DNA end-joining: from yeast to man

The hMre11/hRad50 Protein Complex and Nijmegen Breakage Syndrome: Linkage of Double-Strand Break Repair to the Cellular DNA Damage Response

1998 • 1,220 citations

The DNA-dependent protein kinase: Requirement for DNA ends and association with Ku antigen

1993 • 1,219 citations

Nibrin, a Novel DNA Double-Strand Break Repair Protein, Is Mutated in Nijmegen Breakage Syndrome

1998 • 1,071 citations

The 3′ to 5′ Exonuclease Activity of Mre11 Facilitates Repair of DNA Double-Strand Breaks

1998 • 887 citations

Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells

1997 • 667 citations

Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing

1998 • 636 citations

The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability.

1995 • 601 citations

Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints

1998 • 533 citations

A Protein-Counting Mechanism for Telomere Length Regulation in Yeast

1997 • 514 citations

Saccharomyces cerevisiae Ku70 potentiates illegitimate DNA double-strand break repair and serves as a barrier to error-prone DNA repair pathways.

1996 • 492 citations

Identification of a Saccharomyces cerevisiae Ku80 homologue: roles in DNA double strand break rejoining and in telomeric maintenance

1996 • 478 citations

Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV

1997 • 461 citations

The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination

1995 • 449 citations

Yeast DNA ligase IV mediates non-homologous DNA end joining

1997 • 412 citations

Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination

1997 • 396 citations

Telomere maintenance is dependent on activities required for end repair of double-strand breaks

1998 • 369 citations

Mutation of yeast Ku genes disrupts the subnuclear organization of telomeres

1998 • 345 citations

DNA double-strand break repair and V(D)J recombination: involvement of DNA-PK

1995 • 344 citations

Positional cloning of the gene for Nijmegen breakage syndrome

1998 • 336 citations

Silencing factors participate in DNA repair and recombination in Saccharomyces cerevisiae

1997 • 330 citations

Interaction of DNA-dependent protein kinase with DNA and with Ku: biochemical and atomic-force microscopy studies

1997 • 315 citations

Ku protein stimulates DNA end joining by mammalian DNA ligases: a direct role for Ku in repair of DNA double-strand breaks

1998 • 292 citations

Mutations in Two Ku Homologs Define a DNA End-Joining Repair Pathway in Saccharomyces cerevisiae

1996 • 275 citations

Identification of Saccharomyces cerevisiae DNA ligase IV: involvement in DNA double-strand break repair

1997 • 257 citations

DNA looping by Ku and the DNA-dependent protein kinase

1997 • 249 citations

The DNA-binding Protein Hdf1p (a Putative Ku Homologue) Is Required for Maintaining Normal Telomere Length in Saccharomyces Cerevisiae

1996 • 246 citations

DNA-dependent protein kinase: DNA binding and activation in the absence of Ku

1998 • 238 citations

Homologous recombination and the roles of double-strand breaks

1995 • 234 citations

Human Rad50 Is Physically Associated with Human Mre11: Identification of a Conserved Multiprotein Complex Implicated in Recombinational DNA Repair

1996 • 219 citations

Molecular model for telomeric heterochromatin in yeast

1997 • 215 citations

A newly identified DNA ligase of Saccharomyces cerevisiaeinvolved in RAD52-independent repair of DNA double-strand breaks

1997 • 189 citations

The Saccharomyces cerevisiae Ku Autoantigen Homologue Affects Radiosensitivity Only in the Absence of Homologous Recombination

1996 • 189 citations

The XRCC4 Gene Product Is a Target for and Interacts with the DNA-dependent Protein Kinase

1998 • 188 citations

Purification and characterization of a template-associated protein kinase that phosphorylates RNA polymerase II

1993 • 184 citations

Ku80-deficient Cells Exhibit Excess Degradation of Extrachromosomal DNA

1996 • 175 citations

Saccharomyces cerevisiae LIF1: a function involved in DNA double-strand break repair related to mammalian XRCC4

1998 • 167 citations

Cell-free V(D)J recombination

1997 • 143 citations

The sbcC and sbcD genes of Escherichia coli encode a nuclease involved in palindrome inviability and genetic recombination

1996 • 141 citations

Alteration of telomeric sequences and senescence caused by mutations in RAD50 of Saccharomyces cerevisiae

1997 • 135 citations

Isolation and Characterization of the Human MRE11 Homologue

1995 • 127 citations

DNA-dependent protein kinase: a potent inhibitor of transcription by RNA polymerase I.

1995 • 121 citations

Mammalian DNA ligases

1997 • 119 citations

HDF2, the Second Subunit of the Ku Homologue from Saccharomyces cerevisiae

1996 • 85 citations

Involvement of the Saccharomyces cerevisiae HDF1 Gene in DNA Double-strand Break Repair and Recombination

1996 • 65 citations

DNA-dependent protein kinase specifically represses promoter-directed transcription initiation by RNA polymerase I.

1995 • 63 citations

Ku86 Is Not Required for Protection of Signal Ends or for Formation of Nonstandard V(D)J Recombination Products

1997 • 61 citations

DNA damage detection by DNA dependent protein kinase and related enzymes.

1996 • 53 citations

Specificity in V(D)J recombination: new lessons from biochemistry and genetics

1997 • 40 citations