Alternative splicing is an efficient mechanism for the generation of protein diversity: Contractile protein genes as a model system

A catalogue of splice junction sequences

1982 • 3,861 citations

SPLICING OF MESSENGER RNA PRECURSORS

1986 • 1,233 citations

Splicing of Messenger RNA Precursors

1984 • 874 citations

A compensatory base change in U1 snRNA suppresses a 5′ splice site mutation

1986 • 755 citations

ALTERNATIVE SPLICING: A UBIQUITOUS MECHANISM FOR THE GENERATION OF MULTIPLE PROTEIN ISOFORMS FROM SINGLE GENES

1987 • 712 citations

ALTERNATIVE SPLICING IN THE CONTROL OF GENE EXPRESSION

1989 • 701 citations

PRE-mRNA SPLICING

1986 • 673 citations

Speculations on RNA splicing

1981 • 639 citations

A factor, U2AF, is required for U2 snRNP binding and splicing complex assembly

1988 • 535 citations

A protein factor, ASF, controls cell-specific alternative splicing of SV40 early pre-mRNA in vitro

1990 • 500 citations

A role for exon sequences and splice-site proximity in splice-site selection

1986 • 494 citations

The essential pre-mRNA splicing factor SF2 influences 5′ splice site selection by activating proximal sites

1990 • 454 citations

A multicomponent complex is involved in the splicing of messenger RNA precursors

1985 • 451 citations

The "Spliceosome": Yeast Pre-Messenger RNA Associates with a 40 S Complex in a Splicing-Dependent Reaction

1985 • 421 citations

Thin Filament Proteins and Thin Filament-Linked Regulation of Vertebrate Muscle Contractio

1984 • 409 citations

Identification of functional U1 snRNA-pre-mRNA complexes committed to spliceosome assembly and splicing

1989 • 391 citations

Intron splicing: a conserved internal signal in introns of animal pre-mRNAs.

1984 • 342 citations

Point mutations identify the conserved, intron-contained TACTAAC box as an essential splicing signal sequence in yeast

1984 • 339 citations

A minimal intron length but no specific internal sequence is required for splicing the large rabbit β-globin intron

1984 • 328 citations

Mammalian pre-mRNA branch site selection by U2 snRNP involves base pairing.

1989 • 314 citations

Intricate combinatorial patterns of exon splicing generate multiple regulated troponin T isoforms from a single gene

1985 • 314 citations

Molecular basis of cardiac performance. Plasticity of the myocardium generated through protein isoform switches.

1989 • 308 citations

A single cardiac troponin T gene generates embryonic and adult isoforms via developmentally regulated alternate splicing.

1985 • 305 citations

Sex-specific alternative splicing of RNA from the transformer gene results from sequence-dependent splice site blockage

1989 • 288 citations

An Early Hierarchic Role of U1 Small Nuclear Ribonucleoprotein in Spliceosome Assembly

1988 • 271 citations

Scanning from an independently specified branch point defines the 3′ splice site of mammalian introns

1989 • 267 citations

Fast skeletal muscle myosin light chains 1 and 3 are produced from a single gene by a combined process of differential RNA transcription and splicing.

1984 • 265 citations

Signals for the selection of a splice site in pre-mRNA

1987 • 247 citations

Structure of co-crystals of tropomyosin and troponin

1987 • 242 citations

Distribution of polymorphic forms of troponin components and tropomyosin in skeletal muscle

1979 • 242 citations

Mutually exclusive splicing of α-tropomyosin exons enforced by an unusual lariat branch point location: Implications for constitutive splicing

1989 • 238 citations

Structure and functions of tropomyosins from muscle and non-muscle sources

1979 • 227 citations

Splice commitment dictates neuron-specific alternative RNA processing in calcitonin/CGRP gene expression

1987 • 204 citations

Calcitonin/calcitonin gene-related peptide transcription unit: tissue-specific expression involves selective use of alternative polyadenylation sites.

1984 • 202 citations

The thin filaments of smooth muscles

1985 • 194 citations

Nonmuscle and Muscle Tropomyosin Isoforms Are Expressed from a Single Gene by Alternative RNA Splicing and Polyadenylation

1986 • 190 citations

A conserved CATTCCT motif is required for skeletal muscle-specific activity of the cardiac troponin T gene promoter.

1988 • 183 citations

UACUAAC is the preferred branch site for mammalian mRNA splicing.

1989 • 180 citations

Specific and stable intron-factor interactions are established early during in vitro pre-mRNA splicing

1985 • 180 citations

Alpha-tropomyosin gene organization. Alternative splicing of duplicated isotype-specific exons accounts for the production of smooth and striated muscle isoforms.

1987 • 174 citations

Differentiation of troponin in cardiac and skeletal muscles in chicken embryos as studied by immunofluorescence microscopy.

1981 • 172 citations

The Rat α-Tropomyosin Gene Generates a Minimum of Six Different mRNAs Coding for Striated, Smooth, and Nonmuscle Isoforms by Alternative Splicing

1988 • 167 citations

Isolation and functional comparison of bovine cardiac troponin T isoforms.

1987 • 164 citations

Generation of Protein Isoform Diversity by Alternative Splicing: Mechanistic and Biological Implications

1987 • 163 citations

Effect of different troponin T-tropomyosin combinations on thin filament activation

1987 • 161 citations

Binding of troponin-T fragments to several types of tropomyosin. Sensitivity to Ca2+ in the presence of troponin-C.

1982 • 161 citations

A novel mechanism of alternative RNA splicing for the developmentally regulated generation of troponin T isoforms from a single gene

1984 • 157 citations

Regulated Splicing of the Drosophila P Transposable Element Third Intron in Vitro: Somatic Repression

1990 • 149 citations

Complete nucleotide sequence of the fast skeletal troponin T gene

1986 • 146 citations

Multiple interactions between the splicing substrate and small nuclear ribonucleoproteins in spliceosomes.

1987 • 143 citations

Developmentally induced, muscle-specific trans factors control the differential splicing of alternative and constitutive troponin T exons

1987 • 126 citations

Evidence that a regulatory gene autoregulates splicing of its transcript.

1987 • 123 citations

Neuron-specific alternative RNA processing in transgenic mice expressing a metallothionein-calcitonin fusion gene

1987 • 123 citations

Factors influencing alternative splice site utilization in vivo.

1987 • 120 citations

Alternative splicing of tropomyosin pre-mRNAs in vitro and in vivo.

1988 • 115 citations

Comparison of α-tropomyosin sequences from smooth and striated muscle

1985 • 114 citations

A Single Troponin T Gene Regulated by Different Programs in Cardiac and Skeletal Muscle Development

1984 • 113 citations

Three novel brain tropomyosin isoforms are expressed from the rat alpha-tropomyosin gene through the use of alternative promoters and alternative RNA processing.

1990 • 112 citations

Spontaneous splicing mutations at the dihydrofolate reductase locus in Chinese hamster ovary cells.

1986 • 109 citations

Nonmuscle and muscle tropomyosin isoforms are expressed from a single gene by alternative RNA splicing and polyadenylation.

1986 • 106 citations

The role of the polypyrimidine stretch at the SV40 early pre-mRNA 3′ splice site in alternative splicing.

1988 • 105 citations

The rat alpha-tropomyosin gene generates a minimum of six different mRNAs coding for striated, smooth, and nonmuscle isoforms by alternative splicing.

1988 • 103 citations

Polymorphic forms of troponin T and troponin C and their localization in striated muscle cell types

1979 • 101 citations

In vitro splicing of mutually exclusive exons from the chicken beta-tropomyosin gene: role of the branch point location and very long pyrimidine stretch.

1990 • 97 citations

Branch point selection in alternative splicing of tropomyosin pre-mRNAs

1989 • 89 citations

Isoform variants of troponin in skeletal and cardiac muscle cells cultured with and without nerves

1983 • 88 citations

Heterogeneity of contractile proteins. A continuum of troponin-tropomyosin expression in mammalian skeletal muscle.

1985 • 85 citations

Expression of the troponin complex genes: transcriptional coactivation during myoblast differentiation and independent control in heart and skeletal muscles.

1988 • 84 citations

Types of troponin components during development of chicken skeletal muscle

1981 • 78 citations

The expression of multiple forms of troponin T in chicken-fast-skeletal muscle may result from differential splicing of a single gene

1984 • 75 citations

Organization of the hTMnm gene

1988 • 68 citations

Identification of a second binding region on rabbit skeletal troponin‐T for α‐tropomyosin

1981 • 64 citations

The components of the troponin complex and development in skeletal muscle

1980 • 63 citations

The components of troponin from chicken fast skeletal muscle. A comparison of troponin T and troponin I from breast and leg muscle

1978 • 63 citations

Troponin subunit stoichiometry and content in rabbit skeletal muscle and myofibrils.

1983 • 61 citations

Expression of multiple troponin T variants in neonatal chicken breast muscle

1986 • 54 citations

Multiple cis-acting sequence elements are required for efficient splicing of simian virus 40 small-t antigen pre-mRNA.

1988 • 51 citations

Some properties of cardiac troponin T structure

1983 • 48 citations

Heterogeneity of contractile proteins. Purification and characterization of two species of troponin T from rabbit fast skeletal muscle.

1984 • 43 citations

Model for alternative RNA processing in human calcitonin gene expression

1986 • 40 citations

The binding sites of rabbit skeletal troponin-I on troponin-T

1980 • 40 citations

Identification of multiple variants of fast muscle troponin T in the chicken using monoclonal antibodies

1985 • 39 citations

Immunochemical analysis of troponin T isoforms in adult, embryonic, regenerating, and denervated chicken fast skeletal muscles

1985 • 39 citations

Many Isoforms of Fast Muscle Troponin T from Chicken Legs

1986 • 38 citations

Developmental and muscle-specific regulation of avian fast skeletal troponin T isoform expression by mRNA splicing.

1989 • 35 citations

Myosin light-chain 1/3 gene alternative splicing: cis regulation is based upon a hierarchical compatibility between splice sites.

1990 • 35 citations

Transcriptional repression of an embryo-specific muscle gene

1988 • 34 citations

Comparison of the structure of two cardiac troponin T isoforms

1985 • 34 citations

Avian tropomyosin gene expression

1989 • 30 citations

Developmental and Muscle-specific Regulation of Avian Fast Skeletal Troponin T Isoform Expression by mRNA Splicing

1989 • 26 citations

Hydrodynamic properties of bovine cardiac troponin-I and troponin-T.

1983 • 23 citations