ATM is a target for positive regulation by E2F-1

The regulation of E2F by pRB-family proteins

1998 • 2,297 citations

Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53

1998 • 2,034 citations

Enhanced Phosphorylation of p53 by ATM in Response to DNA Damage

1998 • 1,734 citations

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

1998 • 1,248 citations

BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures

2000 • 1,236 citations

E2F integrates cell cycle progression with DNA repair, replication, and G₂/M checkpoints

2002 • 1,102 citations

Expression of transcription factor E2F1 induces quiescent cells to enter S phase

1993 • 960 citations

Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis.

1994 • 772 citations

E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis

2001 • 747 citations

NPAT links cyclin E–Cdk2 to the regulation of replication-dependent histone gene transcription

2000 • 650 citations

The ARF/p53 pathway

2000 • 647 citations

ATM and ATR: networking cellular responses to DNA damage

2001 • 595 citations

Role for E2F in Control of Both DNA Replication and Mitotic Functions as Revealed from DNA Microarray Analysis

2001 • 587 citations

ATM associates with and phosphorylates p53: mapping the region of interaction

1998 • 494 citations

Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis

2002 • 449 citations

E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis

1995 • 422 citations

Cell cycle–regulated phosphorylation of p220^NPATby cyclin E/Cdk2 in Cajal bodies promotes histone gene transcription

2000 • 356 citations

CDC25A Phosphatase Is a Target of E2F and Is Required for Efficient E2F-Induced S Phase

1999 • 328 citations

Binding to DNA and the Retinoblastoma Gene Product Promoted by Complex Formation of Different E2F Family Members

1993 • 271 citations

Induction of DNA synthesis and apoptosis are separable functions of E2F-1.

1997 • 266 citations

E2Fs up-regulate expression of genes involved in DNA replication, DNA repair and mitosis

2002 • 263 citations

The retinoblastoma gene product protects E2F-1 from degradation by the ubiquitin-proteasome pathway.

1996 • 228 citations

Transcription Factor E2F-1 Is Upregulated in Response to DNA Damage in a Manner Analogous to That of p53

1999 • 213 citations

Multiple members of the E2F transcription factor family are the products of oncogenes.

1995 • 197 citations

The subcellular localization of E2F-4 is cell-cycle dependent

1997 • 193 citations

Cellular localisation of the ataxia-telangiectasia (ATM) gene product and discrimination between mutated and normal forms

1997 • 186 citations

The ataxia-telangiectasia gene product, a constitutively expressed nuclear protein that is not up-regulated following genome damage

1997 • 164 citations

p53 Down-Regulates CHK1 through p21 and the Retinoblastoma Protein

2001 • 163 citations

Regulation of BRCA1 Expression by the Rb-E2F Pathway

2000 • 120 citations

E2F1 Induces Phosphorylation of p53 That Is Coincident with p53 Accumulation and Apoptosis

2002 • 110 citations

p19^ARF Is Dispensable for Oncogenic Stress-Induced p53-Mediated Apoptosis and Tumor Suppression In Vivo

2002 • 86 citations

Stress signals induce transcriptionally inactive E2F-1 independently of p53 and Rb

2000 • 77 citations

ARF Differentially Modulates Apoptosis Induced by E2F1 and Myc

2002 • 70 citations

ARF Is Not Required for Apoptosis in Rb Mutant Mouse Embryos

2002 • 63 citations

Identification and characterization of a new gene physically linked to the ATM gene.

1996 • 59 citations

A gene transcribed from the bidirectional ATM promoter coding for a serine rich protein: amino acid sequence, structure and expression studies

1996 • 54 citations

Ras Induces Elevation of E2F-1 mRNA Levels

2001 • 34 citations

The Structure and Organization of the Human NPAT Gene

1997 • 18 citations