Chimeric receptors with 4-1BB signaling capacity provoke potent cytotoxicity against acute lymphoblastic leukemia

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1995 • 2,026 citations

Reconstitution of Cellular Immunity against Cytomegalovirus in Recipients of Allogeneic Bone Marrow by Transfer of T-Cell Clones from the Donor

1995 • 1,828 citations

Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigen-specific T cells to their cognate peptide

2003 • 1,597 citations

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1997 • 1,290 citations

Use of gene-modified virus-specific T lymphocytes to control Epstein-Barr-virus-related lymphoproliferation

1995 • 1,207 citations

Complexities of CD28/B7: CTLA-4 Costimulatory Pathways in Autoimmunity and Transplantation

2001 • 1,032 citations

Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors

1997 • 886 citations

4-1BB Costimulatory Signals Preferentially Induce CD8+ T Cell Proliferation and Lead to the Amplification In Vivo of Cytotoxic T Cell Responses

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1977 • 698 citations

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Targeting tumours with genetically enhanced T lymphocytes

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1996 • 439 citations

Haematopoietic cell transplantation as immunotherapy

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Costimulation of CD28- T lymphocytes by 4-1BB ligand.

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Bone marrow-derived stromal cells prevent apoptotic cell death in B- lineage acute lymphoblastic leukemia

1992 • 265 citations

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Signals through 4-1BB are costimulatory to previously activated splenic T cells and inhibit activation-induced cell death.

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Donor leukocyte infusions in acute lymphocytic leukemia

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T-cell clones can be rendered specific for CD19: toward the selective augmentation of the graft-versus-B–lineage leukemia effect

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Amplification of tumor immunity by gene transfer of the co-stimulatory 4-1BB ligand: synergy with the CD28 co-stimulatory pathway

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Construction and characterisation of a functional CD19 specific single chain Fv fragment for immunotherapy of B lineage leukaemia and lymphoma

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Dexamethasone induces irreversible G₁ arrest and death of a human lymphoid cell line

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Synthetic activation of caspases: Artificial death switches

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Pre-B acute lymphoblastic leukemia cells may induce T-cell anergy to alloantigen

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Gene therapy for cancer using single-chain Fv fragments specific for 4-1BB

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Pre-B acute lymphoblastic leukemia cells may induce T-cell anergy to alloantigen

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Genetic Modification of Human T Cells with CD20: A Strategy to Purify and Lyse Transduced Cells with Anti-CD20 Antibodies

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Development and functional characterization of human bone marrow mesenchymal cells immortalized by enforced expression of telomerase

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Human 4-1BB regulates CD28 co-stimulation to promote Th1 cell responses

1998 • 131 citations

Immunologic potential of donor lymphocytes expressing a suicide gene for early immune reconstitution after hematopoietic T-cell–depleted stem cell transplantation

2003 • 130 citations

The Graft-Versus-Leukemia Effects of Allogeneic Cell Therapy

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Anti-4-1BB monoclonal antibody enhances rejection of large tumor burden by promoting survival but not clonal expansion of tumor-specific CD8+ T cells.

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Hyperdiploid Acute Lymphoblastic Leukemia With 51 to 65 Chromosomes: A Distinct Biological Entity With a Marked Propensity to Undergo Apoptosis

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Costimulation by CD48 and B7-1 induces immunity against poorly immunogenic tumors.

1996 • 82 citations

Interleukin-4 induces programmed cell death (apoptosis) in cases of high-risk acute lymphoblastic leukemia

1994 • 79 citations

Costimulation of human CD28^– T cells by 4‐1BB ligand

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Donor leukocyte infusions for recurrent hematologic malignancies after allogeneic bone marrow transplantation: impact of infused and residual donor T cells

1998 • 71 citations

Tumour rejection by gene transfer of 4-1BB ligand into a CD80+ murine squamous cell carcinoma and the requirements of co-stimulatory molecules on tumour and host cells

2000 • 59 citations

Costimulatory approaches to adoptive immunotherapy

1998 • 57 citations

T-Cell Depletion to Prevent Graft-Versus-Host Disease After Bone Marrow Transplantation

1990 • 54 citations

T cell activation with systemic agonistic antibody versus local 4-1BB ligand gene delivery combined with interleukin-12 eradicate liver metastases of breast cancer

2002 • 54 citations

Prevalence and Growth Characteristics of Malignant Stem Cells in B-Lineage Acute Lymphoblastic Leukemia

1997 • 50 citations

Stroma-supported immunocytometric assay (SIA): a novel method for testing the sensitivity of acute lymphoblastic leukemia cells to cytotoxic drugs.

1993 • 45 citations

Prevalence and Growth Characteristics of Malignant Stem Cells in B-Lineage Acute Lymphoblastic Leukemia

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Management of adult acute lymphoblastic leukemia: moving toward a risk-adapted approach

2001 • 28 citations

A novel adenovirus expressing human 4–1BB ligand enhances antitumor immunity

2003 • 26 citations

Interleukin-4 variant (BAY 36-1677) selectively induces apoptosis in acute lymphoblastic leukemia cells

2001 • 25 citations

Development and application of receptor-modified T lymphocytes for adoptive immunotherapy

2001 • 24 citations

The antifungal antibiotic clotrimazole alters calcium homeostasis of leukemic lymphoblasts and induces apoptosis

2002 • 18 citations

‘Ponte di Legno’ Working Group – Report on the Fifth International Childhood Acute Lymphoblastic Leukemia Workshop: Vienna, Austria, 29 April – 1 May 2002

2003 • 11 citations

Signals mediated by FcγRIIA suppress the growth of B-lineage acute lymphoblastic leukemia cells

2002 • 10 citations