Increased intensity lymphodepletion and adoptive immunotherapy—how far can we go?

New Guidelines to Evaluate the Response to Treatment in Solid Tumors

2000 • 15,583 citations

Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

2004 • 4,872 citations

The Danger Model: A Renewed Sense of Self

2002 • 4,107 citations

Cancer immunotherapy: moving beyond current vaccines

2004 • 2,932 citations

Cancer Regression and Autoimmunity in Patients After Clonal Repopulation with Antitumor Lymphocytes

2002 • 2,781 citations

Hematopoietic cell transplantation (HCT)-specific comorbidity index: a new tool for risk assessment before allogeneic HCT

2005 • 2,651 citations

Observations on the Systemic Administration of Autologous Lymphokine-Activated Killer Cells and Recombinant Interleukin-2 to Patients with Metastatic Cancer

1985 • 2,616 citations

Cancer Regression in Patients After Transfer of Genetically Engineered Lymphocytes

2006 • 2,500 citations

Reconstitution of Cellular Immunity against Cytomegalovirus in Recipients of Allogeneic Bone Marrow by Transfer of T-Cell Clones from the Donor

1995 • 1,828 citations

Successful adoptive transfer and in vivo expansion of human haploidentical NK cells in patients with cancer

2005 • 1,715 citations

Adoptive Cell Transfer Therapy Following Non-Myeloablative but Lymphodepleting Chemotherapy for the Treatment of Patients With Refractory Metastatic Melanoma

2005 • 1,613 citations

Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo

2000 • 1,596 citations

Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy

2006 • 1,499 citations

Gene Transfer into Humans — Immunotherapy of Patients with Advanced Melanoma, Using Tumor-Infiltrating Lymphocytes Modified by Retroviral Gene Transduction

1990 • 1,307 citations

Treatment of 283 Consecutive Patients With Metastatic Melanoma or Renal Cell Cancer Using High-Dose Bolus Interleukin 2

1994 • 1,070 citations

Phenotypically distinct subsets of CD4⁺ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice

1993 • 1,064 citations

Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self

2001 • 1,043 citations

Natural selection of tumor variants in the generation of “tumor escape” phenotypes

2002 • 1,014 citations

Removal of homeostatic cytokine sinks by lymphodepletion enhances the efficacy of adoptively transferred tumor-specific CD8+ T cells

2005 • 1,000 citations

Tumor Regression and Autoimmunity after Reversal of a Functionally Tolerant State of Self-reactive CD8+ T Cells

2003 • 919 citations

Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cells

2005 • 916 citations

Adoptive immunotherapy for cancer: building on success

2006 • 848 citations

Control of Homeostasis of CD8 ⁺ Memory T Cells by Opposing Cytokines

2000 • 847 citations

Selective Stimulation of T Cell Subsets with Antibody-Cytokine Immune Complexes

2006 • 843 citations

Total Body Irradiation and Acute Graft-Versus-Host Disease: The Role of Gastrointestinal Damage and Inflammatory Cytokines

1997 • 838 citations

CD8+ T Cell Immunity Against a Tumor/Self-Antigen Is Augmented by CD4+ T Helper Cells and Hindered by Naturally Occurring T Regulatory Cells

2005 • 741 citations

Organ-specific autoimmune diseases induced in mice by elimination of T cell subset. I. Evidence for the active participation of T cells in natural self-tolerance; deficit of a T cell subset as a possible cause of autoimmune disease.

1985 • 721 citations

Synergy of IL-21 and IL-15 in regulating CD8+ T cell expansion and function

2005 • 684 citations

Homeostatic Expansion of T Cells during Immune Insufficiency Generates Autoimmunity

2004 • 682 citations

Generation of Tumor-Infiltrating Lymphocyte Cultures for Use in Adoptive Transfer Therapy for Melanoma Patients

2003 • 662 citations

Naive T Cells Transiently Acquire a Memory-like Phenotype during Homeostasis-Driven Proliferation

2000 • 644 citations

Cytokine Requirements for Acute and Basal Homeostatic Proliferation of Naive and Memory CD8+ T Cells

2002 • 588 citations

Comparison of 200 mg/m2 melphalan and 8 Gy total body irradiation plus 140 mg/m2 melphalan as conditioning regimens for peripheral blood stem cell transplantation in patients with newly diagnosed multiple myeloma: final analysis of the Intergroupe Francophone du Myelome 9502 randomized trial

2002 • 562 citations

Concomitant Tumor Immunity to a Poorly Immunogenic Melanoma Is Prevented by Regulatory T Cells

2004 • 541 citations

Sublethal Irradiation of Human Tumor Cells Modulates Phenotype Resulting in Enhanced Killing by Cytotoxic T Lymphocytes

2004 • 532 citations

Total Therapy With Tandem Transplants for Newly Diagnosed Multiple Myeloma

1999 • 499 citations

CD8⁺ T‐cell memory in tumor immunology and immunotherapy

2006 • 472 citations

Tumor Progression Can Occur despite the Induction of Very High Levels of Self/Tumor Antigen-Specific CD8+ T Cells in Patients with Melanoma

2005 • 462 citations

Interleukin 7 Regulates the Survival and Generation of Memory CD4 Cells

2003 • 449 citations

Sinks, suppressors and antigen presenters: how lymphodepletion enhances T cell-mediated tumor immunotherapy

2004 • 439 citations

Melanocyte Destruction after Antigen-Specific Immunotherapy of Melanoma

2000 • 423 citations

Peripheral T Cell Survival Requires Continual Ligation of the T Cell Receptor to Major Histocompatibility Complex–Encoded Molecules

1997 • 419 citations

Circumventing tolerance to a human MDM2-derived tumor antigen by TCR gene transfer

2001 • 373 citations

Induction of T cell development and establishment of T cell competence from embryonic stem cells differentiated in vitro

2004 • 366 citations

Adoptive Transfer of Cloned Melanoma-Reactive T Lymphocytes for the Treatment of Patients with Metastatic Melanoma

2001 • 359 citations

Treatment of Epstein-Barr-virus-positive post-transplantation lymphoproliferative disease with partly HLA-matched allogeneic cytotoxic T cells

2002 • 355 citations

A Phase I Study of Nonmyeloablative Chemotherapy and Adoptive Transfer of Autologous Tumor Antigen-Specific T Lymphocytes in Patients With Metastatic Melanoma

2002 • 340 citations

Telomere Length of Transferred Lymphocytes Correlates with In Vivo Persistence and Tumor Regression in Melanoma Patients Receiving Cell Transfer Therapy

2005 • 331 citations

Morbidity and mortality with nonmyeloablative compared with myeloablative conditioning before hematopoietic cell transplantation from HLA-matched related donors

2004 • 324 citations

Comparing morbidity and mortality of HLA-matched unrelated donor hematopoietic cell transplantation after nonmyeloablative and myeloablative conditioning: influence of pretransplantation comorbidities

2004 • 324 citations

T cell homeostatic proliferation elicits effective antitumor autoimmunity

2002 • 312 citations

Restoration of immunity in lymphopenic individuals with cancer by vaccination and adoptive T-cell transfer

2005 • 294 citations

T cell homeostatic proliferation elicits effective antitumor autoimmunity

2002 • 262 citations

Recovery of immune reactivity after T-cell–depleted bone marrow transplantation depends on thymic activity

2000 • 258 citations

Cutting Edge: Recent Immune Status Determines the Source of Antigens That Drive Homeostatic T Cell Expansion

2005 • 243 citations

A phase II study of interleukin-2 and lymphokine-activated killer cells in patients with metastatic malignant melanoma.

1989 • 240 citations

Myeloablative vs nonmyeloablative allogeneic transplantation for patients with myelodysplastic syndrome or acute myelogenous leukemia with multilineage dysplasia: a retrospective analysis

2005 • 239 citations

Recovery of immune reactivity after T-cell–depleted bone marrow transplantation depends on thymic activity

2000 • 231 citations

Transfer of a TCR Gene Derived from a Patient with a Marked Antitumor Response Conveys Highly Active T-Cell Effector Functions

2005 • 229 citations

Reconstitution of the T-Cell Compartment After Bone Marrow Transplantation: Restoration of the Repertoire by Thymic Emigrants

1998 • 223 citations

IDIOPATHIC PNEUMONIA SYNDROME

1997 • 222 citations

CD4+CD25+ T Regulatory Cells, Immunotherapy of Cancer, and Interleukin-2

2005 • 214 citations

Tumors as elusive targets of T-cell-based active immunotherapy

2003 • 208 citations

Hematopoietic stem cell transplantation for progressive multiple sclerosis: failure of a total body irradiation–based conditioning regimen to prevent disease progression in patients with high disability scores

2003 • 207 citations

Essential Role of the Thymus to Reconstitute Naive (CD45RA+) T-Helper Cells After Human Allogeneic Bone Marrow Transplantation

1997 • 204 citations

Hematopoietic stem cells promote the expansion and function of adoptively transferred antitumor CD8+ T cells

2007 • 201 citations

Preterminal host dendritic cells in irradiated mice prime CD8+ T cell–mediated acute graft-versus-host disease

2002 • 197 citations

Adoptive transfer of costimulated T cells induces lymphocytosis in patients with relapsed/refractory non-Hodgkin lymphoma following CD34+-selected hematopoietic cell transplantation

2003 • 186 citations

Preterminal host dendritic cells in irradiated mice prime CD8+ T cell–mediated acute graft-versus-host disease

2002 • 172 citations

Tumor lysate-pulsed dendritic cells can elicit an effective antitumor immune response during early lymphoid recovery

2002 • 171 citations

Dose response and factors related to interstitial pneumonitis after bone marrow transplant

2005 • 156 citations

Reconstitution of EBV-Specific T Cell Immunity in Solid Organ Transplant Recipients

1998 • 155 citations

Thymic Selection Generates a Large T Cell Pool Recognizing a Self-Peptide in Humans

2002 • 153 citations

Supernatural T cells: genetic modification of T cells for cancer therapy

2005 • 149 citations

Cooperation of Human Tumor-Reactive CD4+ and CD8+ T Cells after Redirection of Their Specificity by a High-Affinity p53A2.1-Specific TCR

2005 • 148 citations

Development of antitumor immune responses in reconstituted lymphopenic hosts.

2002 • 136 citations

Transient increase in circulating donor leukocytes after allogeneic transfusions in immunocompetent recipients compatible with donor cell proliferation

1995 • 132 citations

Recognition of Fresh Human Tumor by Human Peripheral Blood Lymphocytes Transduced with a Bicistronic Retroviral Vector Encoding a Murine Anti-p53 TCR

2005 • 124 citations

Homeostatic Expansion Occurs Independently of Costimulatory Signals

2001 • 124 citations

Expression of passively transferred immunity against an established tumor depends on generation of cytolytic T cells in recipient. Inhibition by suppressor T cells.

1983 • 123 citations

Interleukin-2-Dependent Mechanisms of Tolerance and Immunity In Vivo

2006 • 119 citations

Lethal pulmonary complications significantly correlate with individually assessed mean lung dose in patients with hematologic malignancies treated with total body irradiation

2002 • 111 citations

Less is more: lymphodepletion followed by hematopoietic stem cell transplant augments adoptive T-cell-based anti-tumor immunotherapy

2005 • 110 citations

Human skin cells support thymus-independent T cell development

2005 • 95 citations

Predictive Value of Pulmonary Function Tests before Marrow Transplantation

1992 • 93 citations

Adoptive transfer of allogeneic Epstein–Barr virus (EBV)-specific cytotoxic T cells with in vitro antitumor activity boostsLMP2-specific immune response in a patient with EBV-related nasopharyngeal carcinoma

2003 • 85 citations

Lack of tumor recognition by hTERT peptide 540-548-specific CD8+ T cells from melanoma patients reveals inefficient antigen processing

2001 • 85 citations

Anti‐tumor T cell response and protective immunity in mice that received sublethal irradiation and immune reconstitution

2003 • 85 citations

Combination Chemotherapy and Radiation of Human Squamous Cell Carcinoma of the Head and Neck Augments CTL-Mediated Lysis

2006 • 85 citations

Detection of circulating donor white blood cells in patients receiving multiple transfusions

1992 • 82 citations

Comparison of fractionated to single-dose total body irradiation in conditioning canine littermates for DLA-identical marrow grafts

1989 • 75 citations

Adoptive transfer of allogeneic cytotoxic T lymphocytes equipped with a HLA-A2 restricted MART-1 T-cell receptor: a phase I trial in metastatic melanoma.

2006 • 72 citations

Evaluation of interleukin-2 administered by continuous infusion in patients with metastatic melanoma

1996 • 72 citations

Programming CD8+ T cells for effective immunotherapy

2006 • 70 citations

Host Lymphodepletion Augments T Cell Adoptive Immunotherapy through Enhanced Intratumoral Proliferation of Effector Cells

2005 • 69 citations

Use of B cell-bound HLA-A2 class I monomers to generate high-avidity, allo-restricted CTLs against the leukemia-associated protein Wilms tumor antigen

2004 • 62 citations

CTLA-4 dysregulation of self/tumor-reactive CD8+ T-cell function is CD4+ T-cell dependent

2006 • 60 citations

The structural basis of T‐cell allorecognition

2004 • 59 citations

Feasibility of Allogeneic Hematopoietic Stem Cell Transplantation for Autoimmune Disease: Position Statement from a National Institute of Allergy and Infectious Diseases and National Cancer Institute–Sponsored International Workshop, Bethesda, MD, March 12 and 13, 2005

2005 • 58 citations

Prediction and prevention of transplant-related mortality from pulmonary causes after total body irradiation and allogeneic stem cell transplantation

2005 • 56 citations

Treatment of relapsed Hodgkin’s disease using EBV-specific cytotoxic T cells

1998 • 51 citations

Fractionated versus single-dose total body irradiation at low and high dose rates to condition canine littermates for DLA-identical marrow grafts

1994 • 50 citations

Mature CD4+ T Cells Perceive a Positively Selecting Class II MHC/Peptide Complex in the Periphery

2000 • 49 citations

Radiation-associated pneumonitis following autologous stem cell transplantation: predictive factors, disease characteristics and treatment outcomes

2001 • 42 citations

Chimerism and clinical outcomes of 110 recipients of unrelated donor bone marrow transplants who underwent conditioning with low-dose, single-exposure total body irradiation and cyclophosphamide

2004 • 40 citations

Outcomes of adults with acute myelogenous leukemia in remission given 550 cGy of single-exposure total body irradiation, cyclophosphamide, and unrelated donor bone marrow transplants

2004 • 40 citations

Radiation-induced Protein Loss into the Gastrointestinal Tract

1966 • 40 citations

Sequential Expression of Adhesion and Costimulatory Molecules in Graft-versus-Host Disease Target Organs after Murine Bone Marrow Transplantation across Minor Histocompatibility Antigen Barriers

2005 • 36 citations

Investigation of Peptide Involvement in T Cell Allorecognition Using Recombinant HLA Class I Multimers

2005 • 30 citations

Intensification of the stem cell transplant induction regimen results in increased treatment-related mortality without improved outcome in multiple myeloma

1999 • 29 citations

Low-dose (550 cGy), single-exposure total body irradiation and cyclophosphamide: Consistent, durable engraftment of related-donor peripheral blood stem cells with low treatment-related mortality and fatal organ toxicity

2002 • 28 citations

The rationale behind autologous autoimmune hematopoietic stem cell transplant conditioning regimens: concerns over the use of total-body irradiation in systemic sclerosis

2004 • 28 citations

Ex Vivo Characterization of Allo-MHC-Restricted T Cells Specific for a Single MHC-Peptide Complex

2006 • 26 citations

Designing TCR for Cancer Immunotherapy

2004 • 20 citations

Functional analysis of HLA-A*0201/Melan-A peptide multimer+ CD8+ T cells isolated from an HLA-A*0201- donor: exploring tumor antigen allorestricted recognition.

2002 • 16 citations

Lymphocyte Depletion as a Barrier to Immunological Tolerance

2004 • 14 citations

Significance of bacterial flora in abdominal irradiation-induced inhibition of lung metastases.

1988 • 8 citations

Adoptive immunotherapy of hormone-refractory, stage D2 prostate cancer using ex vivo activated autologous T cells (autolymphocyte therapy): results from a pilot study.

1993 • 7 citations