Construction and Preclinical Evaluation of an Anti-CD19 Chimeric Antigen Receptor

Site-directed mutagenesis by overlap extension using the polymerase chain reaction

1989 • 7,496 citations

Two subsets of memory T lymphocytes with distinct homing potentials and effector functions

1999 • 5,659 citations

Cancer Regression and Autoimmunity in Patients After Clonal Repopulation with Antitumor Lymphocytes

2002 • 2,781 citations

Rituximab chimeric anti-CD20 monoclonal antibody therapy for relapsed indolent lymphoma: half of patients respond to a four-dose treatment program.

1998 • 2,777 citations

Cancer Regression in Patients After Transfer of Genetically Engineered Lymphocytes

2006 • 2,500 citations

Adoptive Cell Transfer Therapy Following Non-Myeloablative but Lymphodepleting Chemotherapy for the Treatment of Patients With Refractory Metastatic Melanoma

2005 • 1,613 citations

Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the gamma or zeta subunits of the immunoglobulin and T-cell receptors.

1993 • 1,433 citations

Vesicular stomatitis virus G glycoprotein pseudotyped retroviral vectors: concentration to very high titer and efficient gene transfer into mammalian and nonmammalian cells.

1993 • 1,395 citations

Expression of immunoglobulin-T-cell receptor chimeric molecules as functional receptors with antibody-type specificity.

1989 • 1,350 citations

A Phase I Study on Adoptive Immunotherapy Using Gene-Modified T Cells for Ovarian Cancer

2006 • 1,146 citations

Removal of homeostatic cytokine sinks by lymphodepletion enhances the efficacy of adoptively transferred tumor-specific CD8+ T cells

2005 • 1,000 citations

Human T-lymphocyte cytotoxicity and proliferation directed by a single chimeric TCRζ /CD28 receptor

2002 • 912 citations

4-1BB Costimulatory Signals Preferentially Induce CD8+ T Cell Proliferation and Lead to the Amplification In Vivo of Cytotoxic T Cell Responses

1997 • 777 citations

Chimeric receptors with 4-1BB signaling capacity provoke potent cytotoxicity against acute lymphoblastic leukemia

2004 • 746 citations

Eradication of systemic B-cell tumors by genetically targeted human T lymphocytes co-stimulated by CD80 and interleukin-15

2003 • 630 citations

B4, a human B lymphocyte-associated antigen expressed on normal, mitogen-activated, and malignant B lymphocytes.

1983 • 517 citations

Targeting tumours with genetically enhanced T lymphocytes

2003 • 508 citations

Long-Term Follow-Up and Outcome of a Large Cohort of Patients with Common Variable Immunodeficiency

2007 • 504 citations

Chimeric Receptors Providing Both Primary and Costimulatory Signaling in T Cells from a Single Gene Product

1998 • 496 citations

CD28 Costimulation Provided through a CD19-Specific Chimeric Antigen Receptor EnhancesIn vivoPersistence and Antitumor Efficacy of Adoptively Transferred T Cells

2006 • 463 citations

Genetically Targeted T Cells Eradicate Systemic Acute Lymphoblastic Leukemia Xenografts

2007 • 442 citations

Indications for allogeneic stem cell transplantation in chronic lymphocytic leukemia: the EBMT transplant consensus

2006 • 391 citations

Cutting Edge: 4-1BB Is a Bona Fide CD8 T Cell Survival Signal

1999 • 379 citations

The use of anti-CD3 and anti-CD28 monoclonal antibodies to clone and expand human antigen-specific T cells

1990 • 353 citations

CD19 Antigen in Leukemia and Lymphoma Diagnosis and Immunotherapy

1995 • 305 citations

Immunotherapy through TCR gene transfer

2001 • 287 citations

Transition of late-stage effector T cells to CD27+ CD28+ tumor-reactive effector memory T cells in humans after adoptive cell transfer therapy

2004 • 284 citations

Functional expression of B7/BB1 on activated T lymphocytes.

1993 • 271 citations

Allogeneic hematopoietic cell transplantation after fludarabine and 2 Gy total body irradiation for relapsed and refractory mantle cell lymphoma

2004 • 262 citations

In vivo antitumor activity of T cells redirected with chimeric antibody/T-cell receptor genes.

1995 • 261 citations

T-cell clones can be rendered specific for CD19: toward the selective augmentation of the graft-versus-B–lineage leukemia effect

2003 • 244 citations

Lysis of ovarian cancer cells by human lymphocytes redirected with a chimeric gene composed of an antibody variable region and the Fc receptor gamma chain.

1993 • 242 citations

Transfer of a TCR Gene Derived from a Patient with a Marked Antitumor Response Conveys Highly Active T-Cell Effector Functions

2005 • 229 citations

Detailed studies on expression and function of CD19 surface determinant by using B43 monoclonal antibody and the clinical potential of anti- CD19 immunotoxins

1988 • 222 citations

Nonablative Allogeneic Stem-Cell Transplantation for Advanced/Recurrent Mantle-Cell Lymphoma

2003 • 218 citations

The toxicity and efficacy of donor lymphocyte infusions given after reduced-intensity conditioning allogeneic stem cell transplantation

2002 • 216 citations

Optimizing Adoptive Polyclonal T Cell Immunotherapy of Lymphomas, Using a Chimeric T Cell Receptor Possessing CD28 and CD137 Costimulatory Domains

2007 • 209 citations

Construction and characterisation of a functional CD19 specific single chain Fv fragment for immunotherapy of B lineage leukaemia and lymphoma

1997 • 205 citations

The VITAL assay: a versatile fluorometric technique for assessing CTL- and NKT-mediated cytotoxicity against multiple targets in vitro and in vivo

2003 • 189 citations

Single-chain antigen recognition receptors that costimulate potent rejection of established experimental tumors

2002 • 186 citations

4-1BB Ligand-Mediated Costimulation of Human T Cells Induces CD4 and CD8 T Cell Expansion, Cytokine Production, and the Development of Cytolytic Effector Function

2002 • 181 citations

Severe immunodeficiency in patients treated with fludarabine monophosphate

1993 • 137 citations

Redirecting Mouse CTL Against Colon Carcinoma: Superior Signaling Efficacy of Single-Chain Variable Domain Chimeras Containing TCR-ζ vs FcεRI-γ

2001 • 131 citations

Functional immunoglobulin M production after transfection of cloned immunoglobulin heavy and light chain genes into lymphoid cells.

1983 • 121 citations

Expression of a hybrid immunoglobulin-T cell receptor protein in transgenic mice

1989 • 111 citations

Costimulatory ligand 4-1BBL (CD137L) as an efficient adjuvant for human antiviral cytotoxic T cell responses

2004 • 109 citations

Graft-versus-lymphoma effect of donor lymphocyte infusion in indolent lymphomas relapsed after allogeneic stem cell transplantation

2003 • 100 citations

Donor lymphocyte infusions can result in sustained remissions in patients with residual or relapsed lymphoid malignancy following allogeneic haemopoietic stem cell transplantation

2005 • 91 citations

Infectious complications of monoclonal antibodies used in cancer therapy

2007 • 87 citations

Comparison of Efficiency of Infection of Human Gene Therapy Target CellsviaFour Different Retroviral Receptors

1996 • 79 citations

Characterization and functional analysis of adult human bone marrow cell subsets in relation to B-lymphoid development

1993 • 76 citations

A Simple and Reliable Method for Screening Retroviral Producer Clones Without Selectable Markers

1997 • 57 citations

Analysis of the site of interaction of CD28 with its counter-receptors CD80 and CD86 and correlation with function.

1996 • 43 citations

Cellular immune therapy for chronic lymphocytic leukemia

2007 • 34 citations

Target Antigen Expression on a Professional Antigen-Presenting Cell Induces Superior Proliferative Antitumor T-Cell Responses via Chimeric T-Cell Receptors

2005 • 28 citations

Therapeutic options in mantle cell lymphoma

2008 • 25 citations

The evolving role of autologous and allogeneic stem cell transplantation in follicular lymphoma

2006 • 23 citations

Killing of non‐Hodgkin lymphoma cells by autologous CD19 engineered T cells

2005 • 22 citations

A First-In-Human Clinical Trial of Adoptive Therapy Using CD19-Specific Chimeric Antigen Receptor Re-Directed T-Cells for Recurrent/Refractory Follicular Lymphoma.

2007 • 22 citations

Initial Therapy for Patients With Chronic Lymphocytic Leukemia

2006 • 18 citations