Caspase-dependent Activation of Calpain during Drug-induced Apoptosis

Apoptosis by Death Factor

1997 • 5,038 citations

Caspases: the executioners of apoptosis

1997 • 4,674 citations

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

1995 • 4,003 citations

Caspases: killer proteases

1997 • 2,440 citations

Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis.

1993 • 1,888 citations

DFF, a Heterodimeric Protein That Functions Downstream of Caspase-3 to Trigger DNA Fragmentation during Apoptosis

1997 • 1,848 citations

Movement of Bax from the Cytosol to Mitochondria during Apoptosis

1997 • 1,805 citations

Proteases to die for

1998 • 1,241 citations

Caspase-3-Generated Fragment of Gelsolin: Effector of Morphological Change in Apoptosis

1997 • 1,233 citations

Cytosol-to-membrane redistribution of Bax and Bcl-X_Lduring apoptosis

1997 • 1,117 citations

Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis

1998 • 1,100 citations

BAX-induced cell death may not require interleukin 1β-converting enzyme-like proteases

1996 • 911 citations

Cytochrome c: Can't Live with It—Can't Live without It

1997 • 768 citations

Inhibition of Ced-3/ICE-related Proteases Does Not Prevent Cell Death Induced by Oncogenes, DNA Damage, or the Bcl-2 Homologue Bak

1997 • 555 citations

The 40-kDa subunit of DNA fragmentation factor induces DNA fragmentation and chromatin condensation during apoptosis

1998 • 534 citations

Studies of the lamin proteinase reveal multiple parallel biochemical pathways during apoptotic execution.

1995 • 524 citations

The apoptosis-necrosis paradox. Apoptogenic proteases activated after mitochondrial permeability transition determine the mode of cell death

1997 • 470 citations

Calpain activation in apoptosis

1994 • 445 citations

Non-erythroid α-spectrin breakdown by calpain and interleukin 1 β-converting-enzyme-like protease(s) in apoptotic cells: contributory roles of both protease families in neuronal apoptosis

1996 • 427 citations

Protease Involvement in Fodrin Cleavage and Phosphatidylserine Exposure in Apoptosis

1996 • 409 citations

Calpain: A Protease in Search of a Function?

1998 • 352 citations

Bax cleavage is mediated by calpain during drug-induced apoptosis

1998 • 330 citations

Drug-induced apoptosis in B-cell chronic lymphocytic leukemia: relationship between p53 gene mutation and bcl-2/bax proteins in drug resistance.

1996 • 278 citations

Caspase-Mediated Fragmentation of Calpain Inhibitor Protein Calpastatin during Apoptosis

1998 • 270 citations

Calpain Regulates Actin Remodeling during Cell Spreading

1998 • 264 citations

Cell-penetrating inhibitors of calpain

1991 • 224 citations

Cleavage of retinoblastoma protein during apoptosis: an interleukin 1 beta-converting enzyme-like protease as candidate.

1996 • 204 citations

Calpain, an upstream regulator of thymocyte apoptosis.

1997 • 191 citations

Inhibition of caspase activity induces a switch from apoptosis to necrosis

1998 • 189 citations

Proteolysis by Calpains: a Possible Contribution to Degradation of p53

1997 • 162 citations

Regulation of Cyclin D1 by Calpain Protease

1997 • 159 citations

Calpain: A Cytosolic Proteinase Active at the Membranes

1997 • 154 citations

Active site-directed antibodies identify calpain II as an early-appearing and pervasive component of neurofibrillary pathology in Alzheimer's disease

1997 • 150 citations

Rapid Calpain I Activation and Cytoskeletal Protein Degradation Following Traumatic Spinal Cord Injury: Attenuation with Riluzole Pretreatment

1997 • 137 citations

Constitutive Apoptosis in Human Neutrophils Requires Synergy between Calpains and the Proteasome Downstream of Caspases

1998 • 120 citations

The involvement of calpain-independent proteolysis of the tumor suppressor NF2 (merlin) in schwannomas and meningiomas

1998 • 119 citations

Calcium/Calmodulin-dependent Protein Kinase IV Is Cleaved by Caspase-3 and Calpain in SH-SY5Y Human Neuroblastoma Cells Undergoing Apoptosis

1998 • 108 citations

Calpain Regulation of Cytoskeletal Signaling Complexes in Von Willebrand Factor-stimulated Platelets

1997 • 103 citations

Development and Therapeutic Potential of Calpain Inhibitors

1996 • 91 citations

m-Calpain (calcium-activated neutral proteinase) in Alzheimer's disease brains

1998 • 89 citations

Neuronal Nitric Oxide Synthase and Calmodulin‐Dependent Protein Kinase IIα Undergo Neurotoxin‐Induced Proteolysis

1997 • 80 citations

Calpain-mediated regulation of NMDA receptor structure and function

1998 • 79 citations

Temporal relationships between de novo protein synthesis, calpain and caspase 3-like protease activation, and DNA fragmentation during apoptosis in septo-hippocampal cultures

1998 • 78 citations

Glycine-induced long-term potentiation is associated with structural and functional modifications of α-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid receptors

1997 • 77 citations

Chemical hypoxia triggers apoptosis of cultured neonatal rat cardiac myocytes: modulation by calcium-regulated proteases and protein kinases.

1998 • 72 citations

Cleavage of the Cytoplasmic Domain of the Integrin β3 Subunit during Endothelial Cell Apoptosis

1998 • 56 citations

Expression of three calpain isoform genes in human skeletal muscles

1998 • 46 citations

Calpain Inhibitors Protect Against Depolarization‐induced Neurofilament Protein Loss of Septo‐hippocampal Neurons in Culture

1996 • 28 citations