Transforming growth factor alpha-Pseudomonas exotoxin fusion protein prolongs survival of nude mice bearing tumor xenografts.

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1983 • 52,849 citations

Statistical Methods for Survival Data Analysis.

1993 • 2,960 citations

In Vitro Cultivation of Human Tumors: Establishment of Cell Lines Derived From a Series of Solid Tumors2

1973 • 2,213 citations

Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin

1985 • 1,523 citations

Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification.

1987 • 843 citations

A native 170,000 epidermal growth factor receptor-kinase complex from shed plasma membrane vesicles.

1982 • 788 citations

Nerve growth factor receptors on human melanoma cells in culture.

1977 • 670 citations

NAD-dependent inhibition of protein synthesis by Pseudomonas aeruginosa toxin,.

1975 • 619 citations

Visualization by fluorescence of the binding and internalization of epidermal growth factor in human carcinoma cells A-431.

1978 • 578 citations

Structure of exotoxin A of Pseudomonas aeruginosa at 3.0-Angstrom resolution.

1986 • 517 citations

Functional domains of pseudomonas exotoxin identified by deletion analysis of the gene expressed in E. coli

1987 • 449 citations

Cloning, nucleotide sequence, and expression in Escherichia coli of the exotoxin A structural gene of Pseudomonas aeruginosa.

1984 • 286 citations

Adenovirus-induced release of epidermal growth factor and pseudomonas toxin into the cytosol of KB cells during receptor-mediated endocytosis

1983 • 256 citations

Enzymatically active peptide from the adenosine diphosphate-ribosylating toxin of Pseudomonas aeruginosa

1977 • 196 citations

Functional Analysis of Domains II, Ib, and III of Pseudomonas exotoxin

1989 • 193 citations

Epidermal growth factor receptors in human breast cancer

1984 • 190 citations

Activity of a recombinant fusion protein between transforming growth factor type alpha and Pseudomonas toxin.

1987 • 178 citations

Activity of immunotoxins constructed with modified Pseudomonas exotoxin A lacking the cell recognition domain.

1988 • 147 citations

High incidence of egf receptor hyperproduction in esophageal squamous‐cell carcinomas

1987 • 142 citations

Immunohistology of the Antigenic Pattern of a Continuous Cell Line From a Human Colon Tumor

1975 • 142 citations

Cytotoxic activity of an interleukin 2-Pseudomonas exotoxin chimeric protein produced in Escherichia coli.

1988 • 133 citations

Evidence for increased epidermal growth factor receptors in human sarcomas

1985 • 113 citations

Cytotoxic activity of an interleukin 6-Pseudomonas exotoxin fusion protein on human myeloma cells.

1988 • 82 citations

Kinetic Analysis of In Vivo Receptor-Dependent Binding of Human Epidermal Growth Factor by Rat Tissues

1988 • 76 citations

Cytotoxic activities of a fusion protein comprised of TGFα and Pseudomonas exotoxin

1989 • 71 citations

Verapamil enhances the toxicity of conjugates of epidermal growth factor with Pseudomonas exotoxin and antitransferrin receptor with pseudomonas exotoxin

1984 • 57 citations

Structure-function analysis of synthetic and recombinant derivatives of transforming growth factor alpha.

1988 • 57 citations

Cardiac allograft survival in mice treated with IL-2-PE40.

1989 • 51 citations

Cytotoxic activity of a recombinant fusion protein between interleukin 4 and Pseudomonas exotoxin.

1989 • 42 citations

Epidermal growth factor receptor binding is affected by structural determinants in the toxin domain of transforming growth factor-alpha-Pseudomonas exotoxin fusion proteins.

1989 • 30 citations

Binding of human epidermal growth factor to tissue homogenates of the rat.

1987 • 22 citations

Isolation of multiple biologically and chemically diverse species of epidermal growth factor

1987 • 20 citations

Biodistribution of radioactive epidermal growth factor in normal and tumor bearing mice.

1989 • 10 citations

Epidermal Growth Factor Receptor Binding Is Affected by Structural Determinants in the Toxin Domain of Transforming Growth Factor-Alpha-Pseudomonas Exotoxin Fusion Proteins

1989 • 5 citations