E2Fs up-regulate expression of genes involved in DNA replication, DNA repair and mitosis

Cancer Cell Cycles

1996 • 5,379 citations

The retinoblastoma protein and cell cycle control

1995 • 4,873 citations

Production of a mouse monoclonal antibody reactive with a human nuclear antigen associated with cell proliferation

1983 • 2,745 citations

The regulation of E2F by pRB-family proteins

1998 • 2,297 citations

Human DNA Repair Genes

2001 • 1,451 citations

Expression of transcription factor E2F1 induces quiescent cells to enter S phase

1993 • 960 citations

Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis.

1994 • 772 citations

E2F-1 Functions in Mice to Promote Apoptosis and Suppress Proliferation

1996 • 765 citations

Genetic Alterations of Cyclins, Cyclin-Dependent Kinases, and Cdk Inhibitors in Human Cancer

1996 • 751 citations

E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis

2001 • 747 citations

Tumor Induction and Tissue Atrophy in Mice Lacking E2F-1

1996 • 704 citations

Distinct roles for E2F proteins in cell growth control and apoptosis

1997 • 694 citations

Cellular Responses to DNA Damage

2001 • 591 citations

Role for E2F in Control of Both DNA Replication and Mitotic Functions as Revealed from DNA Microarray Analysis

2001 • 587 citations

The dynamic behavior of the APC-binding protein EB1 on the distal ends of microtubules

2000 • 401 citations

AIM-1: a mammalian midbody-associated protein required for cytokinesis

1998 • 392 citations

E2F3 activity is regulated during the cell cycle and is required for the induction of S phase

1998 • 382 citations

CDC25A Phosphatase Is a Target of E2F and Is Required for Efficient E2F-Induced S Phase

1999 • 328 citations

E2F-4 Switches from p130 to p107 and pRB in Response to Cell Cycle Reentry

1996 • 327 citations

E2f3 is critical for normal cellular proliferation

2000 • 323 citations

Deregulated Expression of E2F Family Members Induces S-Phase Entry and Overcomes p16^INK4A-Mediated Growth Suppression

1996 • 297 citations

Accumulation of cyclin B1 requires E2F and cyclin-A-dependent rearrangement of the anaphase-promoting complex

1999 • 279 citations

Binding to DNA and the Retinoblastoma Gene Product Promoted by Complex Formation of Different E2F Family Members

1993 • 271 citations

The retinoblastoma gene product protects E2F-1 from degradation by the ubiquitin-proteasome pathway.

1996 • 228 citations

Transcription Factor E2F-1 Is Upregulated in Response to DNA Damage in a Manner Analogous to That of p53

1999 • 213 citations

The subcellular localization of E2F-4 is cell-cycle dependent

1997 • 193 citations

E2F target genes and cell-cycle checkpoint control

1999 • 168 citations

In Vivo Structure of the Human cdc2 Promoter: Release of a p130–E2F-4 Complex from Sequences Immediately Upstream of the Transcription Initiation Site Coincides with Induction of cdc2 Expression

1995 • 165 citations

Late mitotic failure in mice lacking Sak, a polo-like kinase

2001 • 153 citations

Expression of Dominant-Negative Mutant DP-1 Blocks Cell Cycle Progression in G₁

1996 • 139 citations

Regulation and function of the interaction between the APC tumour suppressor protein and EB1

2000 • 121 citations

Regulation of BRCA1 Expression by the Rb-E2F Pathway

2000 • 120 citations

Regulation of expression of nuclear and mitochondrial forms of human uracil-DNA glycosylase

1998 • 103 citations

Effect of Tumor Suppressors on Cell Cycle-Regulatory Genes: RB Suppresses p34cdc2 Expression and Normal p53 Suppresses Cyclin A Expression

1994 • 102 citations

Sak, a murine protein-serine/threonine kinase that is related to the Drosophila polo kinase and involved in cell proliferation.

1994 • 100 citations

Stress signals induce transcriptionally inactive E2F-1 independently of p53 and Rb

2000 • 77 citations

Expression analysis using DNA microarrays demonstrates that E2F-1 up-regulates expression of DNA replication genes including replication protein A2

2001 • 74 citations

The Mouse Mitotic Checkpoint Gene Bub1b, a Novel Bub1 Family Member, Is Expressed in a Cell Cycle-Dependent Manner

1999 • 68 citations

Increased levels of E2F-1-dependent DNA binding activity after UV- or -irradiation

1999 • 66 citations

Promoter analysis of the human mismatch repair gene hMSH2

1998 • 43 citations

Isolation and characterization of the human mismatch repair gene hMSH2 promoter region

1996 • 23 citations

E2F-1 and a Cyclin-like DNA Repair Enzyme, Uracil-DNA Glycosylase, Provide Evidence for an Autoregulatory Mechanism for Transcription

1995 • 22 citations

Sak kinase gene structure and transcriptional regulation

2000 • 19 citations

An Amino-Terminal Fragment of SV40 T Antigen Induces Cellular DNA Synthesis in Quiescent Rat Cells

1994 • 16 citations