Genetic analysis of homologous DNA recombination in vertebrate somatic cells

Instability and decay of the primary structure of DNA

1993 • 5,370 citations

DNA Repair and Mutagenesis

2006 • 4,725 citations

The double-strand-break repair model for recombination

1983 • 2,468 citations

DNA repair and mutagenesis

1996 • 2,289 citations

Association of BRCA1 with Rad51 in Mitotic and Meiotic Cells

1997 • 1,466 citations

XRCC3 promotes homology-directed repair of DNA damage in mammalian cells

1999 • 1,322 citations

Rad51 protein involved in repair and recombination in S. cerevisiae is a RecA-like protein

1992 • 1,231 citations

The hMre11/hRad50 Protein Complex and Nijmegen Breakage Syndrome: Linkage of Double-Strand Break Repair to the Cellular DNA Damage Response

1998 • 1,220 citations

Brca1 Controls Homology-Directed DNA Repair

1999 • 1,205 citations

Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells

1998 • 1,202 citations

The Genetic Basis of Human Cancer

1997 • 1,113 citations

Nibrin, a Novel DNA Double-Strand Break Repair Protein, Is Mutated in Nijmegen Breakage Syndrome

1998 • 1,071 citations

Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

1997 • 1,055 citations

The DNA Double-Strand Break Repair Gene hMRE11 Is Mutated in Individuals with an Ataxia-Telangiectasia-like Disorder

1999 • 1,052 citations

Requirement of ATM-Dependent Phosphorylation of Brca1 in the DNA Damage Response to Double-Strand Breaks

1999 • 1,005 citations

Dynamic Changes of BRCA1 Subnuclear Location and Phosphorylation State Are Initiated by DNA Damage

1997 • 910 citations

The 3′ to 5′ Exonuclease Activity of Mre11 Facilitates Repair of DNA Double-Strand Breaks

1998 • 887 citations

Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation

1995 • 862 citations

Catalysis of ATP-Dependent Homologous DNA Pairing and Strand Exchange by Yeast RAD51 Protein

1994 • 843 citations

The Genetic Basis of Human Cancer

1999 • 827 citations

Centrosome Amplification and a Defective G2–M Cell Cycle Checkpoint Induce Genetic Instability in BRCA1 Exon 11 Isoform–Deficient Cells

1999 • 814 citations

Rad51-deficient vertebrate cells accumulate chromosomal breaks prior to cell death

1998 • 793 citations

Targeted disruption of the Rad51 gene leads to lethality in embryonic mice.

1996 • 789 citations

Introduction of double-strand breaks into the genome of mouse cells by expression of a rare-cutting endonuclease.

1994 • 734 citations

Human Rad51 Protein Promotes ATP-Dependent Homologous Pairing and Strand Transfer Reactions In Vitro

1996 • 670 citations

Similarity of the Yeast RAD51 Filament to the Bacterial RecA Filament

1993 • 654 citations

Homology-directed repair is a major double-strand break repair pathway in mammalian cells

1998 • 628 citations

Stable Interaction between the Products of the BRCA1 and BRCA2 Tumor Suppressor Genes in Mitotic and Meiotic Cells

1998 • 625 citations

Involvement of Brca2 in DNA Repair

1998 • 624 citations

Association of BRCA1 with the hRad50-hMre11-p95 Complex and the DNA Damage Response

1999 • 621 citations

Post-translational modification of poly(ADP-ribose) polymerase induced by DNA strand breaks

1995 • 600 citations

Rad52 protein stimulates DNA strand exchange by Rad51 and replication protein A

1998 • 576 citations

Nuclear foci of mammalian Rad51 recombination protein in somatic cells after DNA damage and its localization in synaptonemal complexes.

1995 • 556 citations

PARP is important for genomic stability but dispensable in apoptosis

1997 • 556 citations

Function of Yeast Rad52 Protein as a Mediator between Replication Protein A and the Rad51 Recombinase

1997 • 551 citations

Role of the human RAD51 protein in homologous recombination and double-stranded-break repair

1998 • 550 citations

Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos.

1997 • 537 citations

Increased ratio of targeted to random integration after transfection of chicken B cell lines

1991 • 534 citations

Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex

1999 • 533 citations

XRCC2 and XRCC3, New Human Rad51-Family Members, Promote Chromosome Stability and Protect against DNA Cross-Links and Other Damages

1998 • 530 citations

Molecular mechanisms of DNA double-strand break repair

1998 • 515 citations

hMre11 and hRad50 Nuclear Foci Are Induced During the Normal Cellular Response to DNA Double-Strand Breaks †

1997 • 504 citations

In Situ Visualization of DNA Double-Strand Break Repair in Human Fibroblasts

1998 • 503 citations

BRCA1 Required for Transcription-Coupled Repair of Oxidative DNA Damage

1998 • 502 citations

ATAXIA-TELANGIECTASIA AND THE NIJMEGEN BREAKAGE SYNDROME: Related Disorders But Genes Apart

1997 • 489 citations

Cloning of human, mouse and fission yeast recombination genes homologous to RAD51 and recA

1993 • 486 citations

A genetic study of X-ray sensitive mutants in yeast

1974 • 478 citations

Stimulation by Rad52 of yeast Rad51- mediated recombination

1998 • 459 citations

Highly efficient gene targeting in embryonic stem cells through homologous recombination with isogenic DNA constructs.

1992 • 450 citations

Disruption of Mouse RAD54 Reduces Ionizing Radiation Resistance and Homologous Recombination

1997 • 438 citations

Double-strand break repair by interchromosomal recombination: suppression of chromosomal translocations

1998 • 435 citations

Sister Chromatid Exchanges Are Mediated by Homologous Recombination in Vertebrate Cells

1999 • 427 citations

Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation

1997 • 426 citations

Catalysis of homologous DNA pairing by yeast Rad51 and Rad54 proteins

1998 • 426 citations

DNA recombination: the replication connection

1999 • 411 citations

Nuclease Activities in a Complex of Human Recombination and DNA Repair Factors Rad50, Mre11, and p95

1998 • 410 citations

BRCA2 is required for ionizing radiation-induced assembly of Rad51 complex in vivo.

1999 • 406 citations

Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation

1999 • 402 citations

The Many Interfaces of Mre11

1998 • 401 citations

The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment

1998 • 389 citations

Synergistic actions of Rad51 and Rad52 in recombination and DNA repair

1998 • 367 citations

Nuclear foci of mammalian recombination proteins are located at single-stranded DNA regions formed after DNA damage

1999 • 348 citations

p53 is linked directly to homologous recombination processes via RAD51/RecA protein interaction.

1996 • 346 citations

Reexamination of Gene Targeting Frequency as a Function of the Extent of Homology between the Targeting Vector and the Target Locus

1992 • 330 citations

Mammalian XRCC2 promotes the repair of DNA double-strand breaks by homologous recombination

1999 • 327 citations

A targeted disruption of the murine Brca1 gene causes γ-irradiation hypersensitivity and genetic instability

1998 • 325 citations

HOMOLOGOUS PAIRING AND DNA STRAND-EXCHANGE PROTEINS

1994 • 324 citations

Targeted Inactivation of Mouse RAD52Reduces Homologous Recombination but Not Resistance to Ionizing Radiation

1998 • 317 citations

Absence of Brca2 causes genome instability by chromosome breakage and loss associated with centrosome amplification

1999 • 315 citations

Overexpression of Rad51 protein stimulates homologous recombination and increases resistance of mammalian cells to ionizing radiation

1998 • 314 citations

Binding of double-strand breaks in DNA by human Rad52 protein

1999 • 314 citations

Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells

1997 • 309 citations

The controlling role of ATM in homologous recombinational repair of DNA damage

2000 • 308 citations

Mre11 is essential for the maintenance of chromosomal DNA in vertebrate cells

1999 • 286 citations

Rad52 forms ring structures and co‐operates with RPA in single‐strand DNA annealing

1998 • 284 citations

Reduced X-Ray Resistance and Homologous Recombination Frequencies in a RAD54 Mutant of the Chicken DT40 Cell Line

1997 • 277 citations

The Rad51 Paralog Rad51B Promotes Homologous Recombinational Repair

2000 • 263 citations

Xrcc3 Is Required for Assembly of Rad51 Complexes in Vivo

1998 • 251 citations

Homologous and non-homologous recombination differentially affect DNA damage repair in mice

2000 • 245 citations

Mre11 and Ku70 interact in somatic cells, but are differentially expressed in early meiosis

1999 • 234 citations

Homologous recombination and the roles of double-strand breaks

1995 • 234 citations

Ku70

1998 • 231 citations

Reexamination of gene targeting frequency as a function of the extent of homology between the targeting vector and the target locus.

1992 • 230 citations

Dominant negative alleles of RAD52 reveal a DNA repair/recombination complex including Rad51 and Rad52.

1993 • 228 citations

Homologous Recombination, but Not DNA Repair, Is Reduced in Vertebrate Cells Deficient in RAD52

1998 • 226 citations

Human Rad50 Is Physically Associated with Human Mre11: Identification of a Conserved Multiprotein Complex Implicated in Recombinational DNA Repair

1996 • 219 citations

Mouse Rad54 affects DNA conformation and DNA-damage-induced Rad51 foci formation

1999 • 213 citations

Yeast Rad54 Promotes Rad51-dependent Homologous DNA Pairing via ATP Hydrolysis-driven Change in DNA Double Helix Conformation

1999 • 209 citations

Evidence for Simultaneous Protein Interactions between Human Rad51 Paralogs

2000 • 195 citations

Isolation and characterization of RAD51C, a new human member of the RAD51 family of related genes

1998 • 177 citations

Disruption of muREC2/RAD51L1 in Mice Results in Early Embryonic Lethality Which Can Be Partially Rescued in a p53^−/− Background

1999 • 166 citations

S phase specific formation of the human Rad51 protein nuclear foci in lymphocytes.

1996 • 163 citations

Therapeutic gene targeting

1998 • 162 citations

A surfeit of RAD51-like genes?

1999 • 157 citations

Midgestation lethality in mice deficient for the RecA-related gene,Rad51d/Rad51l3

2000 • 154 citations

Human and mouse homologs of the Saccharomyces cerevisiaeRAD54 DNA repair gene: evidence for functional conservation

1996 • 152 citations

The XRCC2 DNA repair gene from human and mouse encodes a novel member of the recA/RAD51 family

1998 • 149 citations

The Human Rad54 Recombinational DNA Repair Protein Is a Double-stranded DNA-dependent ATPase

1998 • 148 citations

Evolutionary Comparisons of RecA-Like Proteins Across All Major Kingdoms of Living Organisms

1997 • 138 citations

Mutations of a novel human RAD54 homologue, RAD54B, in primary cancer

1999 • 135 citations

Gene targeting and somatic cell genetics: a rebirth or a coming of age?

1999 • 112 citations

Visualisation of human rad52 protein and its complexes with hrad51 and DNA

1998 • 109 citations

Expression of Human RAD52 Confers Resistance to Ionizing Radiation in Mammalian Cells

1995 • 102 citations

Gene targeting is enhanced in human cells overexpressing hRAD51

1999 • 97 citations

Localization and dynamic relocalization of mammalian Rad52 during the cell cycle and in response to DNA damage

1999 • 71 citations

Identification of a chicken RAD52 homologue suggests conservation of the RAD52 recombination pathway throughout the evolution of higher eukaryotes

1993 • 64 citations

Deleted Work

1955 • 0 citations