Class II transactivator and class II MHC gene expression in microglia: modulation by the cytokines TGF-β, IL-4, IL-13 and IL-10

STATs and Gene Regulation

1997 • 3,927 citations

Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression.

1991 • 1,950 citations

Microglia: Intrinsic immuneffector cell of the brain

1995 • 1,099 citations

Cytotoxicity of microglia

1993 • 1,042 citations

Regulation of MHC Class II Expression by Interferon-γ Mediated by the Transactivator Gene CIITA

1994 • 854 citations

Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer's disease

1993 • 832 citations

Effects of IL-13 on phenotype, cytokine production, and cytotoxic function of human monocytes. Comparison with IL-4 and modulation by IFN-gamma or IL-10.

1993 • 657 citations

Antigen presentation and tumor cytotoxicity by interferon‐γ‐treated microglial cells

1987 • 648 citations

Microglia in degenerative neurological disease

1993 • 594 citations

Role of macrophages/microglia in multiple sclerosis and experimental allergic encephalomyelitis

1997 • 534 citations

Expression of MHC class II molecules in different cellular and functional compartments is controlled by differential usage of multiple promoters of the transactivator CIITA

1997 • 510 citations

Activation of the MHC Class II Transactivator CIITA by Interferon-γ Requires Cooperative Interaction between Stat1 and USF-1

1998 • 358 citations

Mice Lacking the MHC Class II Transactivator (CIITA) Show Tissue-Specific Impairment of MHC Class II Expression

1996 • 356 citations

MHC antigen expression on bulk isolated macrophage-microglia from newborn mouse brain: induction of Ia antigen expression by γ-interferon

1987 • 346 citations

Transforming growth factor-beta suppresses activation and proliferation of microglia in vitro.

1993 • 303 citations

Interleukin-10 Down-Regulates MHC Class II αβ Peptide Complexes at the Plasma Membrane of Monocytes by Affecting Arrival and Recycling

1997 • 302 citations

Neurotrophins inhibit major histocompatibility class II inducibility of microglia: Involvement of the p75 neurotrophin receptor

1998 • 283 citations

Microglia Are More Efficient Than Astrocytes in Antigen Processing and in Th1 But Not Th2 Cell Activation

1998 • 275 citations

IL-4-induced immune deviation as antigen-specific therapy for inflammatory autoimmune disease

1996 • 270 citations

Modulation of murine macrophage function by IL-13.

1993 • 251 citations

Impaired IL-13-mediated functions of macrophages in STAT6-deficient mice.

1996 • 243 citations

The central nervous system as an immunocompetent organ: role of glial cells in antigen presentation.

1996 • 230 citations

IL-4 and IL-13 receptors: are they one and the same?

1996 • 188 citations

TGF-beta suppresses IFN-gamma induction of class II MHC gene expression by inhibiting class II transactivator messenger RNA expression.

1997 • 177 citations

Antigen presentation in the central nervous system. The inhibitory effect of IL-10 on MHC class II expression and production of cytokines depends on the inducing signals and the type of cell analyzed.

1994 • 168 citations

B7/BB‐1 antigen expression on adult human microglia studied in vitro and in situ

1994 • 167 citations

Immune regulation by brain cells in the central nervous system: microglia but not astrocytes present myelin basic protein to encephalitogenic T cells under in vivo-mimicking conditions.

1992 • 160 citations

Macrophage colony-stimulating factor in human fetal astrocytes and microglia. Differential regulation by cytokines and lipopolysaccharide, and modulation of class II MHC on microglia.

1993 • 151 citations

Molecular analysis of G1B and G3A IFNγ mutants reveals that defects in CIITA or RFX result in defective class II MHC and li gene induction

1994 • 145 citations

Cytokines: Influence on Glial Cell Gene Expression and Function

1997 • 145 citations

Stat1 alpha expression is involved in IFN-gamma induction of the class II transactivator and class II MHC genes.

1996 • 125 citations

Quantitative control of MHC class II expression by the transactivator CIITA

1998 • 117 citations

Class II MHC gene expression in microglia. Regulation by the cytokines IFN-gamma, TNF-alpha, and TGF-beta.

1995 • 111 citations

Modulation of interferon-gamma-induced major histocompatibility complex class II and Fc receptor expression on isolated microglia by transforming growth factor-beta 1, interleukin-4, noradrenaline and glucocorticoids.

1993 • 95 citations

Post-transcriptional inhibition of CD40 gene expression in microglia by transforming growth factor-β

1998 • 94 citations

Interleukin-4 induces proliferation and activation of microglia but suppresses their induction of class II major histocompatibility complex antigen expression

1994 • 93 citations

Mouse microglial cell lines differing in constitutive and interferon-γ-inducible antigen-presenting activities for naive and memory CD4+ and CD8+ T cells

1995 • 92 citations

Induction and regulation of class II major histocompatibility complex mRNA expression in astrocytes by interferon-γ and tumor necrosis factor-α

1990 • 91 citations

IL-4 abrogates the inhibitory effect of IL-10 on the development of experimental allergic encephalomyelitis in SJL mice [published erratum appears in Int Immunol 1997 Nov;9(11):1773]

1997 • 76 citations

Microglial cells qualify as the stimulators of unprimed CD4+ and CD8+ T lymphocytes in the central nervous system

1994 • 74 citations

Regulation of the expression of multiple class II genes in murine B cells by B cell stimulatory factor-1 (BSF-1).

1986 • 70 citations

Role of protein kinase C and tyrosine kinase activity in IFN-gamma-induced expression of the class II MHC gene

1995 • 69 citations

Inhibition of interferon-gamma-induced major histocompatibility complex class II gene transcription by interferon-beta and type beta 1 transforming growth factor in human astrocytoma cells. Definition of cis-element.

1993 • 64 citations

Regulation of Class II MHC Expression

1996 • 63 citations

Interferon-gamma-induced astrocyte class II major histocompatibility complex gene expression is associated with both protein kinase C activation and Na+ entry.

1991 • 61 citations

TGF-beta suppression of IFN-gamma-induced class II MHC gene expression does not involve inhibition of phosphorylation of JAK1, JAK2, or signal transducers and activators of transcription, or modification of IFN-gamma enhanced factor X expression.

1995 • 55 citations

IL-1 beta inhibits IFN-gamma-induced class II MHC expression by suppressing transcription of the class II transactivator gene.

1999 • 38 citations

IL-1β Inhibits IFN-γ-Induced Class II MHC Expression by Suppressing Transcription of the Class II Transactivator Gene

1999 • 33 citations

Human microglia activate lymphoproliferative responses to recall viral antigens

1996 • 31 citations

Gene therapy in the treatment of autoimmune disease

1998 • 29 citations

Granulocyte-macrophage colony stimulating factor inhibits class II major histocompatibility complex expression and antigen presentation by microglia

1993 • 26 citations

Interferon γ (IFNγ) gene transfer of an EMT6 tumor that is poorly responsive to IFNγ stimulation: increase in tumor immunogenicity is accompanied by induction of a mouse class II transactivator and class II MHC

1996 • 23 citations

Gene therapy in the treatment of autoimmune disease

1998 • 16 citations

Interleukin-4 down-regulates MHC class II antigens on cultured rat astrocytes

1996 • 14 citations

Granulocyte-macrophage colony stimulating factor inhibits class II major histocompatibility complex expression and antigen presentation by microglia

1995 • 4 citations

Deleted Work

1955 • 0 citations