The p38MAPK Inhibitor SB203580 Alleviates Ultraviolet-Induced Phosphorylation at Serine 389 but Not Serine 15 and Activation of p53

p53, the Cellular Gatekeeper for Growth and Division

1997 • 7,621 citations

Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

1995 • 5,334 citations

Mdm2 promotes the rapid degradation of p53

1997 • 4,336 citations

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

1994 • 3,285 citations

Regulation of p53 stability by Mdm2

1997 • 3,238 citations

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1992 • 3,110 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

Crystal Structure of a p53 Tumor Suppressor-DNA Complex: Understanding Tumorigenic Mutations

1994 • 2,460 citations

p53: puzzle and paradigm.

1996 • 2,363 citations

Pro-inflammatory Cytokines and Environmental Stress Cause p38 Mitogen-activated Protein Kinase Activation by Dual Phosphorylation on Tyrosine and Threonine

1995 • 2,238 citations

DNA Damage-Induced Phosphorylation of p53 Alleviates Inhibition by MDM2

1997 • 2,089 citations

SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin‐1

1995 • 2,080 citations

Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53

1998 • 2,034 citations

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

1997 • 1,906 citations

The p53-mdm-2 autoregulatory feedback loop.

1993 • 1,795 citations

Enhanced Phosphorylation of p53 by ATM in Response to DNA Damage

1998 • 1,734 citations

Independent Human MAP-Kinase Signal Transduction Pathways Defined by MEK and MKK Isoforms

1995 • 1,562 citations

The complexity of p53 modulation: emerging patterns from divergent signals

1998 • 1,319 citations

Cyclin D1 Expression Is Regulated Positively by the p42/p44 and Negatively by the p38/HOG Pathway

1996 • 1,203 citations

Monoclonal antibodies specific for simian virus 40 tumor antigens

1981 • 1,110 citations

A role for ATR in the DNA damage-induced phosphorylation of p53

1999 • 1,043 citations

Stress-Induced Phosphorylation and Activation of the Transcription Factor CHOP (GADD153) by p38 MAP Kinase

1996 • 893 citations

DNA damage induces phosphorylation of the amino terminus of p53

1997 • 829 citations

Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation

1997 • 770 citations

Mapping of the p53 and mdm-2 interaction domains.

1993 • 658 citations

FGF and stress regulate CREB and ATF-1 via a pathway involving p38 MAP kinase and MAPKAP kinase-2.

1996 • 633 citations

Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein

1998 • 610 citations

MEKK1/JNK signaling stabilizes and activates p53

1998 • 521 citations

ATM associates with and phosphorylates p53: mapping the region of interaction

1998 • 494 citations

p53 in growth control and neoplasia

1996 • 488 citations

ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins

1998 • 471 citations

p38 Mitogen-activated Protein Kinase Phosphorylates Cytosolic Phospholipase A2 (cPLA2) in Thrombin-stimulated Platelets

1996 • 466 citations

Ribotoxic Stress Response: Activation of the Stress-Activated Protein Kinase JNK1 by Inhibitors of the Peptidyl Transferase Reaction and by Sequence-Specific RNA Damage to the α-Sarcin/Ricin Loop in the 28S rRNA

1997 • 463 citations

Regulation of p53 Function and Stability by Phosphorylation

1999 • 443 citations

Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases

1997 • 424 citations

JNK targets p53 ubiquitination and degradation in nonstressed cells

1998 • 339 citations

MDM2 Suppresses p73 Function without Promoting p73 Degradation

1999 • 329 citations

Signaling by dual specificity kinases

1998 • 291 citations

p53 Is Phosphorylated in Vitro and in Vivo by an Ultraviolet Radiation-induced Protein Kinase Characteristic of the c-Jun Kinase, JNK1

1995 • 256 citations

The Activation of the c-Jun N-terminal Kinase and p38 Mitogen-activated Protein Kinase Signaling Pathways Protects HeLa Cells from Apoptosis Following Photodynamic Therapy with Hypericin

1999 • 217 citations

Functional activation of p53 via phosphorylation following DNA damage by UV but not γ radiation

1998 • 210 citations

A functionally inactive p53 protein interatocarcinoma cells is activated by either DNA damage or cellular differentiation

1996 • 209 citations

Regulation of Mdm2-Directed Degradation by the C Terminus of p53

1998 • 194 citations

Ultraviolet Radiation Triggers the Ribotoxic Stress Response in Mammalian Cells

1998 • 181 citations

Ultraviolet radiation, but not γ radiation or etoposide-induced DNA damage, results in the phosphorylation of the murine p53 protein at serine-389

1998 • 161 citations

DNA damage induced p53 stabilization: no indication for an involvement of p53 phosphorylation

1999 • 152 citations

The CDK₇-cycH-p36 Complex of Transcription Factor IIH Phosphorylates p53, Enhancing Its Sequence-Specific DNA Binding Activity In Vitro

1997 • 152 citations

Two Distinct Signaling Pathways Activate the Latent DNA Binding Function of p53 in a Casein Kinase II-independent Manner

1995 • 109 citations

Mutation of Phosphoserine 389 Affects p53 Function in Vivo

1996 • 103 citations

The carboxyl-terminal domain of the p53 protein regulates sequence-specific DNA binding through its nonspecific nucleic acid-binding activity.

1995 • 101 citations

Alternatively spliced p53 RNA in transformed and normal cells of different tissue types

1992 • 58 citations

Measuring magnets on a micron scale

1994 • 5 citations