Hematopoietic Commitment During Embryonic Stem Cell Differentiation in Culture

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells

1988 • 2,004 citations

Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence

1989 • 1,876 citations

Inhibition of pluripotential embryonic stem cell differentiation by purified polypeptides

1988 • 1,848 citations

Stem cell factor is encoded at the SI locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor

1990 • 1,448 citations

Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1

1991 • 1,321 citations

Actions of Insulin-Like Growth Factors

1985 • 1,141 citations

Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using modified cDNA expression vectors

1988 • 1,086 citations

A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis

1991 • 1,074 citations

Ontogeny of the Haemopoietic System: Yolk Sac Origin of In Vivo and In Vitro Colony Forming Cells in the Developing Mouse Embryo*

1970 • 1,031 citations

Expression pattern of the mouse T gene and its role in mesoderm formation

1990 • 854 citations

Cloning of the T gene required in mesoderm formation in the mouse

1990 • 847 citations

Germ-line transmission of genes introduced into cultured pluripotential cells by retroviral vector

1986 • 761 citations

Transmembrane form of the kit ligand growth factor is determined by alternative splicing and is missing in the SId mutant

1991 • 740 citations

Transcription of the dystrophin gene in human muscle and non-muscle tissues

1988 • 733 citations

Evidence that hematopoietic stem cells express mouse c-kit but do not depend on steel factor for their generation.

1992 • 650 citations

Molecular cloning of a cDNA encoding interleukin 11, a stromal cell-derived lymphopoietic and hematopoietic cytokine.

1990 • 649 citations

Illegitimate transcription: transcription of any gene in any cell type.

1989 • 647 citations

Multiple hematopoietic lineages develop from embryonic stem (ES) cells in culture

1991 • 615 citations

Embryonic expression of a haematopoietic growth factor encoded by the SI locus and the ligand for c-kit

1990 • 521 citations

vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells.

1989 • 514 citations

Steel locus defines new multipotent growth factor

1990 • 509 citations

Expression of c-kit gene products in known cellular targets of W mutations in normal and W mutant mice--evidence for an impaired c-kit kinase in mutant mice.

1989 • 495 citations

New light on Myc and Myb. Part II. Myb.

1990 • 487 citations

HEMOPOIETIC CELL GROWTH FACTORS AND THEIR RECEPTORS

1989 • 432 citations

Cloning of an Interleukin-3 Receptor Gene: a Member of a Distinct Receptor Gene Family

1990 • 417 citations

Cell interactions modulate embryonal carcinoma cell differentiation into parietal or visceral endoderm

1981 • 384 citations

Human GATA-3: a lineage-restricted transcription factor that regulates the expression of the T cell receptor alpha gene.

1991 • 364 citations

The gene SCL is expressed during early hematopoiesis and encodes a differentiation-related DNA-binding motif.

1989 • 363 citations

Constitutive synthesis of interleukin-3 by leukaemia cell line WEHI-3B is due to retroviral insertion near the gene

1985 • 333 citations

Hematopoietic development of embryonic stem cells in vitro: cytokine and receptor gene expression.

1991 • 332 citations

Rescue of erythroid development in gene targeted GATA–1− mouse embryonic stem cells

1992 • 258 citations

"Pure" Human Hematopoietic Progenitors: Permissive Action of Basic Fibroblast Growth Factor

1990 • 248 citations

Two distinct functional high affinity receptors for mouse interleukin-3 (IL-3).

1992 • 206 citations

Cloning and expression of a gene encoding an interleukin 3 receptor-like protein: identification of another member of the cytokine receptor gene family.

1990 • 192 citations

Expression of GATA-binding proteins during embryonic development in Xenopus laevis.

1991 • 182 citations

Hemoglobin ontogeny during normal mouse fetal development.

1979 • 177 citations

Properties of the earliest clonogenic hemopoietic precursors to appear in the developing murine yolk sac.

1986 • 174 citations

Regulated Expression of Globin Chains and the Erythroid Transcription Factor GATA-1 during Erythropoiesis in the Developing Mouse

1990 • 153 citations

The localization and synthesis of some collagen types in developing mouse embryos

1979 • 142 citations

Erythropoiesis in the Chick Embryo: The Role of Endoderm

1965 • 138 citations

Tissue specificity of alpha-fetoprotein messenger RNA expression during mouse embryogenesis.

1983 • 127 citations

An in vitro globin gene switching model based on differentiated embryonic stem cells.

1990 • 125 citations

Embryonic Origin of the Mouse Macrophage

1972 • 124 citations

Tissue interaction and the formation of the first erythroblasts of the chick embryo

1969 • 118 citations

[54] Embryonic stem cell differentiation in vitro

1993 • 116 citations

Biochemical and ultrastructural studies of proteoheparan sulfates synthesized by PYS-2, a basement membrane-producing cell line.

1982 • 116 citations

Differentiation of Rat Bone Marrow Cells Into Macrophages Under the Influence of Mouse L929 Cell Supernatant

1987 • 107 citations

Human globin chain separation by isolectric focusing

1979 • 100 citations

Interleukin-11 stimulates multiple phases of erythropoiesis in vitro

1992 • 95 citations

Hemoglobin switching during murine embryonic development: evidence for two populations of embryonic erythropoietic progenitor cells

1986 • 86 citations

Molecular cloning and chromosomal localization of the murine homolog of the human helix-loop-helix gene SCL.

1991 • 81 citations

Ultrastructural changes in mouse yolk sac associated with the initiation of vitelline circulation

1971 • 53 citations

Asynchronous synthesis of HbF and HbA during erythroblast maturation. II. Studies of G gamma, A gamma, and beta chain synthesis in individual erythroid clones from neonatal and adult BFU-E cultures

1981 • 38 citations

Mouse yolk sac and intraembryonic tissues produce factors able to elicit differentiation of erythroid burst-forming units and colony-forming units, respectively.

1984 • 33 citations

Differential expression of cellular oncogenes during rat liver development

1988 • 27 citations

The Gene for Erythropoietin Receptor Is Expressed in Multipotential Hematopoietic and Embryonal Stem Cells: Evidence for Differentiation Stage-Specific Regulation

1992 • 25 citations

Expression of c-myb in embryonal carcinoma cells and embryonal stem cells

1989 • 18 citations

Control of Hematopoietic Cell Growth Regulators during Mouse Fetal Development

1987 • 8 citations