Adaptive Response to DNA-Damaging Agents

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

The stress-activated protein kinase subfamily of c-Jun kinases

1994 • 2,616 citations

Cells in Stress: Transcriptional Activation of Heat Shock Genes

1993 • 1,429 citations

A Divergence in the MAP Kinase Regulatory Network Defined by MEK Kinase and Raf

1993 • 1,086 citations

Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun

1994 • 978 citations

Interaction of the p53-Regulated Protein Gadd45 with Proliferating Cell Nuclear Antigen

1994 • 941 citations

Tumor Necrosis Factor-α

1997 • 864 citations

Adaptive Response of Human Lymphocytes to Low Concentrations of Radioactive Thymidine

1984 • 817 citations

Differential induction of transcriptionally active p53 following UV or lonizing radiation: Defects in chromosome instability syndromes?

1993 • 799 citations

Induction of WAF1/CIP1 by a p53-independent pathway.

1994 • 773 citations

Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1

1994 • 706 citations

Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3.

1994 • 666 citations

Mitogen and stress response pathways: MAP kinase cascades and phosphatase regulation in mammals and yeast

1995 • 578 citations

scid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair.

1991 • 509 citations

The gadd and MyD genes define a novel set of mammalian genes encoding acidic proteins that synergistically suppress cell growth.

1994 • 484 citations

Transcription factors 1: bZIP proteins.

1995 • 385 citations

Cyclin-Binding Motifs Are Essential for the Function of p21^CIP1

1996 • 313 citations

Ionizing radiation regulates expression of the c-jun protooncogene.

1990 • 297 citations

Anisomycin-activated protein kinases p45 and p55 but not mitogen-activated protein kinases ERK-1 and -2 are implicated in the induction of c-fos and c-jun.

1994 • 296 citations

The molecular basis for cell cycle delays following ionizing radiation: a review

1994 • 293 citations

MAMMALIAN GENES INDUCED BY RADIATION; Activation of Genes Associated with Growth Control

1992 • 284 citations

Human Lymphocytes Exposed to Low Doses of Ionizing Radiations Become Refractory to High Doses of Radiation as Well as to Chemical Mutagens that Induce Double-strand Breaks in DNA

1988 • 283 citations

Protein kinase C mediates x-ray inducibility of nuclear signal transducers EGR1 and JUN.

1991 • 277 citations

Characterization of the Adaptive Response to Ionizing Radiation Induced by Low Doses of X Rays to Human Lymphocytes

1987 • 273 citations

Induction by ionizing radiation of the gadd45 gene in cultured human cells: lack of mediation by protein kinase C.

1991 • 268 citations

International Symposium on Pain

1974 • 243 citations

Evidence that the [³H]thymidine-induced adaptive response of human lymphocytes to subsequent doses of X-rays involves the induction of a chromosomal repair mechanism

1986 • 224 citations

Radioadaptive response: Efficient repair of radiation-induced DNA damage in adapted cells

1996 • 217 citations

Radiation-Induced Adaptive Response for Protection against Micronucleus Formation and Neoplastic Transformation in C3H 10T1/2 Mouse Embryo Cells

1994 • 216 citations

Increases in sequence specific DNA binding by p53 following treatment with chemotherapeutic and DNA damaging agents.

1993 • 201 citations

Effects of irradiation on the release of growth factors from cultured bovine, porcine, and human endothelial cells.

1989 • 197 citations

Tumor necrosis factor-mediated release of platelet-derived growth factor from cultured endothelial cells.

1987 • 188 citations

The C-terminal domain of p53 recognizes DNA damaged by ionizing radiation.

1995 • 188 citations

Induction of Cytogenetic Adaptive Response of Somatic and Germ Cellsin Vivoandin Vitroby Low-dose X-irradiation

1990 • 186 citations

Autocrine effects of fibroblast growth factor in repair of radiation damage in endothelial cells.

1991 • 186 citations

Aspects of the adaptive response to very low doses of radiation and other agents

1996 • 170 citations

Variability of the adaptive response to ionizing radiations in humans

1989 • 169 citations

Identification and characterization of X-ray-induced proteins in human cells.

1989 • 166 citations

UV-induced extracellular factor from human fibroblasts communicates the UV response to nonirradiated cells

1984 • 162 citations

Biological Consequences of Gene Regulation After Ionizing Radiation Exposure

1991 • 160 citations

Adaptive response of human lymphocytes to low-level radiation from radioisotopes or X-rays

1989 • 153 citations

Effects of ionizing radiation on cell cycle progression

1995 • 153 citations

Regulation of tumor necrosis factor gene expression by ionizing radiation in human myeloid leukemia cells and peripheral blood monocytes.

1991 • 148 citations

Isolation of x-ray-inducible transcripts from radioresistant human melanoma cells.

1993 • 136 citations

Regulation of protein kinase C by ionizing radiation.

1990 • 128 citations

Inhibition of the adaptive response of human lymphocytes to very low doses of ionizing radiation by the protein synthesis inhibitor cycloheximide

1989 • 124 citations

Tyrosine phosphorylation is a mandatory proximal step in radiation-induced activation of the protein kinase C signaling pathway in human B-lymphocyte precursors.

1993 • 123 citations

Basic Fribroblast Growth Factor Overexpression in Endothelial Cells: An Autocrine Mechanism for Angiogenesis and Angioproliferative Diseases

1998 • 109 citations

Human lymphocytes exposed to low doses of X-rays are less susceptible to radiation-induced mutagenesis

1991 • 107 citations

Radio-adaptive response: characterization of a cytogenetic repair induced by low-level ionizing radiation in cultured Chinese hamster cells

1989 • 104 citations

Cell cycle regulation in response to DNA damage in mammalian cells: A historical perspective

1995 • 104 citations

Adaptive response to chromosome damage in cultured human lymphocytes primed with low doses of X-rays

1991 • 96 citations

Mammalian 60-kDa Stress Protein (Chaperonin Homolog).

1995 • 89 citations

Occupational Exposure to Radiation Induces an Adaptive Response in Human Lymphocytes

1995 • 87 citations

Cytogenetic and survival adaptive responses in G1 phase human lymphocytes

1992 • 81 citations

Decreased Deletion Mutation in Radioadapted Human Lymphoblasts

1993 • 80 citations

Defective induction of stress-activated protein kinase activity in ataxia-telangiectasia cells exposed to ionizing radiation.

1995 • 75 citations

Altered G1 checkpoint control determines adaptive survival responses to ionizing radiation

1996 • 73 citations

Indications of an adaptive response in C57BL mice pre-exposed in vivo to low doses of ionizing radiation

1990 • 70 citations

A low, adaptive dose of gamma-rays reduced the number and altered the spectrum of S1− mutants in human-hamster hybrid AL cells

1996 • 69 citations

Mice Chronically Exposed to Low Dose Ionizing Radiation Possess Splenocytes with Elevated Levels of HSP70 mRNA, HSC70 and HSP72 and with an Increased Capacity to Proliferate

1993 • 67 citations

DNA-binding protein activated by gamma radiation in human cells.

1990 • 65 citations

Control of G1 arrest after DNA damage.

1993 • 64 citations

Induction of a cytogenetic adaptive response in germ cells of irradiated mice with very low-dose rate of chronic γ-irradiation and its biological influence on radiation-induced DNA or chromosomal damage and cell killing in their male offspring

1995 • 58 citations

Cytokine‐Regulated Expression of Platelet‐Derived Growth Factor Gene and Protein in Cultured Human Astrocytes

1996 • 57 citations

Role of radioadaptation on radiation-induced thymic lymphoma in mice

1996 • 56 citations

Alterations in Transcription Factor Binding in Radioresistant Human Melanoma Cells after Ionizing Radiation

1994 • 53 citations

Adaptive response to radiation damage in human lymphocytes conditioned with hydrogen peroxide as measured by the cytokinesis-block micronucleus technique

1993 • 49 citations

Low-dose radiation-induced adaptive response in bone marrow cells of mice

1993 • 49 citations

Induction of an adaptive response to dominant lethality and to chromosome damage of mouse germ cells by low dose radiation

1993 • 47 citations

Tumor necrosis factor α: Posttranscriptional stabilization of WAF1 mRNA in p53-deficient human leukemic cells

1996 • 47 citations

Adaptive response to 2 low doses of X-rays in human blood lymphocytes

1990 • 38 citations

The role of poly(ADP-ribosyl)ation in the adaptive response

1996 • 35 citations

Low Dose Radiation-Induced Adaptive Survival Response in Mouse Spleen T-lymphocytes in vivo.

1993 • 34 citations

Transcription factors

1995 • 33 citations

Cytogenetic adaptive response induced by pre-exposure in human lymphocytes and marrow cells of mice

1995 • 31 citations

Effect of low-dose radiation on repair of DNA and chromosome damage.

1990 • 30 citations

p53 accumulation in the organs of low-dose X-ray-irradiated mice

1996 • 30 citations

A BrdU pulse double-labelling method for studying adaptive response

1991 • 28 citations

Decreased sensitivity to the cytogenetic effects of bleomycin in individuals occupationally exposed to ionizing radiation

1996 • 28 citations

Sister-chromatid exchanges induced by mitomycin C after acute or chronic exposure of human lymphocytes to a low dose of X-rays

1989 • 27 citations

Adaptive response in human lymphocytes conditioned with hydrogen peroxide before irradiation with X-rays

1990 • 26 citations

Do human lymphocytes exposed to the fallout of the Chernobyl accident exhibit an adaptive response? III. Challenge with bleomycin in lymphocytes from children hit by the initial acute dose of ionizing radiation

1996 • 26 citations

Application of a multiple fixation regimen to study the adaptive response to ionizing radiation in lymphocytes of two human donors

1995 • 24 citations

Induction of cytogenetic adaptive response of mouse bone marrow cells to radiation by therapeutic doses of bleomycin sulfate and actinomycin D as assayed by the micronucleus test

1994 • 23 citations

Adaptive response to mutagenesis and its molecular basis in a human T-cell leukemia line primed with a low dose of?-rays

1994 • 23 citations

Adaptive Response to Low Doses of .GAMMA.-Ray in Chinese Hamster Cells: Determined by Cell Survival and DNA Synthesis.

1994 • 22 citations

Ionizing Radiation Damage to DNA

1999 • 22 citations

Induction of the 72-kD Heat Shock Protein in Xeroderma Pigmentosum Complementation Group A Fibroblasts

1992 • 22 citations

Purification and characterization of a DNA-binding protein activated by ionizing radiation.

1992 • 20 citations

On the Genetic Background of the Adaptive Response to X-rays inDrosophila Melanogaster

1994 • 19 citations

Cell cycle checkpoints and repair of ionizing radiation damage.

1995 • 18 citations

The adaptive response of peripheral blood lymphocytes to low doses of mutagenic agents in patients with ataxia telangiectasia

1995 • 17 citations

Study on the mechanism of cytogenetic adaptive response induced by low dose radiation.

1992 • 16 citations

Chromosomal analysis of Chinese hamster V79 cells exposed to multiple γ-ray fractions: induction of adaptive response to mitomycin C

1992 • 14 citations

Indications of repair of radon-induced chromosome damage in human lymphocytes: an adaptive response induced by low doses of X-rays.

1993 • 13 citations

Adaptive response to ionizing radiation induced by low dose of gamma ray in human hepatoma cell lines

1994 • 12 citations

Accumulative effect of two low doses of irradiation in inducing an adaptive response in human lymphocytes

1993 • 11 citations

Transcription factor encoding oncogenes

1992 • 9 citations

Studies on the induction of cross-resistance by low dose radiation or by low concentrations of chemicals.

1994 • 6 citations

Le phénomène de résistance multiple aux anticancéreux : les gènes MDR et la P-gp

1990 • 5 citations

Radio-adaptive response

1991 • 4 citations

Studies of the 'Adaptive' Repair Response in Human Lymphocytes and V79 Cells after Treatment with MNNG and MNU

1988 • 4 citations