Treating B-cell cancer with T cells expressing anti-CD19 chimeric antigen receptors

Chimeric Antigen Receptor–Modified T Cells in Chronic Lymphoid Leukemia

2011 • 3,283 citations

Cancer Regression in Patients After Transfer of Genetically Engineered Lymphocytes

2006 • 2,500 citations

T Cells with Chimeric Antigen Receptors Have Potent Antitumor Effects and Can Establish Memory in Patients with Advanced Leukemia

2011 • 2,257 citations

Durable Complete Responses in Heavily Pretreated Patients with Metastatic Melanoma Using T-Cell Transfer Immunotherapy

2011 • 1,934 citations

Adoptive immunotherapy for cancer: harnessing the T cell response

2012 • 1,570 citations

Tumor Regression in Patients With Metastatic Synovial Cell Sarcoma and Melanoma Using Genetically Engineered Lymphocytes Reactive With NY-ESO-1

2011 • 1,511 citations

Salvage Regimens With Autologous Transplantation for Relapsed Large B-Cell Lymphoma in the Rituximab Era

2010 • 1,465 citations

Long-Term Results of the R-CHOP Study in the Treatment of Elderly Patients With Diffuse Large B-Cell Lymphoma: A Study by the Groupe d'Etude des Lymphomes de l'Adulte

2005 • 1,454 citations

Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the gamma or zeta subunits of the immunoglobulin and T-cell receptors.

1993 • 1,433 citations

B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor–transduced T cells

2011 • 1,388 citations

Inducible Apoptosis as a Safety Switch for Adoptive Cell Therapy

2011 • 1,346 citations

The revised International Prognostic Index (R-IPI) is a better predictor of outcome than the standard IPI for patients with diffuse large B-cell lymphoma treated with R-CHOP

2006 • 1,336 citations

Adoptive Cell Therapy for Patients With Metastatic Melanoma: Evaluation of Intensive Myeloablative Chemoradiation Preparative Regimens

2008 • 1,304 citations

Eradication of B-lineage cells and regression of lymphoma in a patient treated with autologous T cells genetically engineered to recognize CD19

2010 • 1,258 citations

Safety and persistence of adoptively transferred autologous CD19-targeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemias

2011 • 1,220 citations

A Phase I Study on Adoptive Immunotherapy Using Gene-Modified T Cells for Ovarian Cancer

2006 • 1,146 citations

Virus-specific T cells engineered to coexpress tumor-specific receptors: persistence and antitumor activity in individuals with neuroblastoma

2008 • 1,144 citations

Chimeric Receptors Containing CD137 Signal Transduction Domains Mediate Enhanced Survival of T Cells and Increased Antileukemic Efficacy In Vivo

2009 • 1,067 citations

Antitumor activity and long-term fate of chimeric antigen receptor–positive T cells in patients with neuroblastoma

2011 • 1,038 citations

Removal of homeostatic cytokine sinks by lymphodepletion enhances the efficacy of adoptively transferred tumor-specific CD8+ T cells

2005 • 1,000 citations

CD28 costimulation improves expansion and persistence of chimeric antigen receptor–modified T cells in lymphoma patients

2011 • 954 citations

Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cells

2005 • 916 citations

Human T-lymphocyte cytotoxicity and proliferation directed by a single chimeric TCRζ /CD28 receptor

2002 • 912 citations

The cytoplasmic domain of the T cell receptor ζ chain is sufficient to couple to receptor-associated signal transduction pathways

1991 • 782 citations

Chimeric receptors with 4-1BB signaling capacity provoke potent cytotoxicity against acute lymphoblastic leukemia

2004 • 746 citations

Cyclophosphamide-facilitated adoptive immunotherapy of an established tumor depends on elimination of tumor-induced suppressor T cells.

1982 • 640 citations

Eradication of systemic B-cell tumors by genetically targeted human T lymphocytes co-stimulated by CD80 and interleukin-15

2003 • 630 citations

Decade-Long Safety and Function of Retroviral-Modified Chimeric Antigen Receptor T Cells

2012 • 608 citations

Monoculture-derived T lymphocytes specific for multiple viruses expand and produce clinically relevant effects in immunocompromised individuals

2006 • 542 citations

B4, a human B lymphocyte-associated antigen expressed on normal, mitogen-activated, and malignant B lymphocytes.

1983 • 517 citations

Antitransgene Rejection Responses Contribute to Attenuated Persistence of Adoptively Transferred CD20/CD19-Specific Chimeric Antigen Receptor Redirected T Cells in Humans

2010 • 502 citations

CD28 Costimulation Provided through a CD19-Specific Chimeric Antigen Receptor EnhancesIn vivoPersistence and Antitumor Efficacy of Adoptively Transferred T Cells

2006 • 463 citations

Long-term follow-up of hematologic relapse-free survival in a phase 2 study of blinatumomab in patients with MRD in B-lineage ALL

2012 • 453 citations

The promise and potential pitfalls of chimeric antigen receptors

2009 • 446 citations

Genetically Targeted T Cells Eradicate Systemic Acute Lymphoblastic Leukemia Xenografts

2007 • 442 citations

Sinks, suppressors and antigen presenters: how lymphodepletion enhances T cell-mediated tumor immunotherapy

2004 • 439 citations

Indications for allogeneic stem cell transplantation in chronic lymphocytic leukemia: the EBMT transplant consensus

2006 • 391 citations

Construction and Preclinical Evaluation of an Anti-CD19 Chimeric Antigen Receptor

2009 • 372 citations

Adoptive transfer of syngeneic T cells transduced with a chimeric antigen receptor that recognizes murine CD19 can eradicate lymphoma and normal B cells

2010 • 342 citations

Increased intensity lymphodepletion and adoptive immunotherapy—how far can we go?

2006 • 333 citations

CD19 Antigen in Leukemia and Lymphoma Diagnosis and Immunotherapy

1995 • 305 citations

Cell transfer immunotherapy for metastatic solid cancer—what clinicians need to know

2011 • 303 citations

Long-term Outcomes Among Older Patients Following Nonmyeloablative Conditioning and Allogeneic Hematopoietic Cell Transplantation for Advanced Hematologic Malignancies

2011 • 299 citations

Manufacturing Validation of Biologically Functional T Cells Targeted to CD19 Antigen for Autologous Adoptive Cell Therapy

2009 • 292 citations

A Herceptin-Based Chimeric Antigen Receptor with Modified Signaling Domains Leads to Enhanced Survival of Transduced T Lymphocytes and Antitumor Activity

2009 • 283 citations

The Role of Extracellular Spacer Regions in the Optimal Design of Chimeric Immune Receptors

2005 • 283 citations

Complete responses of relapsed lymphoma following genetic modification of tumor-antigen presenting cells and T-lymphocyte transfer

2007 • 279 citations

In VivoPersistence, Tumor Localization, and Antitumor Activity of CAR-Engineered T Cells Is Enhanced by Costimulatory Signaling through CD137 (4-1BB)

2011 • 270 citations

In vivo antitumor activity of T cells redirected with chimeric antibody/T-cell receptor genes.

1995 • 261 citations

T-cell clones can be rendered specific for CD19: toward the selective augmentation of the graft-versus-B–lineage leukemia effect

2003 • 244 citations

Lysis of ovarian cancer cells by human lymphocytes redirected with a chimeric gene composed of an antibody variable region and the Fc receptor gamma chain.

1993 • 242 citations

T-cell therapy in the treatment of post-transplant lymphoproliferative disease

2012 • 234 citations

Chimeric antigen receptors for T cell immunotherapy: current understanding and future directions

2012 • 231 citations

Detailed studies on expression and function of CD19 surface determinant by using B43 monoclonal antibody and the clinical potential of anti- CD19 immunotoxins

1988 • 222 citations

Treating cancer with genetically engineered T cells

2011 • 212 citations

Generation of CD19-chimeric antigen receptor modified CD8+ T cells derived from virus-specific central memory T cells

2011 • 191 citations

Retroviral vector integration deregulates gene expression but has no consequence on the biology and function of transplanted T cells

2006 • 188 citations

Supernatural T cells: genetic modification of T cells for cancer therapy

2005 • 149 citations

Phenotypic and Functional Attributes of Lentivirus-modified CD19-specific Human CD8+ Central Memory T Cells Manufactured at Clinical Scale

2012 • 135 citations

Conditioning regimens for allotransplants for diffuse large B-cell lymphoma: myeloablative or reduced intensity?

2012 • 132 citations

The impact of soluble tumor necrosis factor receptor etanercept on the treatment of idiopathic pneumonia syndrome after allogeneic hematopoietic stem cell transplantation

2008 • 129 citations

Update on Therapy of Chronic Lymphocytic Leukemia

2011 • 114 citations

Adoptive T cell therapy of cancer

2010 • 114 citations

Cytokine-independent growth and clonal expansion of a primary human CD8+ T-cell clone following retroviral transduction with the IL-15 gene

2007 • 109 citations

Derivation of human T lymphocytes from cord blood and peripheral blood with antiviral and antileukemic specificity from a single culture as protection against infection and relapse after stem cell transplantation

2010 • 108 citations

Infusing CD19-Directed T Cells to Augment Disease Control in Patients Undergoing Autologous Hematopoietic Stem-Cell Transplantation for Advanced B-Lymphoid Malignancies

2011 • 102 citations

Nonmyeloablative allogeneic transplantation with or without 90yttrium ibritumomab tiuxetan is potentially curative for relapsed follicular lymphoma: 12-year results

2012 • 95 citations

Differentiation of naive cord-blood T cells into CD19-specific cytolytic effectors for posttransplantation adoptive immunotherapy

2005 • 95 citations

Mantle cell lymphoma

2011 • 91 citations

In vivoInhibition of Human CD19-Targeted Effector T Cells by Natural T Regulatory Cells in a Xenotransplant Murine Model of B Cell Malignancy

2011 • 90 citations

Natural Expression of the CD19 Antigen Impacts the Long-Term Engraftment but Not Antitumor Activity of CD19-Specific Engineered T Cells

2010 • 79 citations

Comparison of Efficiency of Infection of Human Gene Therapy Target CellsviaFour Different Retroviral Receptors

1996 • 79 citations

Engineered T cells for anti-cancer therapy

2012 • 73 citations

Biologic drugs in autoinflammatory syndromes

2012 • 64 citations

Clinical Impact of Suicide Gene Therapy in Allogeneic Hematopoietic Stem Cell Transplantation

2010 • 63 citations

Antibody-mediated B-cell depletion before adoptive immunotherapy with T cells expressing CD20-specific chimeric T-cell receptors facilitates eradication of leukemia in immunocompetent mice

2009 • 59 citations

A Decade of Progress in Lymphoma: Advances and Continuing Challenges

2010 • 45 citations

Target Antigen Expression on a Professional Antigen-Presenting Cell Induces Superior Proliferative Antitumor T-Cell Responses via Chimeric T-Cell Receptors

2005 • 28 citations

Killing of non‐Hodgkin lymphoma cells by autologous CD19 engineered T cells

2005 • 22 citations

Novel agents for diffuse large B-cell lymphoma

2011 • 16 citations

Current status of allogeneic transplantation for aggressive non-Hodgkin lymphoma

2011 • 16 citations

Treatment strategies in advanced stage follicular lymphoma

2011 • 15 citations

Alternate Donor Hematopoietic Cell Transplantation (HCT) in Non-Hodgkin Lymphoma Using Lower Intensity Conditioning: A Report from the CIBMTR

2011 • 15 citations

Genetic modification of human T lymphocytes for the treatment of hematologic malignancies

2012 • 14 citations

Management of relapsed diffuse large B-cell lymphoma

2008 • 10 citations

Stem-cell transplantation for indolent lymphoma.

1999 • 10 citations

Allogeneic transplantation for lymphoma: long-term outcome

2010 • 10 citations

Stem cell transplantation for indolent lymphoma

2011 • 3 citations

Deleted Work

1955 • 0 citations