Genetically Targeted T Cells Eradicate Systemic Acute Lymphoblastic Leukemia Xenografts

The B7–CD28 superfamily

2002 • 1,646 citations

Human T-lymphocyte cytotoxicity and proliferation directed by a single chimeric TCRζ /CD28 receptor

2002 • 912 citations

Co-stimulatory members of the TNFR family: keys to effective T-cell immunity?

2003 • 848 citations

Chimeric receptors with 4-1BB signaling capacity provoke potent cytotoxicity against acute lymphoblastic leukemia

2004 • 746 citations

Eradication of systemic B-cell tumors by genetically targeted human T lymphocytes co-stimulated by CD80 and interleukin-15

2003 • 630 citations

Targeting tumours with genetically enhanced T lymphocytes

2003 • 508 citations

Chimeric Receptors Providing Both Primary and Costimulatory Signaling in T Cells from a Single Gene Product

1998 • 496 citations

CD28 Costimulation Provided through a CD19-Specific Chimeric Antigen Receptor EnhancesIn vivoPersistence and Antitumor Efficacy of Adoptively Transferred T Cells

2006 • 463 citations

A chimeric T cell antigen receptor that augments cytokine release and supports clonal expansion of primary human T cells

2005 • 456 citations

Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D

2002 • 448 citations

Activation of Resting Human Primary T Cells with Chimeric Receptors: Costimulation from CD28, Inducible Costimulator, CD134, and CD137 in Series with Signals from the TCRζ Chain

2004 • 422 citations

Effects of retroviral vector design on expression of human adenosine deaminase in murine bone marrow transplant recipients engrafted with genetically modified cells.

1995 • 357 citations

4-1BB Ligand Induces Cell Division, Sustains Survival, and Enhances Effector Function of CD4 and CD8 T Cells with Similar Efficacy

2001 • 352 citations

The CD28 family: a T-cell rheostat for therapeutic control of T-cell activation

2004 • 297 citations

The Role of Extracellular Spacer Regions in the Optimal Design of Chimeric Immune Receptors

2005 • 283 citations

Tumor-Specific T Cell Activation by Recombinant Immunoreceptors: CD3ζ Signaling and CD28 Costimulation Are Simultaneously Required for Efficient IL-2 Secretion and Can Be Integrated Into One Combined CD28/CD3ζ Signaling Receptor Molecule

2001 • 277 citations

Cancer Patient T Cells Genetically Targeted to Prostate-Specific Membrane Antigen Specifically Lyse Prostate Cancer Cells and Release Cytokines in Response to Prostate-Specific Membrane Antigen

1999 • 229 citations

Costimulation of T cells by OX40, 4-1BB, and CD27

2003 • 229 citations

Induction of human cytotoxic T lymphocytes by artificial antigen-presenting cells

2000 • 180 citations

Adoptive transfer of T cells modified with a humanized chimeric receptor gene inhibits growth of Lewis-Y-expressing tumors in mice

2005 • 146 citations

Targeted Elimination of Prostate Cancer by Genetically Directed Human T Lymphocytes

2005 • 110 citations

Integrated src kinase and costimulatory activity enhances signal transduction through single-chain chimeric receptors in T lymphocytes

2001 • 89 citations

Genetic Modification of T Lymphocytes for Adoptive Immunotherapy

2004 • 86 citations

In Vivo Visualization of Metastatic Prostate Cancer and Quantitation of Disease Progression in Immunocompromised Mice

2003 • 76 citations

Adoptive immunotherapy of prostate cancer bone lesions using redirected effector lymphocytes

2004 • 75 citations

Adoptive immunotherapy of prostate cancer bone lesions using redirected effector lymphocytes

2004 • 64 citations

Generation and Targeting of Human Tumor-Specific Tc1 and Th1 Cells Transduced with a Lentivirus Containing a Chimeric Immunoglobulin T-Cell Receptor

2004 • 62 citations

Costimulatory approaches to adoptive immunotherapy

1998 • 57 citations

Immunotherapy of Cancer Using Systemically Delivered Gene-Modified Human T Lymphocytes

2004 • 51 citations

Endothelial cell co-stimulation through OX40 augments and prolongs T cell cytokine synthesis by stabilization of cytokine mRNA

2005 • 43 citations

Biotherapy for xenografted human central nervous system leukemia in mice with severe combined immunodeficiency using B43 (anti-CD19)- pokeweed antiviral protein immunotoxin

1995 • 28 citations

Engineering T cells for cancer therapy

2005 • 25 citations

Targeting of tumor cells by lymphocytes engineered to express chimeric receptor genes

2004 • 23 citations

Current status of genetic modification of T cells for cancer treatment

2005 • 22 citations