Generation of Lymphohematopoietic Cells from Embryonic Stem Cells in Culture

Altering the Genome by Homologous Recombination

1989 • 2,021 citations

The in vitro development of blastocyst-derived embryonic stem cell lines: formation of visceral yolk sac, blood islands and myocardium

1985 • 1,983 citations

The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene

1990 • 1,763 citations

Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis

1992 • 1,285 citations

A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis

1991 • 1,074 citations

Requirement for a functional Rb-1 gene in murine development

1992 • 1,015 citations

Hematopoietic commitment during embryonic stem cell differentiation in culture.

1993 • 919 citations

Expression and function of c-kit in hemopoietic progenitor cells.

1991 • 756 citations

Cloning immunoglobulin variable domains for expression by the polymerase chain reaction.

1989 • 712 citations

Multiple hematopoietic lineages develop from embryonic stem (ES) cells in culture

1991 • 615 citations

A developmental switch in thymic lymphocyte maturation potential occurs at the level of hematopoietic stem cells

1990 • 611 citations

Monoclonal xenogeneic antibodies to murine cell surface antigens: identification of novel leukocyte differentiation antigens

1978 • 589 citations

Congenital osteoclast deficiency in osteopetrotic (op/op) mice is cured by injections of macrophage colony-stimulating factor.

1991 • 359 citations

Long-term proliferating early pre B cell lines and clones with the potential to develop to surface Ig-positive, mitogen reactive B cells in vitro and in vivo.

1991 • 335 citations

Hematopoietic development of embryonic stem cells in vitro: cytokine and receptor gene expression.

1991 • 332 citations

Organization of the constant-region gene family of the mouse immunoglobulin heavy chain

1982 • 323 citations

B cell ontogeny in murine embryo studied by a culture system with the monolayer of a stromal cell clone, ST2: B cell progenitor develops first in the embryonal body rather than in the yolk sac.

1988 • 292 citations

Involvement of the c-kit receptor in the adhesion of hematopoietic stem cells to stromal cells.

1994 • 253 citations

Interleukin 7 production and function in stromal cell-dependent B cell development.

1989 • 221 citations

Permissive role of interleukin 3 (IL‐3) in proliferation and differentiation of multipotential hemopoietic progenitors in culture

1985 • 214 citations

Stepwise progression of B lineage differentiation supported by interleukin 7 and other stromal cell molecules.

1990 • 158 citations

Macrophage lineage switching of murine early pre-B lymphoid cells expressing transduced fms genes.

1990 • 129 citations

Complete nucleotide sequence of mouse imunoglobulin μ gene and comparison with other immunoglobulin heavy chain genes

1980 • 108 citations

In vitro hemopoiesis within a microenvironment created by MC3T3‐G2/PA6 preadipocytes

1984 • 100 citations

In vitro differentiation of embryonic stem cells into lymphocyte precursors able to generate T and B lymphocytes in vivo.

1992 • 96 citations

Early fetal hematopoietic development from in vitro differentiated embryonic stem cells.

1991 • 94 citations

A stimulatory effect of recombinant murine interleukin-7 (IL-7) on B- cell colony formation and an inhibitory effect of IL-1 alpha

1989 • 78 citations

Establishment and characterization of lymphoid and myeloid mixed-cell populations from mouse late embryoid bodies, "embryonic-stem-cell fetuses".

1992 • 53 citations

Differentiation of Mouse Embryonic Stem Cells to Lympho-Hematopoietic Lineagesin Vitro

1992 • 25 citations