p53 directly enhances rejoining of DNA double-strand breaks with cohesive ends in gamma-irradiated mouse fibroblasts.

p53, the Cellular Gatekeeper for Growth and Division

1997 • 7,621 citations

Cancer Cell Cycles

1996 • 5,379 citations

p53: puzzle and paradigm.

1996 • 2,363 citations

Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells

1998 • 1,202 citations

Involvement of the p53 tumor suppressor in repair of u.v.-type DNA damage.

1995 • 365 citations

p53 is linked directly to homologous recombination processes via RAD51/RecA protein interaction.

1996 • 346 citations

The BRCA 2 gene product functionally interacts with p53 and RAD51

1998 • 263 citations

p53 Protein Exhibits 3′-to-5′ Exonuclease Activity

1996 • 248 citations

Inactivation of p53 results in high rates of homologous recombination

1997 • 225 citations

The p53 gene as a modifier of intrinsic radiosensitivity: implications for radiotherapy

1996 • 195 citations

p53 involvement in control of G2 exit of the cell cycle: role in DNA damage-induced apoptosis.

1995 • 147 citations

Human fibroblasts expressing the human papillomavirus E6 gene are deficient in global genomic nucleotide excision repair and sensitive to ultraviolet irradiation.

1998 • 120 citations

Nijmegen Breakage Syndrome Cells Fail To Induce the p53-Mediated DNA Damage Response following Exposure to Ionizing Radiation

1997 • 119 citations

The carboxyl-terminal domain of the p53 protein regulates sequence-specific DNA binding through its nonspecific nucleic acid-binding activity.

1995 • 101 citations

p53 deficiency does not affect the accumulation of point mutations in a transgene target.

1995 • 83 citations

The Ability of p53 to Activate Downstream Genes p21 and MDM2, and Cell Cycle Arrest following DNA Damage Is Delayed and Attenuated in scid Cells Deficient in the DNA-dependent Protein Kinase

1999 • 56 citations

A role for p53 in DNA end rejoining by human cell extracts

1997 • 47 citations

Radioresistant MTp53-expressing rat embryo cell transformants exhibit increased DNA-dsb rejoining during exposure to ionizing radiation

1998 • 45 citations

p53-null cells are more sensitive to ultraviolet light only in the presence of caffeine.

1996 • 42 citations

Double-Strand Break and Recombinational Repair in Saccharomyces cerevisiae

2003 • 31 citations

Evidence of the involvement of p53 in gamma -radiation-induced DNA repair in human lymphoblasts

1998 • 19 citations

p53-mediated transcription induces resistance of DNA to UV inactivation

1998 • 17 citations