Cytotoxicity against human tumor cells mediated by the conjugate of anti-epidermal growth factor receptor monoclonal antibody to recombinant ricin A chain.

The mechanism of action of ricin and related toxic lectins on eukaryotic ribosomes. The site and the characteristics of the modification in 28 S ribosomal RNA caused by the toxins.

1987 • 1,153 citations

Synthesis of messenger RNAs for transforming growth factors alpha and beta and the epidermal growth factor receptor by human tumors.

1987 • 895 citations

Growth stimulation of A431 cells by epidermal growth factor: identification of high-affinity receptors for epidermal growth factor by an anti-receptor monoclonal antibody.

1983 • 792 citations

Monoclonal anti-epidermal growth factor receptor antibodies which are inhibitors of epidermal growth factor binding and antagonists of epidermal growth factor binding and antagonists of epidermal growth factor-stimulated tyrosine protein kinase activity.

1984 • 467 citations

Biological effects in vitro of monoclonal antibodies to human epidermal growth factor receptors.

1983 • 456 citations

Mechanism of action of the toxic lectins abrin and ricin

1974 • 443 citations

Immunotherapy of Cancer: Regression of Intradermal Tumors and Prevention of Growth of Lymph Node Metastases After Intralesional Injection of Living <italic>Mycobacterium bovis</italic>

1972 • 355 citations

MDA-468, a human breast cancer cell line with a high number of epidermal growth factor (EGF) receptors, has an amplified EGF receptor gene and is growth inhibited by EGF

1985 • 332 citations

Redesigning Nature's Poisons to Create Anti-Tumor Reagents

1987 • 329 citations

Immunotoxins: A New Approach to Cancer Therapy

1983 • 282 citations

Epidermal growth factor inhibits growth of A431 human epidermoid carcinoma in serum-free cell culture.

1982 • 280 citations

Growth-inhibitory effects of epidermal growth factor and overexpression of its receptors on human squamous cell carcinomas in culture.

1986 • 252 citations

Monoclonal antibody against epidermal growth factor receptor is internalized without stimulating receptor phosphorylation.

1986 • 250 citations

Relation of epidermal growth factor receptor concentration to growth of human epidermoid carcinoma A431 cells.

1984 • 245 citations

Characterization of epidermal growth factor receptor and action on human breast cancer cells in culture.

1984 • 201 citations

Immunotoxins: Hybrid Molecules Combining High Specificity and Potent Cytotoxicity

1982 • 181 citations

Improved antitumor effects of immunotoxins prepared with deglycosylated ricin A-chain and hindered disulfide linkages.

1988 • 155 citations

Basic principles and applications of monoclonal antibodies in the management of carcinomas: the Richard and Hinda Rosenthal Foundation award lecture.

1986 • 148 citations

Effect of chemical deglycosylation of ricin A chain on the in vivo fate and cytotoxic activity of an immunotoxin composed of ricin A chain and anti-Thy 1.1 antibody.

1987 • 134 citations

Rates of different steps involved in the inhibition of protein synthesis by the toxic lectins abrin and ricin.

1976 • 124 citations

Modification of the carbohydrate in ricin with metaperiodate — cyanoborohydride mixtures

1985 • 117 citations

Study of the plasma clearance of antibody – ricin‐A‐chain immunotoxins

1986 • 116 citations

Human melanoma cells can be killed in vitro by an immunotoxin specific for melanoma‐associated antigen p97

1982 • 116 citations

Influence of antibody isotype on passive serotherapy of lymphoma.

1985 • 112 citations

Mechanism of antitumor activity in mice for anti-epidermal growth factor receptor monoclonal antibodies with different isotypes.

1986 • 106 citations

Direct Determinations of Plasma, Cell, and Organ-Blood Volumes in Normal and Hypervolemic Mice

1950 • 101 citations

Expression of soluble and fully functional ricin A chain in Escherichia coli is temperature-sensitive.

1988 • 92 citations

JANA: A new iterative polyexponential curve stripping program

1985 • 83 citations

Antitumor activity of intraperitoneal immunotoxins in a nude mouse model of human malignant mesothelioma.

1987 • 67 citations

Pharmacokinetics of tumor-reactive immunotoxins in tumor-bearing mice: effect of antibody valency and deglycosylation of the ricin A chain on clearance and tumor localization.

1988 • 65 citations

Monoclonal antibodies: potential applications to the treatment of cancer.

1986 • 61 citations

EGF induces cell cycle arrest of A431 human epidermoid carcinoma cells

1986 • 58 citations

Whole ricin and recombinant ricin A chain idiotype-specific immunotoxins for therapy of the guinea pig L2C B cell leukemia.

1987 • 39 citations

Hypothesis: Macrophages as Effector Cells For Human Tumor Destruction Mediated by Monoclonal Antibody

1983 • 37 citations

Complete suppression of in vivo growth of human leukemia cells by specific immunotoxins: nude mouse models.

1987 • 34 citations

Immunotoxins to the murine transferrin receptor: intracavitary therapy of mice bearing syngeneic peritoneal tumors.

1987 • 26 citations

Effects of epidermal growth factor on transferrin receptor phosphorylation and surface expression in malignant epithelial cells

1987 • 21 citations

Antibody-toxin hybrids: a clinical review of their use.

1985 • 21 citations

Inhibition of human T-cell tumor growth by T101-ricin A-chain in an athymic mouse model.

1988 • 15 citations

Monoclonal antibodies against the receptor for epidermal growth factor as potential anticancer agents

1987 • 5 citations