Ras Induces Elevation of E2F-1 mRNA Levels

Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a

1997 • 4,870 citations

The regulation of E2F by pRB-family proteins

1998 • 2,297 citations

Glycogen synthase kinase-3β regulates cyclin D1 proteolysis and subcellular localization

1998 • 2,096 citations

Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability

2000 • 1,275 citations

Cyclin D1 Expression Is Regulated Positively by the p42/p44 and Negatively by the p38/HOG Pathway

1996 • 1,203 citations

Expression of transcription factor E2F1 induces quiescent cells to enter S phase

1993 • 960 citations

Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling

1998 • 912 citations

Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties

1992 • 846 citations

p53 and E2F-1 cooperate to mediate apoptosis.

1994 • 844 citations

Transforming p21 Mutants and c-Ets-2 Activate the Cyclin D1 Promoter through Distinguishable Regions

1995 • 803 citations

The ras gene family and human carcinogenesis

1988 • 786 citations

Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis.

1994 • 772 citations

Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin-proteasome pathway.

1997 • 747 citations

Distinct roles for E2F proteins in cell growth control and apoptosis

1997 • 694 citations

Regulation of the cyclin E gene by transcription factor E2F1.

1995 • 634 citations

Ras signalling and apoptosis

1998 • 559 citations

Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis.

1994 • 515 citations

Cyclin D Expression Is Controlled Post-transcriptionally via a Phosphatidylinositol 3-Kinase/Akt-dependent Pathway

1998 • 510 citations

Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase

1994 • 493 citations

Akt, a Pleckstrin Homology Domain Containing Kinase, Is Activated Primarily by Phosphorylation

1996 • 469 citations

Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F

1997 • 468 citations

Ras Enhances Myc Protein Stability

1999 • 452 citations

Fibroblast immortality is a prerequisite for transformation by EJ c-Ha-ras oncogene

1983 • 446 citations

E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis

1995 • 422 citations

Ras Links Growth Factor Signaling to the Cell Cycle Machinery via Regulation of Cyclin D1 and the Cdk Inhibitor p27^KIP1

1997 • 409 citations

Sustained activation of extracellular-signal-regulated kinase 1 (ERK1) is required for the continued expression of cyclin D1 in G1 phase

1997 • 402 citations

Differential regulation of E2F transactivation by cyclin/cdk2 complexes.

1994 • 393 citations

BCR first exon sequences specifically activate the BCR/ABL tyrosine kinase oncogene of Philadelphia chromosome-positive human leukemias.

1991 • 392 citations

Regulation of a Senescence Checkpoint Response by the E2F1 Transcription Factor and p14^ARF Tumor Suppressor

2000 • 391 citations

Regulation of cyclin E transcription by E2Fs and retinoblastoma protein.

1996 • 387 citations

Ras signalling linked to the cell-cycle machinery by the retinoblastoma protein

1997 • 359 citations

CDC25A Phosphatase Is a Target of E2F and Is Required for Efficient E2F-Induced S Phase

1999 • 328 citations

Interaction between ubiquitin–protein ligase SCFSKP2 and E2F-1 underlies the regulation of E2F-1 degradation

1999 • 317 citations

A protein synthesis-dependent increase in E2F1 mRNA correlates with growth regulation of the dihydrofolate reductase promoter.

1993 • 315 citations

Deregulated Expression of E2F Family Members Induces S-Phase Entry and Overcomes p16^INK4A-Mediated Growth Suppression

1996 • 297 citations

Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation.

1994 • 283 citations

Binding to DNA and the Retinoblastoma Gene Product Promoted by Complex Formation of Different E2F Family Members

1993 • 271 citations

Oncogenic capacity of the E2F1 gene.

1994 • 254 citations

Raf1 interaction with Cdc25 phosphatase ties mitogenic signal transduction to cell cycle activation.

1995 • 231 citations

E2F Family Members Are Differentially Regulated by Reversible Acetylation

2000 • 230 citations

The retinoblastoma gene product protects E2F-1 from degradation by the ubiquitin-proteasome pathway.

1996 • 228 citations

Degradation of E2F by the ubiquitin-proteasome pathway: regulation by retinoblastoma family proteins and adenovirus transforming proteins.

1996 • 207 citations

Regulation of the cell cycle machinery by oncogenic ras.

1996 • 202 citations

Multiple members of the E2F transcription factor family are the products of oncogenes.

1995 • 197 citations

The subcellular localization of E2F-4 is cell-cycle dependent

1997 • 193 citations

Signalling pathways: Jack of all cascades

1996 • 186 citations

Nuclear translocation of mitogen-activated protein kinase kinase (MEK1) in response to mitogenic stimulation

1997 • 183 citations

The mechanisms of ornithine decarboxylase deregulation in c-Ha-ras oncogene-transformed NIH 3T3 cells.

1988 • 139 citations

Deregulated expression of E2F1 induces hyperplasia and cooperates with ras in skin tumor development

1998 • 138 citations

The significance of DNA and protein adducts in human biomonitoring studies

1988 • 126 citations

Multiple Ras Downstream Pathways Mediate Functional Repression of the Homeobox Gene Product TTF-1

2000 • 64 citations

VEGF mRNA is Stabilized by Ras and Tyrosine Kinase Oncogenes, as well as by UV Radiation—Evidence for Divergent Stabilization Pathways

1997 • 60 citations

Analysis of Ras-Dependent Signals That Prevent Caspase-3 Activation and Apoptosis Induced by Cytokine Deprivation in Hematopoietic Cells

2000 • 43 citations

Post-transcriptional down-regulation of expression of transcription factor NF1 by Ha-ras oncogene.

1994 • 39 citations

Role of mitogen-activated protein kinases in the induction of parathyroid hormone-related peptide.

2000 • 30 citations

A Novel Mechanism of Ha-ras Oncogene Action: Regulation of Fibronectin mRNA Levels by a Nuclear Posttranscriptional Event

1994 • 29 citations