Recombinant Toxins for Cancer Treatment

Protein engineering of antibody binding sites: recovery of specific activity in an anti-digoxin single-chain Fv analogue produced in Escherichia coli.

1988 • 1,536 citations

Single-Chain Antigen-Binding Proteins

1988 • 1,450 citations

Assembly of a Functional Immunoglobulin F _v Fragment in Escherichia coli

1988 • 973 citations

Diphtheria Toxin

1977 • 780 citations

One molecule of diphtheria toxin fragment a introduced into a cell can kill the cell

1978 • 744 citations

B4, a human B lymphocyte-associated antigen expressed on normal, mitogen-activated, and malignant B lymphocytes.

1983 • 517 citations

Structure of exotoxin A of Pseudomonas aeruginosa at 3.0-Angstrom resolution.

1986 • 517 citations

Functional domains of pseudomonas exotoxin identified by deletion analysis of the gene expressed in E. coli

1987 • 449 citations

Epidermal-Growth-Factor-Dependent Transformation by a Human EGF Receptor Proto-Oncogene

1987 • 448 citations

A recombinant immunotoxin consisting of two antibody variable domains fused to Pseudomonas exotoxin

1989 • 420 citations

Human squamous cell lung cancers express increased epidermal growth factor receptors.

1984 • 371 citations

Redesigning Nature's Poisons to Create Anti-Tumor Reagents

1987 • 329 citations

Phase I immunotoxin trial in patients with B-cell lymphoma.

1991 • 289 citations

Immunotoxins: hybrid molecules of monoclonal antibodies and a toxin subunit specifically kill tumour cells

1981 • 253 citations

Diphtheria toxin receptor binding domain substitution with interleukin-2: genetic construction and properties of a diphtheria toxin-related interleukin-2 fusion protein

1987 • 236 citations

Processing of Pseudomonas exotoxin by a cellular protease results in the generation of a 37,000-Da toxin fragment that is translocated to the cytosol

1990 • 233 citations

Immunotoxins

1986 • 230 citations

B3(Fv)-PE38KDEL, a single-chain immunotoxin that causes complete regression of a human carcinoma in mice.

1991 • 219 citations

Receptor-mediated endocytosis of epidermal growth factor by rat hepatocytes: receptor pathway.

1986 • 217 citations

Therapy of patients with malignant melanoma using a monoclonal antimelanoma antibody-ricin A chain immunotoxin.

1987 • 212 citations

Functional Analysis of Domains II, Ib, and III of Pseudomonas exotoxin

1989 • 193 citations

Definition by monoclonal antibodies of a repertoire of epitopes on carcinoembryonic antigen differentially expressed in human colon carcinomas versus normal adult tissues.

1985 • 177 citations

Receptor-mediated internalization of pseudomonas toxin by mouse fibroblasts

1980 • 176 citations

Mutations in Diphtheria Toxin Separate Binding from Entry and Amplify Immunotoxin Selectivity

1987 • 173 citations

Targeted Toxin Therapy for the Treatment of Cancer

1989 • 158 citations

A rapid method of cloning functional variable-region antibody genes in Escherichia coli as single-chain immunotoxins.

1990 • 156 citations

Activity of immunotoxins constructed with modified Pseudomonas exotoxin A lacking the cell recognition domain.

1988 • 147 citations

Antigens associated with a human lung adenocarcinoma defined by monoclonal antibodies.

1984 • 142 citations

Characterization of monoclonal antibodies B1 and B3 that react with mucinous adenocarcinomas.

1991 • 140 citations

Cytotoxic activity of an interleukin 2-Pseudomonas exotoxin chimeric protein produced in Escherichia coli.

1988 • 133 citations

Pseudomonas exotoxin: chimeric toxins

1989 • 129 citations

Phase I Study of an Anti-Breast Cancer Immunotoxin by Continuous Infusion: Report of a Targeted Toxic Effect Not Predicted by Animal Studies

1989 • 124 citations

Clinical evaluation of intraperitoneal Pseudomonas exotoxin immunoconjugate OVB3-PE in patients with ovarian cancer.

1991 • 124 citations

Phase I evaluation of an anti-breast carcinoma monoclonal antibody 260F9-recombinant ricin A chain immunoconjugate.

1989 • 122 citations

In vivo therapy of a murine B cell tumor (BCL1) using antibody-ricin A chain immunotoxins.

1982 • 122 citations

How protein toxins enter and kill cells

1988 • 122 citations

Evaluation of ricin A chain-containing immunotoxins directed against CD19 and CD22 antigens on normal and malignant human B-cells as potential reagents for in vivo therapy.

1988 • 116 citations

TRANSMEMBRANE TRANSPORT OF DIPHTHERIA TOXIN, RELATED TOXINS, AND COLICINS

1986 • 115 citations

Ricin A-chain containing immunotoxins directed against different epitopes on the CD2 molecule differ in their ability to kill normal and malignant T cells.

1988 • 95 citations

Blockade of the galactose‐binding sites of ricin by its linkage to antibody

1984 • 93 citations

Pseudomonas exotoxin-anti-TAC. Cell-specific immunotoxin active against cells expressing the human T cell growth factor receptor.

1984 • 92 citations

Expression of soluble and fully functional ricin A chain in Escherichia coli is temperature-sensitive.

1988 • 92 citations

Tissue distribution of breast cancer-associated antigens defined by monoclonal antibodies.

1985 • 88 citations

Phase I study of monoclonal antibody-ricin A chain immunotoxin XomaZyme-791 in patients with metastatic colon cancer.

1989 • 88 citations

Autologous bone marrow transplantation in high-risk remission T-lineage acute lymphoblastic leukemia using immunotoxins plus 4- hydroperoxycyclophosphamide for marrow purging

1990 • 88 citations

Mutational analysis of domain I of Pseudomonas exotoxin. Mutations in domain I of Pseudomonas exotoxin which reduce cell binding and animal toxicity.

1988 • 87 citations

The galactose-binding sites of the cytotoxic lectin ricin can be chemically blocked in high yield with reactive ligands prepared by chemical modification of glycopeptides containing triantennary N-linked oligosaccharides

1991 • 85 citations

Cytotoxic activity of an interleukin 6-Pseudomonas exotoxin fusion protein on human myeloma cells.

1988 • 82 citations

Single-chain immunotoxins directed at the human transferrin receptor containing Pseudomonas exotoxin A or diphtheria toxin: anti-TFR(Fv)-PE40 and DT388-anti-TFR(Fv).

1991 • 81 citations

Cellular processing of the interleukin-2 fusion toxin DAB486-IL-2 and efficient delivery of diphtheria fragment A to the cytosol of target cells requires Arg194

1990 • 81 citations

A recombinant single-chain immunotoxin composed of anti-Tac variable regions and a truncated diphtheria toxin.

1990 • 80 citations

Autologous bone marrow transplantation in high-risk remission T-lineage acute lymphoblastic leukemia using immunotoxins plus 4- hydroperoxycyclophosphamide for marrow purging

1990 • 80 citations

The recombinant immunotoxin anti-Tac(Fv)-Pseudomonas exotoxin 40 is cytotoxic toward peripheral blood malignant cells from patients with adult T-cell leukemia.

1990 • 80 citations

Antitumor activity in mice of an immunotoxin made with anti-transferrin receptor and a recombinant form of Pseudomonas exotoxin.

1989 • 76 citations

Cloned fragment of diphtheria toxin linked to T cell-specific antibody identifies regions of B chain active in cell entry.

1986 • 76 citations

Anti-tumor activities of immunotoxins made of monoclonal antibody B3 and various forms of Pseudomonas exotoxin.

1991 • 70 citations

Transforming growth factor alpha-Pseudomonas exotoxin fusion protein prolongs survival of nude mice bearing tumor xenografts.

1990 • 69 citations

A phase I study of T101-ricin A chain immunotoxin in refractory chronic lymphocytic leukemia.

1988 • 69 citations

Antitumor activity of intraperitoneal immunotoxins in a nude mouse model of human malignant mesothelioma.

1987 • 67 citations

Antitumor activity of a transforming growth factor alpha-Pseudomonas exotoxin fusion protein (TGF-alpha-PE40).

1991 • 66 citations

Pseudomonas exotoxin coupled to a monoclonal antibody against ovarian cancer inhibits the growth of human ovarian cancer cells in a mouse model.

1987 • 64 citations

Epidermal growth factor receptor expression in 72 meningiomas

1990 • 63 citations

Epidermal Growth Factor in the Normal and Neoplastic Kidney and Bladder

1988 • 60 citations

Antitumor activity of an immunotoxin in a nude mouse model of human ovarian cancer.

1987 • 60 citations

Cytotoxicity of interleukin 2-toxin toward lymphocytes from patients with adult T-cell leukemia.

1989 • 56 citations

Cytotoxicity of a recombinant ricin‐A‐chain fusion protein containing a proteolytically‐cleavable spacer sequence

1990 • 54 citations

Cytotoxicity against human tumor cells mediated by the conjugate of anti-epidermal growth factor receptor monoclonal antibody to recombinant ricin A chain.

1989 • 54 citations

In vitro endoproteolytic cleavage of castor bean lectin presursors

1985 • 49 citations

Sequential effects of interleukin 2-diphtheria toxin fusion protein on T-cell activation.

1989 • 49 citations

Oncogene‐associated tumor antigens as targets for immunotherapy

1989 • 48 citations

Cytotoxic activity of a recombinant fusion protein between interleukin 4 and Pseudomonas exotoxin.

1989 • 42 citations

Antitumor effects of interleukin 6-Pseudomonas exotoxin chimeric molecules against the human hepatocellular carcinoma, PLC/PRF/5 in mice.

1991 • 36 citations

Humoral immune responses to XMMCO-791-RTA immunotoxin in colorectal cancer patients.

1989 • 35 citations

Cytotoxic activity of chimeric proteins composed of acidic fibroblast growth factor and Pseudomonas exotoxin on a variety of cell types

1991 • 31 citations

Isolation and characterization of Pseudomonas aeruginosa exotoxin A binding glycoprotein from mouse LM cells

1991 • 30 citations

Cytotoxic activity of a recombinant fusion protein between insulin-like growth factor I and Pseudomonas exotoxin.

1991 • 29 citations

Intracellular routing rather than cross-linking or rate of internalization determines the potency of immunotoxins directed against different epitopes of sIgD on murine B cells

1991 • 27 citations

Diphtheria toxin-related alpha-melanocyte-stimulating hormone fusion toxin. Internal in-frame deletion from Thr387 to His485 results in the formation of a highly potent fusion toxin which is resistant to proteolytic degradation

1991 • 25 citations

Cytotoxicity of IL6-PE40 and derivatives on tumor cells expressing a range of interleukin 6 receptor levels.

1990 • 25 citations

IL-2-PE40 prevents the development of tumors in mice injected with IL-2 receptor expressing EL4 transfectant tumor cells.

1990 • 25 citations

IL-2-PE40 is cytotoxic for activated T lymphocytes expressing IL-2 receptors.

1988 • 24 citations

Diphtheria-related peptide hormone gene fusions: A molecular genetic approach to chimeric toxin development

1988 • 20 citations

Pseudomonas exotoxin — Immunotoxins

1988 • 20 citations

The interleukin-2 receptor on malignant cells: A target for diagnosis and therapy

1986 • 17 citations

Treatment of leukemia patients with T101 ricin A chain immunotoxins

1988 • 13 citations

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