Overexpression of HOX11 Leads to the Immortalization of Embryonic Precursors With Both Primitive and Definitive Hematopoietic Potential

Genomic sequencing.

1984 • 8,343 citations

Purification and Characterization of Mouse Hematopoietic Stem Cells

1988 • 2,856 citations

Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor

1992 • 2,004 citations

AML1, the Target of Multiple Chromosomal Translocations in Human Leukemia, Is Essential for Normal Fetal Liver Hematopoiesis

1996 • 1,885 citations

VLA Proteins in the Integrin Family: Structures, Functions, and Their Role on Leukocytes

1990 • 1,592 citations

Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis.

1996 • 1,195 citations

Hereditary Anemias of the Mouse: A Review for Geneticists

1979 • 1,141 citations

Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using modified cDNA expression vectors

1988 • 1,086 citations

A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis

1991 • 1,074 citations

Ontogeny of the Haemopoietic System: Yolk Sac Origin of In Vivo and In Vitro Colony Forming Cells in the Developing Mouse Embryo*

1970 • 1,031 citations

Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor

1995 • 1,027 citations

In vitro differentiation of embryonic stem cells

1995 • 965 citations

Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL

1995 • 961 citations

Hematopoietic commitment during embryonic stem cell differentiation in culture.

1993 • 919 citations

Development of hematopoietic stem cell activity in the mouse embryo

1994 • 914 citations

GATA-binding transcription factors in hematopoietic cells

1992 • 845 citations

GATA-binding transcription factors in hematopoietic cells

1992 • 727 citations

Versatile retroviral vectors for potential use in gene therapy.

1994 • 690 citations

Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders.

1996 • 635 citations

A developmental switch in thymic lymphocyte maturation potential occurs at the level of hematopoietic stem cells

1990 • 611 citations

The purification and characterization of fetal liver hematopoietic stem cells.

1995 • 607 citations

Overexpression of HOXB4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivo.

1995 • 606 citations

A common precursor for primitive erythropoiesis and definitive haematopoiesis

1997 • 601 citations

Lymphoid Potential, Probed before Circulation in Mouse, Is Restricted to Caudal Intraembryonic Splanchnopleura

1996 • 591 citations

Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene.

1995 • 582 citations

Monoclonal antibodies to Pgp-1/CD44 block lympho-hemopoiesis in long-term bone marrow cultures.

1990 • 574 citations

Characterization and regulation of RB6-8C5 antigen expression on murine bone marrow cells.

1991 • 512 citations

Expression of c-kit gene products in known cellular targets of W mutations in normal and W mutant mice--evidence for an impaired c-kit kinase in mutant mice.

1989 • 495 citations

Differential effects of an erythropoietin receptor gene disruption on primitive and definitive erythropoiesis.

1996 • 439 citations

On the origin of haemopoietic stem cells in the avian embryo: an experimental approach

1975 • 399 citations

Leukaemia inhibitory factor is necessary for maintenance of haematopoietic stem cells and thymocyte stimulation

1993 • 367 citations

Emergence of multipotent hemopoietic cells in the yolk sac and paraaortic splanchnopleura in mouse embryos, beginning at 8.5 days postcoitus.

1995 • 367 citations

The gene SCL is expressed during early hematopoiesis and encodes a differentiation-related DNA-binding motif.

1989 • 363 citations

Flk-1 expression defines a population of early embryonic hematopoietic precursors

1990 • 363 citations

Hematopoietic development of embryonic stem cells in vitro: cytokine and receptor gene expression.

1991 • 332 citations

Cellular and developmental properties of fetal hematopoietic stem cells

1990 • 317 citations

A population of early fetal thymocytes expressing FcγRIIIII contains precursors of T lymphocytes and natural killer cells

1992 • 264 citations

A monoclonal antibody that recognizes B cells and B cell precursors in mice.

1981 • 260 citations

In Vitro Development of Primitive and Definitive Erythrocytes from Different Precursors

1996 • 240 citations

HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint

1997 • 195 citations

Representative in Vitro cDNA Amplification From Individual Hemopoietic Cells and Colonies

1990 • 185 citations

Hemoglobin ontogeny during normal mouse fetal development.

1979 • 177 citations

Properties of the earliest clonogenic hemopoietic precursors to appear in the developing murine yolk sac.

1986 • 174 citations

Development of the mouse hematopoietic system

1968 • 152 citations

Bipotential Primitive-Definitive Hematopoietic Progenitors in the Vertebrate Embryo

1997 • 140 citations

Overexpression of HOXB4 enhances the hematopoietic potential of embryonic stem cells differentiated in vitro

1996 • 121 citations

Conditional immortalization of mouse myelomonocytic, megakaryocytic and mast cell progenitors by the Hox-2.4 homeobox gene.

1993 • 119 citations

The HOX11 homeobox-containing gene of human leukemia immortalizes murine hematopoietic precursors.

1994 • 98 citations

Early fetal hematopoietic development from in vitro differentiated embryonic stem cells.

1991 • 94 citations

Phenotypic analysis of murine long-term hemopoietic reconstituting cells quantitated competitively in vivo and comparison with more advanced colony-forming progeny.

1995 • 90 citations

Identification of cell surface antigens present on murine hematopoietic stem cells.

1985 • 87 citations

Erythropoiesis and lymphopoiesis in the chick yolk-sac-embryo chimeras: contribution of yolk sac and intraembryonic stem cells

1982 • 75 citations

Transforming function of the HOX11/TCL3 homeobox gene.

1997 • 69 citations

Thrombopoietic potential and serial repopulating ability of murine hematopoietic stem cells constitutively expressing interleukin 11.

1996 • 62 citations

Erythroid progenitor cells and stimulating factors during murine embryonic and fetal development.

1985 • 50 citations

Molecular Basis of the Soluble and Membrane-bound Forms of the Murine Leukemia Inhibitory Factor Receptor α-Chain

1996 • 39 citations

Expression of FcγRIII defines distinct subpopulations of fetal liver B cell and myeloid precursors

1995 • 29 citations

Comparative analysis of retroviral vector expression in mouse embryonal carcinoma cells

1989 • 28 citations