Human T-lymphocyte cytotoxicity and proliferation directed by a single chimeric TCRζ /CD28 receptor

Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the gamma or zeta subunits of the immunoglobulin and T-cell receptors.

1993 • 1,433 citations

Increased Production of Immature Myeloid Cells in Cancer Patients: A Mechanism of Immunosuppression in Cancer

2001 • 1,309 citations

Escape of Human Solid Tumors from T–Cell Recognition: Molecular Mechanisms and Functional Significance

1999 • 1,168 citations

Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients

1999 • 1,131 citations

Expression of the prostate-specific membrane antigen.

1994 • 582 citations

Tumor antigens recognized by T cells

1997 • 552 citations

Monoclonal antibodies to the extracellular domain of prostate-specific membrane antigen also react with tumor vascular endothelium.

1997 • 509 citations

Chimeric Receptors Providing Both Primary and Costimulatory Signaling in T Cells from a Single Gene Product

1998 • 496 citations

CD28/B7 Costimulation: A Review

1998 • 447 citations

Effects of retroviral vector design on expression of human adenosine deaminase in murine bone marrow transplant recipients engrafted with genetically modified cells.

1995 • 357 citations

Eradication of Established Tumors by CD8+ T Cell Adoptive Immunotherapy

2000 • 349 citations

Antigen-dependent CD28 Signaling Selectively Enhances Survival and Proliferation in Genetically Modified Activated Human Primary T Lymphocytes

1998 • 309 citations

Tumors Promote Altered Maturation and Early Apoptosis of Monocyte-Derived Dendritic Cells

2000 • 245 citations

Cancer Patient T Cells Genetically Targeted to Prostate-Specific Membrane Antigen Specifically Lyse Prostate Cancer Cells and Release Cytokines in Response to Prostate-Specific Membrane Antigen

1999 • 229 citations

Induction of anti-self-immunity to cure cancer

1995 • 207 citations

Recombinant Retroviruses Pseudotyped With the Vesicular Stomatitis Virus G Glycoprotein Mediate Both Stable Gene Transfer and Pseudotransduction in Human Peripheral Blood Lymphocytes

1997 • 169 citations

Signaling defects in T lymphocytes of patients with malignancy

1999 • 166 citations

Strategies for immunotherapy of cancer

2000 • 165 citations

Functional expression of chimeric receptor genes in human T cells

2001 • 158 citations

CD28: a signalling perspective

1996 • 156 citations

Human Tc1 and Tc2/Tc0 CD8 T-cell clones display distinct cell surface and functional phenotypes

2000 • 153 citations

The cytoplasmic domain of CD28 is both necessary and sufficient for costimulation of interleukin-2 secretion and association with phosphatidylinositol 3'-kinase.

1994 • 145 citations

Redirecting Mouse CTL Against Colon Carcinoma: Superior Signaling Efficacy of Single-Chain Variable Domain Chimeras Containing TCR-ζ vs FcεRI-γ

2001 • 131 citations

Antigen‐specific targeting of CD28‐mediated T cell co‐stimulation using chimeric single‐chain antibody variable fragment‐CD28 receptors

1996 • 122 citations

How tumors escape immune destruction and what we can do about it

1999 • 122 citations

Negative-Feedback Regulation of CD28 Costimulation by a Novel Mitogen-Activated Protein Kinase Phosphatase, MKP6

2001 • 108 citations

Human T Lymphocyte Genetic Modification with Naked DNA

2000 • 102 citations

Analysis of CD28 cytoplasmic tail tyrosine residues as regulators and substrates for the protein tyrosine kinases, EMT and LCK.

1997 • 76 citations

Tolerance and Cancer: A Critical Issue in Tumor Immunology

1996 • 73 citations

Prostate-specific membrane antigen (PSMA)-specific monoclonal antibodies in the treatment of prostate and other cancers.

1999 • 72 citations

The internal ribosomal entry site of the encephalomyocarditis virus enables reliable coexpression of two transgenes in human primary T lymphocytes

1997 • 69 citations

Costimulatory approaches to adoptive immunotherapy

1998 • 57 citations

The TCR zeta-chain immunoreceptor tyrosine-based activation motifs are sufficient for the activation and differentiation of primary T lymphocytes.

1999 • 48 citations

The TCR ζ-Chain Immunoreceptor Tyrosine-Based Activation Motifs Are Sufficient for the Activation and Differentiation of Primary T Lymphocytes

1999 • 41 citations

How much longer will tumour cells fool the immune system?

2000 • 41 citations

Specific cytotoxic T lymphocytes in gene therapy

1997 • 36 citations

Tumor size at the time of adoptive transfer determines whether tumor rejection occurs

2000 • 34 citations

Retroviral-Mediated Gene Transfer in Primary Murine and Human T-Lymphocytes

2000 • 27 citations

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