Development of the hematopoietic system in the mouse

Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice

1995 • 3,977 citations

The in vitro development of blastocyst-derived embryonic stem cell lines: formation of visceral yolk sac, blood islands and myocardium

1985 • 1,983 citations

High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis

1993 • 1,961 citations

AML1, the Target of Multiple Chromosomal Translocations in Human Leukemia, Is Essential for Normal Fetal Liver Hematopoiesis

1996 • 1,885 citations

Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse.

1995 • 1,782 citations

Definitive Hematopoiesis Is Autonomously Initiated by the AGM Region

1996 • 1,548 citations

A common precursor for hematopoietic and endothelial cells

1998 • 1,433 citations

An early haematopoietic defect in mice lacking the transcription factor GATA-2

1994 • 1,412 citations

Vasculogenesis

1995 • 1,344 citations

Identification and isolation of endothelial cells based on their increased uptake of acetylated-low density lipoprotein.

1984 • 1,249 citations

Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis.

1996 • 1,195 citations

Hereditary Anemias of the Mouse: A Review for Geneticists

1979 • 1,141 citations

A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis

1991 • 1,074 citations

Ontogeny of the Haemopoietic System: Yolk Sac Origin of In Vivo and In Vitro Colony Forming Cells in the Developing Mouse Embryo*

1970 • 1,031 citations

Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor

1995 • 1,027 citations

Defective haematopoiesis and vasculogenesis in transforming growth factor-β1 knock out mice

1995 • 1,020 citations

In vitro differentiation of embryonic stem cells

1995 • 965 citations

Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL

1995 • 961 citations

A Requirement for Flk1 in Primitive and Definitive Hematopoiesis and Vasculogenesis

1997 • 938 citations

Hematopoietic commitment during embryonic stem cell differentiation in culture.

1993 • 919 citations

Development of hematopoietic stem cell activity in the mouse embryo

1994 • 914 citations

Generation of Lymphohematopoietic Cells from Embryonic Stem Cells in Culture

1994 • 891 citations

Developmental potential and dynamic behavior of hematopoietic stem cells

1986 • 888 citations

GATA-binding transcription factors in hematopoietic cells

1992 • 845 citations

Progressive lineage analysis by cell sorting and culture identifies FLK1+VEcadherin+ cells at a diverging point of endothelial and hemopoietic lineages

1998 • 830 citations

The Biology of Hematopoietic Stem Cells

1995 • 775 citations

The T Cell Leukemia Oncoprotein SCL/tal-1 Is Essential for Development of All Hematopoietic Lineages

1996 • 746 citations

GATA-binding transcription factors in hematopoietic cells

1992 • 727 citations

flk-1, an flt-related receptor tyrosine kinase is an early marker for endothelial cell precursors

1993 • 707 citations

Vasculogenesis and angiogenesis in embryonic-stem-cell-derived embryoid bodies

1988 • 667 citations

Introduction of a selectable gene into primitive stem cells capable of long-term reconstitution of the hemopoietic system of W/W mice

1985 • 663 citations

Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders.

1996 • 635 citations

The Oncogenic Cysteine-rich LIM domain protein Rbtn2 is essential for erythroid development

1994 • 616 citations

Multiple hematopoietic lineages develop from embryonic stem (ES) cells in culture

1991 • 615 citations

A common precursor for primitive erythropoiesis and definitive haematopoiesis

1997 • 601 citations

Expression of a foreign gene in myeloid and lymphoid cells derived from multipotent haematopoietic precursors

1985 • 598 citations

Lymphoid Potential, Probed before Circulation in Mouse, Is Restricted to Caudal Intraembryonic Splanchnopleura

1996 • 591 citations

Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene.

1995 • 582 citations

Intraaortic hemopoietic cells are derived from endothelial cells during ontogeny

1998 • 577 citations

Novel insights into erythroid development revealed through in vitro differentiation of GATA-1 embryonic stem cells.

1994 • 574 citations

cloche, an early acting zebrafish gene, is required by both the endothelial and hematopoietic lineages

1995 • 545 citations

An early pre-liver intraembryonic source of CFU-S in the developing mouse

1993 • 525 citations

Expression of c-kit gene products in known cellular targets of W mutations in normal and W mutant mice--evidence for an impaired c-kit kinase in mutant mice.

1989 • 495 citations

Embryonic stem cells differentiate in vitro to endothelial cells through successive maturation steps

1996 • 479 citations

Lhx2, a LIM homeobox gene, is required for eye, forebrain, and definitive erythrocyte development

1997 • 478 citations

Evidence for Involvement of Activin A and Bone Morphogenetic Protein 4 in Mammalian Mesoderm and Hematopoietic Development

1995 • 464 citations

Studies on the origin of blood vessels and of red corpuscles as seen in the living blastoderm of the chick during the second day of incubation

1920 • 457 citations

Differential effects of an erythropoietin receptor gene disruption on primitive and definitive erythropoiesis.

1996 • 439 citations

Characterization of Definitive Lymphohematopoietic Stem Cells in the Day 9 Murine Yolk Sac

1997 • 438 citations

The SCL gene specifies haemangioblast development from early mesoderm

1998 • 430 citations

Ligand-dependent development of the endothelial and hemopoietic lineages from embryonic mesodermal cells expressing vascular endothelial growth factor receptor 2

1997 • 412 citations

On the origin of haemopoietic stem cells in the avian embryo: an experimental approach

1975 • 399 citations

Para-aortic splanchnopleura from early mouse embryos contains B1a cell progenitors

1993 • 392 citations

In Vitro Generation of Lymphohematopoietic Cells from Endothelial Cells Purified from Murine Embryos

1998 • 372 citations

Emergence of multipotent hemopoietic cells in the yolk sac and paraaortic splanchnopleura in mouse embryos, beginning at 8.5 days postcoitus.

1995 • 367 citations

Flk-1 expression defines a population of early embryonic hematopoietic precursors

1990 • 363 citations

The development in vitro of the blood of the early chick embryo

1932 • 336 citations

Hematopoietic development of embryonic stem cells in vitro: cytokine and receptor gene expression.

1991 • 332 citations

Cellular and developmental properties of fetal hematopoietic stem cells

1990 • 317 citations

Critical Role of the TIE2 Endothelial Cell Receptor in the Development of Definitive Hematopoiesis

1998 • 314 citations

The SCL/TAL-1 gene is expressed in progenitors of both the hematopoietic and vascular systems during embryogenesis

1994 • 295 citations

B cell ontogeny in murine embryo studied by a culture system with the monolayer of a stromal cell clone, ST2: B cell progenitor develops first in the embryonal body rather than in the yolk sac.

1988 • 292 citations

Hematopoietic Commitment During Embryonic Stem Cell Differentiation in Culture

1993 • 273 citations

The sialomucin CD34 is expressed on hematopoietic cells and blood vessels during murine development

1995 • 240 citations

Embryonic stem cell-derived cystic embryoid bodies form vascular channels: an in vitro model of blood vessel development

1992 • 239 citations

Qualitative and quantitative aspects of haematopoietic cell development in the mammalian embryo

1998 • 193 citations

Hemoglobin ontogeny during normal mouse fetal development.

1979 • 177 citations

Properties of the earliest clonogenic hemopoietic precursors to appear in the developing murine yolk sac.

1986 • 174 citations

Chromosome Marker Studies in the Irradiated Chick Embryo

1967 • 153 citations

PECAM-1: Its Expression and Function as a Cell Adhesion Molecule on Hemopoietic and Endothelial Cells

1995 • 152 citations

BMP-4-responsive regulation of dorsal–ventral patterning by the homeobox protein Mix.1

1996 • 152 citations

Development of the mouse hematopoietic system

1968 • 152 citations

Dual contribution of embryonic ventral blood island and dorsal lateral plate mesoderm during ontogeny of hemopoietic cells in Xenopus laevis.

1983 • 144 citations

Initiation of Murine Embryonic Erythropoiesis: A Spatial Analysis

1997 • 144 citations

Bipotential Primitive-Definitive Hematopoietic Progenitors in the Vertebrate Embryo

1997 • 140 citations

Globin Gene Expression Is Reprogrammed in Chimeras Generated by Injecting Adult Hematopoietic Stem Cells into Mouse Blastocysts

1998 • 129 citations

ES cells have only a limited lymphopoietic potential after adoptive transfer into mouse recipients

1993 • 128 citations

An in vitro globin gene switching model based on differentiated embryonic stem cells.

1990 • 125 citations

Embryonic Origin of the Mouse Macrophage

1972 • 124 citations

Hematopoietic-Specific Genes Are Not Induced During In Vitro Differentiation of scl-Null Embryonic Stem Cells

1997 • 120 citations

Regulation offlt-1 expression during mouse embryogenesis suggests a role in the establishment of vascular endothelium

1996 • 119 citations

Cooperative Effects of Growth Factors Involved in the Induction of Hematopoietic Mesoderm

1998 • 110 citations

In vitro generation of lymphoid precursors from embryonic stem cells.

1994 • 108 citations

Differentiation and characterization of B-cell precursors detected in the yolk sac and embryo body of embryos beginning at the 10- to 12-somite stage.

1993 • 104 citations

A limited temporal window for the derivation of multilineage repopulating hematopoietic progenitors during embryonal stem cell differentiation in vitro

1996 • 99 citations

Early fetal hematopoietic development from in vitro differentiated embryonic stem cells.

1991 • 94 citations

GENETICS OF ERYTHROPOIESIS: Induced Mutations in Mice and Zebrafish

1997 • 93 citations

Identification of a Fetal Hematopoietic Precursor with B Cell, T Cell, and Macrophage Potential

1998 • 91 citations

In vitro development of murine T cells from prethymic and preliver embryonic yolk sac hematopoietic stem cells

1991 • 89 citations

Intraembryonic origin of hepatic hematopoiesis in Xenopus laevis.

1995 • 83 citations

Hemato-lymphoidin vivoreconstitution potential of subpopulations derived fromin vitrodifferentiated embryonic stem cells

1997 • 83 citations

BMP-like signals are required after the midblastula transition for blood cell development

1996 • 76 citations

Erythropoiesis and lymphopoiesis in the chick yolk-sac-embryo chimeras: contribution of yolk sac and intraembryonic stem cells

1982 • 75 citations

Overexpression of HOX11 Leads to the Immortalization of Embryonic Precursors With Both Primitive and Definitive Hematopoietic Potential

1998 • 75 citations

Hematopoietic Stem Cell Emergence in Embryonic Life: Developmental Hematology Revisited

1996 • 71 citations

At day 8-8.5 of mouse development the yolk sac, not the embryo proper, has lymphoid precursor potential in vivo and in vitro.

1993 • 60 citations

In vitro differentiation of B cells and myeloid cells from the early mouse embryo and its extraembryonic yolk sac.

1994 • 57 citations

Erythroid progenitor cells and stimulating factors during murine embryonic and fetal development.

1985 • 50 citations

Hematopoietic stem cells

1992 • 47 citations

Definitive But Not Primitive Hematopoiesis Is Impaired injumonji Mutant Mice

1999 • 46 citations

Immunophenotypic and ultrastructural heterogeneity of macrophage differentiation in bone marrow and fetal hematopoiesis of mouse in vitro and in vivo

1994 • 45 citations

Use of the Zebrafish ( Danio rerio ) to Define Hematopoiesis

1998 • 43 citations

Receptor activities for low-density lipoprotein and acetylated low-density lipoprotein in a mouse macrophage cell line (IC21) and in human monocyte-derived macrophages.

1981 • 40 citations

Different macrophage populations develop from embryonic/fetal and adult hematopoietic tissues.

1997 • 33 citations

Lineage marker-negative lymphocyte precursors derived from embryonic stem cells in vitro differentiate into mature lymphocytes in vivo

1994 • 26 citations

Ontogeny of Hematopoiesis in the Avian Embryo: A General Paradigm

1996 • 19 citations