Single-chain immunotoxins directed at the human transferrin receptor containing Pseudomonas exotoxin A or diphtheria toxin: anti-TFR(Fv)-PE40 and DT388-anti-TFR(Fv).

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

Structure of exotoxin A of Pseudomonas aeruginosa at 3.0-Angstrom resolution.

1986 • 517 citations

Functional domains of pseudomonas exotoxin identified by deletion analysis of the gene expressed in E. coli

1987 • 449 citations

A recombinant immunotoxin consisting of two antibody variable domains fused to Pseudomonas exotoxin

1989 • 420 citations

Redesigning Nature's Poisons to Create Anti-Tumor Reagents

1987 • 329 citations

Diphtheria Toxin and Related Proteins

1973 • 285 citations

Pseudomonas exotoxin contains a specific sequence at the carboxyl terminus that is required for cytotoxicity.

1990 • 267 citations

Processing of Pseudomonas exotoxin by a cellular protease results in the generation of a 37,000-Da toxin fragment that is translocated to the cytosol

1990 • 233 citations

Characterization of a monoclonal antibody (5E9) that defines a human cell surface antigen of cell activation.

1981 • 232 citations

Activity of a recombinant fusion protein between transforming growth factor type alpha and Pseudomonas toxin.

1987 • 178 citations

Reconstitution of Diphtheria Toxin from Two Nontoxic Cross-Reacting Mutant Proteins

1972 • 177 citations

Targeted Toxin Therapy for the Treatment of Cancer

1989 • 158 citations

A rapid method of cloning functional variable-region antibody genes in Escherichia coli as single-chain immunotoxins.

1990 • 156 citations

Activity of immunotoxins constructed with modified Pseudomonas exotoxin A lacking the cell recognition domain.

1988 • 147 citations

Anti-Tac(Fv)-PE40, a single chain antibody Pseudomonas fusion protein directed at interleukin 2 receptor bearing cells.

1990 • 94 citations

Anti-transferrin receptor antibody linked to Pseudomonas exotoxin as a model immunotoxin in human ovarian carcinoma cell lines.

1985 • 91 citations

Low pH-induced release of diphtheria toxin A-fragment in Vero cells. Biochemical evidence for transfer to the cytosol.

1988 • 85 citations

A recombinant single-chain immunotoxin composed of anti-Tac variable regions and a truncated diphtheria toxin.

1990 • 80 citations

Antitumor activity in mice of an immunotoxin made with anti-transferrin receptor and a recombinant form of Pseudomonas exotoxin.

1989 • 76 citations

Localization of the diphtheria toxin receptor-binding domain to the carboxyl-terminal Mr approximately 6000 region of the toxin.

1990 • 56 citations

Translocation of Diphtheria Toxin A-fragment to the Cytosol

1989 • 47 citations

Diphtheria-related peptide hormone gene fusions: A molecular genetic approach to chimeric toxin development

1988 • 20 citations

Genetic engineering of immunotoxins

1988 • 11 citations