1986 • 182 citations

Comparison of the immunocytochemical distribution of the phosphoprotein B-50 in the cerebellum and hippocampus of immature and adult rat brain

1986 • 182 citations

Phosphorylation of B‐50 (GAP43) Is Correlated with Neurotransmitter Release in Rat Hippocampal Slices

1989 • 181 citations

Widespread occurrence of "87 kDa," a major specific substrate for protein kinase C.

1986 • 176 citations

Phosphorylation of DARPP-32, a dopamine- and cAMP-regulated phosphoprotein, by casein kinase II

1989 • 175 citations

Role of substrate in imparting calcium and phospholipid requirements to protein kinase C activation

1987 • 168 citations

Identification of the protein kinase C phosphorylation site in neuromodulin

1990 • 164 citations

Distribution and phosphorylation of the growth-associated protein GAP- 43 in regenerating sympathetic neurons in culture

1988 • 162 citations

P-57 is a neural specific calmodulin-binding protein.

1985 • 152 citations

The 87-kDa protein, a major specific substrate for protein kinase C: purification from bovine brain and characterization.

1987 • 138 citations

Characterization of the phosphorylation sites in the chicken and bovine myristoylated alanine-rich C kinase substrate protein, a prominent cellular substrate for protein kinase C

1989 • 136 citations

Comparison of S100b protein with calmodulin: interactions with melittin and microtubule-associated .tau. proteins and inhibition of phosphorylation of .tau. proteins by protein kinase C

1987 • 122 citations

B-50 phosphorylation and polyphosphoinositide metabolism in nerve growth cone membranes

1988 • 119 citations

Purification and characterization of an Mr 87,000 protein kinase C substrate from rat brain.

1987 • 117 citations

Immunochemical characterization of rat brain protein kinase C.

1986 • 110 citations

Selective conservation of GAP-43 structure in vertebrate evolution

1989 • 97 citations

The two major phosphoproteins in growth cones are probably identical to two protein kinase C substrates correlated with persistence of long- term potentiation

1989 • 88 citations

Amino acid sequence of P-57, a neurospecific calmodulin-binding protein

1987 • 68 citations

Amino acid sequence around the serine phosphorylated by casein kinase II in brain myosin heavy chain.

1990 • 61 citations

Phosphorylation of protein B-50 (GAP-43) from adult rat brain cortex by casein kinase II

1988 • 58 citations

Binding of the Neuronal Protein B-50, but Not the Metabolite B-60, to Calmodulin

1990 • 22 citations

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Purification and characterization of a brain-specific protein kinase C substrate,… (1991) – Journal of Biological Chemistry | Metascience Observatory Explorer