DNA damage response pathway in radioadaptive response

SOURCES AND EFFECTS OF IONIZING RADIATION : United Nations Scientific Committee on the Effects of Atomic Radiation UNSCEAR 2000 Report to the General Assembly, with Scientific Annexes

2002 • 7,640 citations

Surfing the p53 network

2000 • 6,487 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

A Single Ataxia Telangiectasia Gene with a Product Similar to PI-3 Kinase

1995 • 2,767 citations

Cell Cycle Checkpoints: Preventing an Identity Crisis

1996 • 2,056 citations

Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53

1998 • 2,034 citations

Enhanced Phosphorylation of p53 by ATM in Response to DNA Damage

1998 • 1,734 citations

Interaction of the Fanconi Anemia Proteins and BRCA1 in a Common Pathway

2001 • 1,206 citations

Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells

1998 • 1,202 citations

Ataxia telangiectasia: a human mutation with abnormal radiation sensitivity

1975 • 984 citations

Regulation of p53 in response to DNA damage

1999 • 960 citations

The DNA-dependent protein kinase

1999 • 896 citations

P53 Binding Protein 1 (53bp1) Is an Early Participant in the Cellular Response to DNA Double-Strand Breaks

2000 • 874 citations

More than one way to die: apoptosis, necrosis and reactive oxygen damage

1999 • 850 citations

DNA damage induces phosphorylation of the amino terminus of p53

1997 • 829 citations

Adaptive Response of Human Lymphocytes to Low Concentrations of Radioactive Thymidine

1984 • 817 citations

Radiosensitivity in ataxia-telangiectasia: a new explanation.

1980 • 784 citations

DNA-dependent protein kinase catalytic subunit: A relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product

1995 • 742 citations

Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation

1999 • 690 citations

Wortmannin, a potent and selective inhibitor of phosphatidylinositol-3-kinase.

1994 • 678 citations

Twenty years of p53 research: structural and functional aspects of the p53 protein

1999 • 659 citations

The cellular response to p53: the decision between life and death

1999 • 594 citations

DNA end-joining: from yeast to man

1998 • 586 citations

Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner

1997 • 529 citations

The scid mutation in mice causes a general defect in DNA repair

1990 • 525 citations

scid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair.

1991 • 509 citations

Saccharomyces cerevisiae Ku70 potentiates illegitimate DNA double-strand break repair and serves as a barrier to error-prone DNA repair pathways.

1996 • 492 citations

DNA Ligase IV Deficiency in Mice Leads to Defective Neurogenesis and Embryonic Lethality via the p53 Pathway

2000 • 491 citations

Caenorhabditis elegans p53: Role in Apoptosis, Meiosis, and Stress Resistance

2001 • 457 citations

Mechanisms of DNA double-strand break repair and their potential to induce chromosomal aberrations

2000 • 440 citations

Wortmannin, a microbial product inhibitor of myosin light chain kinase.

1992 • 434 citations

p53-inducible Wip1 phosphatase mediates a negative feedback regulation of p38 MAPK-p53 signaling in response to UV radiation

2000 • 416 citations

p53 and its 14 kDa C-terminal domain recognize primary DNA damage in the form of insertion/deletion mismatches

1995 • 409 citations

Drosophila p53 Is a Structural and Functional Homolog of the Tumor Suppressor p53

2000 • 406 citations

The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations

2000 • 351 citations

Identification of a nonsense mutation in the carboxyl-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mouse.

1996 • 349 citations

ERKs and p38 Kinase Phosphorylate p53 Protein at Serine 15 in Response to UV Radiation

2000 • 347 citations

p53 is linked directly to homologous recombination processes via RAD51/RecA protein interaction.

1996 • 346 citations

The role of DNA double strand breaks in lonizing radiation‐induced killing of eukaryotic cells

1991 • 330 citations

A Quantitative Comparison of Potentially Lethal Damage Repair and the Rejoining of Interphase Chromosome Breaks in Low Passage Normal Human Fibroblasts

1987 • 329 citations

Signal Transduction and Cellular Radiation Responses

2000 • 321 citations

Binding of double-strand breaks in DNA by human Rad52 protein

1999 • 314 citations

The controlling role of ATM in homologous recombinational repair of DNA damage

2000 • 308 citations

Ku protein stimulates DNA end joining by mammalian DNA ligases: a direct role for Ku in repair of DNA double-strand breaks

1998 • 292 citations

Regulation of Saccharomyces Rad53 Checkpoint Kinase during Adaptation from DNA Damage–Induced G2/M Arrest

2001 • 287 citations

Identification of Genes Involved in Repair of DNA Double-Strand Breaks in Mammalian Cells

1998 • 286 citations

COMMENTARY: p⁵³ Tumor suppressor gene: from the basic research laboratory to the clinic—an abridged historical perspective

1996 • 284 citations

p38 Kinase Mediates UV-induced Phosphorylation of p53 Protein at Serine 389

1999 • 280 citations

The mei-41 gene of D. melanogaster is a structural and functional homolog of the human ataxia telangiectasia gene

1995 • 278 citations

Characterization of the Adaptive Response to Ionizing Radiation Induced by Low Doses of X Rays to Human Lymphocytes

1987 • 273 citations

Effect of ionizing radiation on DNA synthesis in ataxia telangiectasia cells

1980 • 260 citations

Recruitment of Mec1 and Ddc1 Checkpoint Proteins to Double-Strand Breaks Through Distinct Mechanisms

2001 • 253 citations

DNA Damage and Checkpoint Pathways

1998 • 251 citations

p53-dependent apoptosis suppresses radiation–induced teratogenesis

1996 • 250 citations

Radiation Mutagenesis: The Initial DNA Lesions Responsible

1995 • 238 citations

Identification and characterization of a p53 homologue in Drosophila melanogaster

2000 • 220 citations

Radioadaptive response: Efficient repair of radiation-induced DNA damage in adapted cells

1996 • 217 citations

Interaction of p53 with the Human Rad51 Protein

1997 • 212 citations

Review of repair kinetics for DNA damage induced in eukaryotic cells in vitro by ionizing radiation

1989 • 206 citations

Decline in mitogen induced proliferation of lymphocytes with increasing age.

1987 • 192 citations

The C-terminal domain of p53 recognizes DNA damaged by ionizing radiation.

1995 • 188 citations

Maintenance of genomic integrity by p53: complementary roles for activated and non-activated p53

1999 • 184 citations

Checkpoints: How to activate p53

2000 • 181 citations

Genomic Organization of the ATM Gene

1996 • 167 citations

DNA ligase IV-deficient cells are more resistant to ionizing radiation in the absence of Ku70: Implications for DNA double-strand break repair

2001 • 153 citations

Is Radiation All Bad? The Search for Adaptation

1992 • 142 citations

Elevated Recombination in Immortal Human Cells Is Mediated by HsRAD51 Recombinase

1997 • 137 citations

Associations of UBE2I with RAD52, UBL1, p53, and RAD51 Proteins in a Yeast Two-Hybrid System

1996 • 135 citations

DNA-dependent protein kinase is not required for the p53-dependent response to DNA damage

1999 • 134 citations

The contribution of homologous recombination in preserving genome integrity in mammalian cells

1999 • 132 citations

Rad52 partially substitutes for the Rad51 paralog XRCC3 in maintaining chromosomal integrity in vertebrate cells

2001 • 132 citations

Chromosomal responses to ionizing radiation reminiscent of and adaptive response in cultured Chinese hamster cells

1987 • 128 citations

The p53 Status of Chinese Hamster V79 Cells Frequently Used for Studies on DNA Damage and DNA Repair

1997 • 113 citations

On the Reaction Kinetics of the Radioadaptive Response in Cultured Mouse Cells

1995 • 109 citations

Effect of Confluent Holding on Potentially Lethal Damage Repair, Cell Cycle Progression, and Chromosomal Aberrations in Human Normal and Ataxia-Telangiectasia Fibroblasts

1985 • 104 citations

Adaptive Response to DNA-Damaging Agents

1998 • 102 citations

Altruistic Cell Suicide in Relation to Radiation Hormesis

1988 • 99 citations

Cell cycle progression in the presence of irreparable DNA damage is controlled by a Mec1- and Rad53-dependent checkpoint in budding yeast

1999 • 96 citations

Adaptive response to chromosome damage in cultured human lymphocytes primed with low doses of X-rays

1991 • 96 citations

p53 directly enhances rejoining of DNA double-strand breaks with cohesive ends in gamma-irradiated mouse fibroblasts.

1999 • 90 citations

Characterization of the DNA double strand break repair defect in scid mice.

1993 • 87 citations

Occupational Exposure to Radiation Induces an Adaptive Response in Human Lymphocytes

1995 • 87 citations

Chromosomal Adaptive Response in Human Lymphocytes

1994 • 86 citations

Precise binding of single-stranded DNA termini by human RAD52 protein

2000 • 83 citations

DNA Lesions That Signal the Induction of Radioresistance and DNA Repair in Yeast

1991 • 82 citations

Wortmannin Sensitizes Mammalian Cells to Radiation by Inhibiting the DNA-Dependent Protein Kinase-Mediated Rejoining of Double-Strand Breaks

1999 • 82 citations

The p38MAPK Inhibitor SB203580 Alleviates Ultraviolet-Induced Phosphorylation at Serine 389 but Not Serine 15 and Activation of p53

1999 • 78 citations

Wortmannin Inhibits Repair of DNA Double-Strand Breaks in Irradiated Normal Human Cells

1998 • 74 citations

Cloning and characterization of Chinese hamster p53 cDNA

1997 • 72 citations

A cytokinesis-blocked micronucleus study of the radioadaptive response of lymphocytes of individuals occupationally exposed to chronic doses of radiation

1998 • 72 citations

Coordinated Regulation of Radioadaptive Response by Protein Kinase C and p38 Mitogen-Activated Protein Kinase

1999 • 71 citations

Multiple ATM-Dependent Pathways: An Explanation for Pleiotropy

1999 • 61 citations

Increased UV‐induced SCEs but normal repair of DNA damage in p53‐deficient mouse cells

1994 • 60 citations

Induction of a cytogenetic adaptive response in germ cells of irradiated mice with very low-dose rate of chronic γ-irradiation and its biological influence on radiation-induced DNA or chromosomal damage and cell killing in their male offspring

1995 • 58 citations

Possible Causes of Variability of the Adaptive Response in Human Lymphocytes

1990 • 55 citations

Increased sequence-specific p53-DNA binding activity after DNA damage is attenuated by phorbol esters.

1993 • 54 citations

Apoptosis and the adaptive response in human lymphocytes

1999 • 53 citations

Adaptive response to ionizing radiation induced by low doses of gamma rays in human cell lines

1995 • 52 citations

Different induction of adaptive response to ionizing radiation in normal and neoplastic cells.

1999 • 49 citations

Cancer Predisposition: Ataxia–telangiectasia at the crossroads

1995 • 48 citations

Neutron-induced Adaptive Response Studied in Go Human Lymphocytes Using the Comet Assay

2001 • 47 citations

Adaptive Response to Dominant Lethality of Mature (Class A) and Immature (Class B) Oocytes ofD. Melanogasterto Low Doses of Ionizing Radiation: Effects in Repair-proficient (yw) and Repair-deficient Strains (Mei 41^D5and Mus 302^D1)

1991 • 44 citations

Adaptive Response in Embryogenesis: I. Dose and Timing of Radiation for Reduction of Prenatal Death and Congenital Malformation during the Late Period of Organogenesis

1998 • 43 citations

Genetic analysis of homologous DNA recombination in vertebrate somatic cells

2000 • 43 citations

Adaptive response in patients treated with 131I.

2000 • 42 citations

Identification and chromosomal assignment of two heterozygous mutations in the Trp53 gene in L5178Y\Tk ^+\−-3.7.2C mouse lymphoma cells

1998 • 41 citations

Cisplatin-modification of DNA repair and ionizing radiation lethality in yeast, Saccharomyces cerevisiae

1999 • 40 citations

Establishment and some mutational characteristics of 3T3‐like near‐diploid mouse cell line

1987 • 40 citations

Analysis of DNA damage recovery processes in the adaptive response to inonizing radiation in human lymphocytes

1996 • 40 citations

Absence of Adaptive Response to Low Doses of X-rays in Preimplantation Embryos and Spleen Lymphocytes of an Inbred Mouse Strain as Compared to Human Peripheral Lymphocytes: A Cytogenetic Study

1992 • 39 citations

Mutations of the ATM gene detected in Japanese ataxia-telangiectasia patients: possible preponderance of the two founder mutations 4612del165 and 7883del5

1998 • 39 citations

TheFANCA gene in Japanese Fanconi anemia: Reports of eight novel mutations and analysis of sequence variability

1999 • 37 citations

Ionizing radiation induced DNA lesions which lead to chromosomal aberrations

1993 • 37 citations

High Affinity Insertion/Deletion Lesion Binding by p53

1999 • 33 citations

Possible age-dependent adaptive response to a low dose of X-rays in human lymphocytes

1998 • 29 citations

Role of RAD9-dependent cell-cycle checkpoints in the adaptive response to ionizing radiation in yeast, Saccharomyces cerevisiae

2000 • 22 citations

Establishment of a Novel Immortalized Cell Line from Ataxia Telangiectasia Fibroblasts and Its Use for the Chromosomal Assignment of Radiosensitivity Gene

1990 • 21 citations

Increased sensitivity to chromatid aberration induction by bleomycin and neocarzinostatin results from alterations in a DNA damage response pathway

2000 • 21 citations

Mitogenic activity of 12-O-tetradecanoyl phorbol-13-acetate on peripheral blood lymphocytes from young and aged adults.

1982 • 20 citations

Adaptive Response in Mouse Embryos?

1992 • 17 citations

The adaptive response of peripheral blood lymphocytes to low doses of mutagenic agents in patients with ataxia telangiectasia

1995 • 17 citations

DNA-dependent protein kinase does not play a role in adaptive survival responses to ionizing radiation.

1998 • 16 citations

Age-Related Events in Human Active T Lymphocytes: Changes in the Phosphoinositidase C Activity

1993 • 16 citations

Dose rate effectiveness and potentially lethal damage repair in normal and double-strand break repair deficient murine cells by γ-rays and 5-fluorouracil

1998 • 14 citations

Cultured Cells from a Severe Combined Immunodeficient Mouse Have a Slower Than Normal Rate of Repair of Potentially Lethal Damage Sensitive to Hypertonic Treatment

1995 • 14 citations

The phytohemagglutinin response of human peripheral blood lymphocytes as a function of donor age: A re-examination using BrdU-Hoechst flow cytometry

1988 • 13 citations

Dissociation between radioresistant DNA replication and chromosomal radiosensitivity in ataxia telangiectasia cells

1994 • 10 citations

Tissue Misrepair Hypothesis for Radiation Carcinogenesis

1991 • 9 citations

Cell Cycle-Dependent Effects of Wortmannin on Radiation Survival and Mutation¹

2001 • 9 citations

Ligation mediated fluorescent labeling of DNA sequencing primers

1997 • 8 citations

Age-related events in active T subpopulations. Changes in polyphosphoinositide metabolism during mitogenic activation

1992 • 6 citations

Trans‐regulated Silencing and Reactivation of TP53 Tumor Suppressor Gene in Malignant Transformation and Its Reversion

2000 • 3 citations