Chimeric Receptors Containing CD137 Signal Transduction Domains Mediate Enhanced Survival of T Cells and Increased Antileukemic Efficacy In Vivo

World Health Organization Classification of Tumours: Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues

2002 • 4,781 citations

A Third-Generation Lentivirus Vector with a Conditional Packaging System

1998 • 3,175 citations

Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the gamma or zeta subunits of the immunoglobulin and T-cell receptors.

1993 • 1,433 citations

A Phase I Study on Adoptive Immunotherapy Using Gene-Modified T Cells for Ovarian Cancer

2006 • 1,146 citations

Virus-specific T cells engineered to coexpress tumor-specific receptors: persistence and antitumor activity in individuals with neuroblastoma

2008 • 1,144 citations

Human T-lymphocyte cytotoxicity and proliferation directed by a single chimeric TCRζ /CD28 receptor

2002 • 912 citations

Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors

1997 • 886 citations

Co-stimulatory members of the TNFR family: keys to effective T-cell immunity?

2003 • 848 citations

Control of large, established tumor xenografts with genetically retargeted human T cells containing CD28 and CD137 domains

2009 • 825 citations

The cytoplasmic domain of the T cell receptor ζ chain is sufficient to couple to receptor-associated signal transduction pathways

1991 • 782 citations

4-1BB Costimulatory Signals Preferentially Induce CD8+ T Cell Proliferation and Lead to the Amplification In Vivo of Cytotoxic T Cell Responses

1997 • 777 citations

Chimeric receptors with 4-1BB signaling capacity provoke potent cytotoxicity against acute lymphoblastic leukemia

2004 • 746 citations

Adoptive immunotherapy for indolent non-Hodgkin lymphoma and mantle cell lymphoma using genetically modified autologous CD20-specific T cells

2008 • 696 citations

Eradication of systemic B-cell tumors by genetically targeted human T lymphocytes co-stimulated by CD80 and interleukin-15

2003 • 630 citations

Adoptive Transfer of Chimeric Antigen Receptor Re-directed Cytolytic T Lymphocyte Clones in Patients with Neuroblastoma

2007 • 569 citations

Gene transfer in humans using a conditionally replicating lentiviral vector

2006 • 498 citations

Chimeric Receptors Providing Both Primary and Costimulatory Signaling in T Cells from a Single Gene Product

1998 • 496 citations

CD28 Costimulation Provided through a CD19-Specific Chimeric Antigen Receptor EnhancesIn vivoPersistence and Antitumor Efficacy of Adoptively Transferred T Cells

2006 • 463 citations

A chimeric T cell antigen receptor that augments cytokine release and supports clonal expansion of primary human T cells

2005 • 456 citations

Genetically Targeted T Cells Eradicate Systemic Acute Lymphoblastic Leukemia Xenografts

2007 • 442 citations

Activation of Resting Human Primary T Cells with Chimeric Receptors: Costimulation from CD28, Inducible Costimulator, CD134, and CD137 in Series with Signals from the TCRζ Chain

2004 • 422 citations

Regulated expression of telomerase activity in human T lymphocyte development and activation.

1996 • 416 citations

4-1BB Promotes the Survival of CD8+ T Lymphocytes by Increasing Expression of Bcl-xL and Bfl-1

2002 • 358 citations

Effects of CD28 costimulation on long-term proliferation of CD4+ T cells in the absence of exogenous feeder cells.

1997 • 337 citations

A Phase II Randomized Study of HIV-Specific T-Cell Gene Therapy in Subjects with Undetectable Plasma Viremia on Combination Antiretroviral Therapy

2002 • 297 citations

T cell–encoded CD80 and 4-1BBL induce auto- and transcostimulation, resulting in potent tumor rejection

2007 • 280 citations

Tumor-Specific T Cell Activation by Recombinant Immunoreceptors: CD3ζ Signaling and CD28 Costimulation Are Simultaneously Required for Efficient IL-2 Secretion and Can Be Integrated Into One Combined CD28/CD3ζ Signaling Receptor Molecule

2001 • 277 citations

Engineering Artificial Antigen-presenting Cells to Express a Diverse Array of Co-stimulatory Molecules

2007 • 253 citations

Optimizing Adoptive Polyclonal T Cell Immunotherapy of Lymphomas, Using a Chimeric T Cell Receptor Possessing CD28 and CD137 Costimulatory Domains

2007 • 209 citations

Tales of tails: regulation of telomere length and telomerase activity during lymphocyte development, differentiation, activation, and aging

1997 • 202 citations

Single-chain antigen recognition receptors that costimulate potent rejection of established experimental tumors

2002 • 186 citations

The mTOR inhibitor CCI-779 induces apoptosis and inhibits growth in preclinical models of primary adult human ALL

2005 • 167 citations

CD28 and Inducible Costimulatory Protein Src Homology 2 Binding Domains Show Distinct Regulation of Phosphatidylinositol 3-Kinase, Bcl-xL, and IL-2 Expression in Primary Human CD4 T Lymphocytes

2003 • 164 citations

IL-15-Dependent Induction of 4-1BB Promotes Antigen-Independent CD8 Memory T Cell Survival

2006 • 140 citations

Efficient lentiviral vector-mediated control of HIV-1 replication in CD4 lymphocytes from diverse HIV+ infected patients grouped according to CD4 count and viral load

2004 • 128 citations

mTOR inhibitors are synergistic with methotrexate: an effective combination to treat acute lymphoblastic leukemia

2008 • 124 citations

The role of stroma in immune recognition and destruction of well-established solid tumors

2006 • 124 citations

CD19, the earliest differentiation antigen of the B cell lineage, bears three extracellular immunoglobulin-like domains and an Epstein-Barr virus-related cytoplasmic tail.

1988 • 124 citations

Suicide gene therapy of graft-versus-host disease induced by central memory human T lymphocytes

2005 • 116 citations

Targeted Elimination of Prostate Cancer by Genetically Directed Human T Lymphocytes

2005 • 110 citations

Integrated src kinase and costimulatory activity enhances signal transduction through single-chain chimeric receptors in T lymphocytes

2001 • 89 citations

CD137 stimulation delivers an antigen-independent growth signal for T lymphocytes with memory phenotype

2007 • 85 citations

Redirected primary T cells harboring a chimeric receptor require costimulation for their antigen-specific activation

2004 • 84 citations

TNF family ligands define niches for T cell memory

2007 • 80 citations

4‐1BB enhances CD8⁺ T cell expansion by regulating cell cycle progression through changes in expression of cyclins D and E and cyclin‐dependent kinase inhibitor p27^kip1

2003 • 57 citations

Molecular portraits of B cell lineage commitment

2002 • 39 citations

Enhanced Transgene Expression in Quiescent and Activated Human CD8⁺T Cells

2004 • 32 citations

A fully human chimeric immune receptor for retargeting T-cells to CEA-expressing tumor cells.

2007 • 15 citations

T cells for suicide gene therapy: Activation, functionality and clinical relevance

2007 • 10 citations