Derivation of human T lymphocytes from cord blood and peripheral blood with antiviral and antileukemic specificity from a single culture as protection against infection and relapse after stem cell transplantation

Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the gamma or zeta subunits of the immunoglobulin and T-cell receptors.

1993 • 1,433 citations

Virus-specific T cells engineered to coexpress tumor-specific receptors: persistence and antitumor activity in individuals with neuroblastoma

2008 • 1,144 citations

Infusion of Cytotoxic T Cells for the Prevention and Treatment of Epstein-Barr Virus–Induced Lymphoma in Allogeneic Transplant Recipients

1998 • 1,103 citations

Transplantation of unrelated donor umbilical cord blood in 102 patients with malignant and nonmalignant diseases: influence of CD34 cell dose and HLA disparity on treatment-related mortality and survival

2002 • 1,012 citations

Tumor Regression in Cancer Patients by Very Low Doses of a T Cell–Engaging Antibody

2008 • 1,000 citations

Human T-lymphocyte cytotoxicity and proliferation directed by a single chimeric TCRζ /CD28 receptor

2002 • 912 citations

Long–term restoration of immunity against Epstein–Barr virus infection by adoptive transfer of gene–modified virus–specific T lymphocytes

1996 • 852 citations

In adults with standard-risk acute lymphoblastic leukemia, the greatest benefit is achieved from a matched sibling allogeneic transplantation in first complete remission, and an autologous transplantation is less effective than conventional consolidation/maintenance chemotherapy in all patients: final results of the International ALL Trial (MRC UKALL XII/ECOG E2993)

2007 • 760 citations

Infusion of cytomegalovirus (CMV)–specific T cells for the treatment of CMV infection not responding to antiviral chemotherapy

2002 • 710 citations

Adoptive immunotherapy for indolent non-Hodgkin lymphoma and mantle cell lymphoma using genetically modified autologous CD20-specific T cells

2008 • 696 citations

Risk of lymphoproliferative disorders after bone marrow transplantation: a multi-institutional study.

1999 • 642 citations

Eradication of systemic B-cell tumors by genetically targeted human T lymphocytes co-stimulated by CD80 and interleukin-15

2003 • 630 citations

Monoculture-derived T lymphocytes specific for multiple viruses expand and produce clinically relevant effects in immunocompromised individuals

2006 • 542 citations

How we treat cytomegalovirus in hematopoietic cell transplant recipients

2009 • 530 citations

Adoptive cellular therapy for early cytomegalovirus infection after allogeneic stem-cell transplantation with virus-specific T-cell lines

2003 • 461 citations

Cytomegalovirus in hematopoietic stem cell transplant recipients: current status, known challenges, and future strategies

2003 • 431 citations

Prolonged survival and tissue trafficking following adoptive transfer of CD4ζ gene-modified autologous CD4+ and CD8+ T cells in human immunodeficiency virus–infected subjects

2000 • 385 citations

Safe adoptive transfer of virus‐specific T‐cell immunity for the treatment of systemic adenovirus infection after allogeneic stem cell transplantation

2006 • 376 citations

Cytotoxic T lymphocyte therapy with donor T cells prevents and treats adenovirus and Epstein-Barr virus infections after haploidentical and matched unrelated stem cell transplantation

2009 • 325 citations

CD20 monoclonal antibody (rituximab) for therapy of Epstein-Barr virus lymphoma after hemopoietic stem-cell transplantation

2000 • 285 citations

Complete Remission of Accelerated Phase Chronic Myeloid Leukemia by Treatment With Leukemia-Reactive Cytotoxic T Lymphocytes

1999 • 277 citations

T lymphocytes redirected against the κ light chain of human immunoglobulin efficiently kill mature B lymphocyte-derived malignant cells

2006 • 261 citations

Donor leukocyte infusions in acute lymphocytic leukemia

2000 • 248 citations

T-cell clones can be rendered specific for CD19: toward the selective augmentation of the graft-versus-B–lineage leukemia effect

2003 • 244 citations

Functionally active virus-specific T cells that target CMV, adenovirus, and EBV can be expanded from naive T-cell populations in cord blood and will target a range of viral epitopes

2009 • 241 citations

Epstein Barr virus–specific cytotoxic T lymphocytes expressing the anti-CD30ζ artificial chimeric T-cell receptor for immunotherapy of Hodgkin disease

2007 • 230 citations

Long-term in vivo survival of receptor-modified syngeneic T cells in patients with human immunodeficiency virus infection.

2000 • 215 citations

Prolonged survival and tissue trafficking following adoptive transfer of CD4ζ gene-modified autologous CD4+ and CD8+ T cells in human immunodeficiency virus–infected subjects

2000 • 207 citations

Epstein-Barr virus–specific human T lymphocytes expressing antitumor chimeric T-cell receptors: potential for improved immunotherapy

2002 • 197 citations

Chemotherapy versus allogeneic transplantation for very-high-risk childhood acute lymphoblastic leukaemia in first complete remission: comparison by genetic randomisation in an international prospective study

2005 • 191 citations

Relapse of acute leukemia after marrow transplantation: natural history and results of subsequent therapy.

1989 • 172 citations

Graft versus host disease prophylaxis with low-dose cyclosporine-A reduces the risk of relapse in children with acute leukemia given HLA-identical sibling bone marrow transplantation: results of a randomized trial

2000 • 167 citations

Production of Genetically Modified Epstein-Barr Virus-Specific Cytotoxic T Cells for Adoptive Transfer to Patients at High Risk of EBV-Associated Lymphoproliferative Disease

1995 • 129 citations

Relapse after allogeneic bone marrow transplantation for acute leukaemia: a survey by the E.B.M.T. of 117 cases

1988 • 120 citations

Detection of adenovirus‐specific T cells in children with adenovirus infection after allogeneic stem cell transplantation

2005 • 107 citations

Mechanisms and functions for the duration of intercellular contacts made by lymphocytes

2009 • 102 citations

Immunotherapy of lymphoma and leukemia with T-cell engaging BiTE antibody blinatumomab

2009 • 97 citations

Differentiation of naive cord-blood T cells into CD19-specific cytolytic effectors for posttransplantation adoptive immunotherapy

2005 • 95 citations

Fifteen Years of Gene Therapy Based on Chimeric Antigen Receptors: “Are We Nearly There Yet?”

2009 • 92 citations

Umbilical cord blood transplantation: Pros, cons and beyond

2009 • 88 citations

Adenovirus infection after allogeneic stem cell transplantation

2007 • 75 citations

Bone marrow transplantation versus chemotherapy in the treatment of very high–risk childhood acute lymphoblastic leukemia in first remission: results from Medical Research Council UKALL X and XI

2000 • 67 citations

Treatment of relapsed acute lymphoblastic leukemia after allogeneic bone marrow transplantation with chemotherapy followed by G-CSF-primed donor leukocyte infusion: a prospective study

2005 • 55 citations

Monoclonal T-Cell Receptors: New Reagents for Cancer Therapy

2007 • 52 citations

Optimizing Unrelated Donor Cord Blood Transplantation

2009 • 42 citations

Are we nearly there yet

2005 • 35 citations

Immune Reconstitution in Children after Unrelated Cord Blood Transplantation

2007 • 33 citations

Generation and ex vivo expansion of cytotoxic T lymphocytes directed toward different types of leukemia or myelodysplastic cells using both HLA-matched and partially matched donors

2003 • 27 citations

Treatment with Anti-CD19 BiTE Antibody Blinatumomab (MT103 / MEDI-538) Is Able to Eliminate Minimal Residual Disease (MRD) in Patients with B-Precursor Acute Lymphoblastic Leukemia (ALL): First Results of An Ongoing Phase II Study.

2008 • 26 citations

Adoptive Cellular Immunotherapy with CD19-Specific T Cells

2005 • 23 citations

Expansion of antileukaemia CTL lines and clones for adoptive cell therapy in paediatric patients given allogeneic haematopoietic stem cell transplantation

2008 • 9 citations