Diphtheria-related peptide hormone gene fusions: A molecular genetic approach to chimeric toxin development

One molecule of diphtheria toxin fragment a introduced into a cell can kill the cell

1978 • 744 citations

Low and high affinity cellular receptors for interleukin 2. Implications for the level of Tac antigen.

1984 • 742 citations

The Biochemistry, Biology, and Role of Interleukin 2 in the Induction of Cytotoxic T Cell and Antibody-Forming B Cell Responses

1982 • 524 citations

Interleukin 2

1984 • 497 citations

Diphtheria toxin fragment forms large pores in phospholipid bilayer membranes.

1981 • 341 citations

Simultaneous flow cytometric analysis of human T cell activation antigen expression and DNA content.

1983 • 326 citations

Nucleotide sequence of the structural gene for diphtheria toxin carried by corynebacteriophage beta.

1983 • 307 citations

Diphtheria Toxin and Related Proteins

1973 • 285 citations

Immunotoxins: A New Approach to Cancer Therapy

1983 • 282 citations

Antibody-directed cytotoxic agents: use of monoclonal antibody to direct the action of toxin A chains to colorectal carcinoma cells.

1980 • 270 citations

The amino-acid sequence of two non-toxic mutants of diphtheria toxin: CRM45 and CRM197

1984 • 245 citations

Diphtheria toxin receptor binding domain substitution with interleukin-2: genetic construction and properties of a diphtheria toxin-related interleukin-2 fusion protein

1987 • 236 citations

Immunotoxins

1986 • 230 citations

Mutation in the Structural Gene for Diphtheria Toxin carried by Temperate Phage β

1971 • 227 citations

Interleukin 2 receptor-targeted cytotoxicity. Interleukin 2 receptor-mediated action of a diphtheria toxin-related interleukin 2 fusion protein.

1988 • 220 citations

Clones of Killer and Helper T Cells: Growth Requirements, Specificity and Retention of Function in Long‐Term Culture

1980 • 206 citations

Administration of an anti-interleukin 2 receptor monoclonal antibody prolongs cardiac allograft survival in mice.

1985 • 194 citations

Similarities between interleukin-2 receptor number and affinity on activated B and T lymphocytes

1985 • 193 citations

High-affinity receptor-mediated internalization and degradation of interleukin 2 in human T cells.

1986 • 192 citations

Only high-affinity receptors for interleukin 2 mediate internalization of ligand.

1986 • 174 citations

Binding of triton X-100 to diphtheria toxin, crossreacting material 45, and their fragments.

1976 • 139 citations

Genetic construction, expression, and melanoma-selective cytotoxicity of a diphtheria toxin-related alpha-melanocyte-stimulating hormone fusion protein.

1986 • 136 citations

Therapy with monoclonal antibody to interleukin 2 receptor spares suppressor T cells and prevents or reverses acute allograft rejection in rats.

1986 • 126 citations

Nucleotide Sequence and Expression of the Diphtheria tox 228 Gene in Escherichia coli

1983 • 120 citations

The complete nucleotide sequence of the gene coding for diphtheria toxin in the corynephage omega (tox⁺) genome

1983 • 110 citations

Subcellular distribution of various proteases in Escherichia coli.

1982 • 105 citations

Artificial hybrid protein containing a toxic protein fragment and a cell membrane receptor-binding moiety in a disulfide conjugate. II. Biochemical and biologic properties of diphtheria toxin fragment A-S-S-human placental lactogen.

1977 • 86 citations

Association of cell surface receptors for melanotropin with the Golgi region in mouse melanoma cells.

1976 • 82 citations

Chimeric toxins: Toxic, disulfide-linked conjugate of concanavalin A with fragment A from diphtheria toxin

1978 • 81 citations

Cloning, sequence determination, and expression in transfected cells of the coding sequence for the tox 176 attenuated diphtheria toxin A chain.

1987 • 78 citations

Cloned fragment of diphtheria toxin linked to T cell-specific antibody identifies regions of B chain active in cell entry.

1986 • 76 citations

Thyrotropin-releasing hormone-diphtheria toxin-related polypeptide conjugates. Potential role of the hydrophobic domain in toxin entry.

1983 • 70 citations

Lectins from Abrus precatorius and Ricinus communis. I. Immunochemical relationships between toxins and agglutinins.

1974 • 69 citations

Lectins from Abrus precatorius and Ricinus communis. II. Hybrid toxins and their interaction with chain-specific antibodies.

1974 • 61 citations

Lectins from Abrus Precatorius and Ricinus Communis

1974 • 56 citations

High-level expression of a proteolytically sensitive diphtheria toxin fragment in Escherichia coli

1987 • 55 citations

Diphtheria Toxin and Related Proteins

1973 • 51 citations

Detecting Underground Nuclear Explosions at Last ?

1971 • 49 citations

DNA relationships among some tox-bearing corynebacteriophages

1985 • 48 citations

Dual parameter flow cytometric analysis of DNA content, activation antigen expression, and T cell subset proliferation in the human mixed lymphocyte reaction.

1984 • 47 citations

Cloned Fragment A of Diphtheria Toxin Is Expressed and Secreted into the Periplasmic Space of Escherichia coli K12

1983 • 46 citations

Inhibitory effects of anti-interleukin 2 receptor and anti-L3T4 antibodies on delayed type hypersensitivity: the role of complement and epitope.

1987 • 43 citations

Molecular cloning and expression of gene fragments from corynebacteriophage beta encoding enzymatically active peptides of diphtheria toxin

1983 • 42 citations

Anti-interleukin 2 receptor antibody suppresses delayed-type hypersensitivity to foreign and syngeneic antigens.

1986 • 39 citations

Restriction map of corynebacteriophages beta c and beta vir and physical localization of the diphtheria tox operon

1981 • 37 citations

Identification of deoxyribonucleic acid restriction fragments of beta-converting corynebacteriophages that carry the gene for diphtheria toxin

1981 • 34 citations

Cloned diphtheria toxin fragment A is expressed from the tox promoter and exported to the periplasm by the SecA apparatus of Escherichia coli K12.

1983 • 24 citations

Rapid stereospecific stimulation of lymphocytic metabolism by interleukin 2.

1985 • 19 citations

Cloning and expression in Escherichia coli of three fragments of diphtheria toxin truncated within fragment B

1987 • 18 citations

The interleukin-2 receptor on malignant cells: A target for diagnosis and therapy

1986 • 17 citations

High–Level Expression of Diphtheria Toxin Peptides in Escherichia coli

1986 • 13 citations

Immunotoxins: current use and future prospects in bone marrow transplantation and cancer treatment.

1986 • 10 citations

The pure and the applied

1987 • 7 citations

Organ-Specific Binding of a Thyrotropin-Releasing Hormone-Diphtheria Toxin Complex after Intravenous Administration to Rats*

1983 • 6 citations