Gene therapy in the treatment of autoimmune disease

Transcriptional Activation by Tetracyclines in Mammalian Cells

1995 • 2,458 citations

B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy

1995 • 1,695 citations

Multiple sclerosis: Remyelination of nascent lesions: Remyelination of nascent lesions

1993 • 556 citations

Pancreatic expression of interleukin-4 abrogates insulitis and autoimmune diabetes in nonobese diabetic (NOD) mice.

1996 • 311 citations

Production of interleukin 10 by islet cells accelerates immune-mediated destruction of beta cells in nonobese diabetic mice.

1994 • 300 citations

Local Delivery of Interleukin 4 by Retrovirus-Transduced T Lymphocytes Ameliorates Experimental Autoimmune Encephalomyelitis

1997 • 264 citations

Multiple sclerosis

1993 • 229 citations

Adenoviral-mediated gene transfer to rabbit synovium in vivo.

1993 • 186 citations

Leukocyte extravasation into the pancreatic tissue in transgenic mice expressing interleukin 10 in the islets of Langerhans.

1993 • 183 citations

Treatment of Experimental Autoimmune Encephalomyelitis with Genetically Modified Memory T Cells

1997 • 180 citations

Regulation of Oligodendrocyte Development and CNS Myelination by Growth Factors: Prospects for Therapy of Demyelinating Disease

1996 • 176 citations

Long-term control of erythropoietin secretion by doxycycline in mice transplanted with engineered primary myoblasts

1997 • 173 citations

Constitutive Expression of Interleukin (IL)-4 In Vivo Causes Autoimmune-type Disorders in Mice

1997 • 151 citations

Chronic Relapsing Experimental Allergic Encephalomyelitis

1979 • 147 citations

Prevention of adoptively transferred diabetes in nonobese diabetic mice with IL-10-transduced islet-specific Th1 lymphocytes. A gene therapy model for autoimmune diabetes.

1996 • 128 citations

A myelin proteolipid protein-LacZ fusion protein is developmentally regulated and targeted to the myelin membrane in transgenic mice.

1993 • 123 citations

Glial-cell transplantation and plasticity in the O-2A lineage — implications for CNS repair

1995 • 112 citations

The potential of extrachromosomal replicating vectors for gene therapy

1996 • 91 citations

Anti-T Cell Receptor Monoclonal Antibody Prolongs Transgene Expression Following Adenovirus-MediatedIn VivoGene Transfer to Mouse Synovium

1996 • 84 citations

Gene transfer through the blood–nerve barrier: NGF-engineered neuritogenic T lymphocytes attenuate experimental autoimmune neuritis

1995 • 78 citations

Gene Transfer to Synovial Cells by Intra-Articular Administration of Plasmid DNA

1995 • 68 citations

Cytokines and gene therapy

1995 • 60 citations

Regulation of autoimmune response

1994 • 38 citations

Regeneration of oligodendrocytes and myelin

1995 • 29 citations

Protein growth factors as potential therapies for central nervous system demyelinative disorders

1994 • 25 citations